Projects per year
Personal profile
Research interests
Innate and adaptive immune responses in vector-borne diseases and Lyme borreliosis in particular.
Ticks require a bloodmeal to reproduce, during which they not only transmit Borrelia burgdorferi - the causative agent of Lyme borreliosis -, but also introduce physiologically active proteins into the host skin. These proteins inhibit blood coagulation and suppress local host immune responses, which facilitates both tick feeding as well as B. burgdorferi infection. Identification of the molecular mechanisms involved in immunosuppression induced by tick salivary proteins contributes to the understanding of the pathogenesis of Lyme borreliosis and could lead to the development of novel anti-inflammatory or immunosuppressive agents. In addition, interfering with tick-host-pathogen interactions, for example by an anti-tick vaccin based on specific tick (salivary) proteins, could prevent transmission of B. burgdorferi from the tick to the host.
specialisation
Internal Medicine - Infectious Diseases
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Tick-host-pathogen interactions in Lyme borreliosis, Amsterdam institute for Infection and Immunity (AMC)
Award Date: 13 Mar 2009
External positions
Member of the board of the Dutch Lyme borreliosis center
31 Oct 2001 → …
Program leader Infectious Diseases of the Amsterdam Infection & Immunity Institute
31 Jan 2001 → …
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 2 Active
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Hovius J.W.R.: Ticks and Tick-borne Diseases
Hovius, J., Ersoz, J., Klouwens, M., Koetsveld, J., Mason, L., Trentelman, J., Ursinus, J., Wagemakers, A. & Jahfari, S.
1/01/2013 → …
Project: Research
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van der Poll T.: Innate immunity and coagulation in infection
Anas, A., Brands, X., Claushuis, D., Cranendonk, D., Ding, C., Harris, V., Klouwens, M., Koetsveld, J., Lankelma, J., Maag, A., Mason, L., van der Meer, A. J., Meijer, M., Otto, N., Perlee, D., de Porto, A., Qin, W., Ramirez Moral, R. M., Trentelman, J., Ursinus, J., Waasdorp, M., Wagemakers, A., Wiewel, M., Yang, J., van der Poll, T., Hovius, J., van t Veer, K., de Vos, A., Wiersinga, W., van Heijst, J., Scicluna, B., de Beer, R. & Kruijswijk, D.
1/01/2007 → …
Project: Research
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A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
Schuijt, T. J., Coumou, J., Narasimhan, S., Dai, J., Deponte, K., Wouters, D., Brouwer, M., Oei, A., Roelofs, J. J. T. H., van Dam, A. P., van der Poll, T., van't Veer, C., Hovius, J. W. & Fikrig, E., 2011, In: CELL Host & Microbe. 10, 2, p. 136-146Research output: Contribution to journal › Article › Academic › peer-review
127 Citations (Scopus) -
A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe
Hovius, J. W. R., de Wever, B., Sohne, M., Brouwer, M. C., Coumou, J., Wagemakers, A., Oei, A., Knol, H., Narasimhan, S., Hodiamont, C. J., Jahfari, S., Pals, S. T., Horlings, H. M., Fikrig, E., Sprong, H. & van Oers, M. H. J., 2013, In: Lancet. 382, 9892, p. 658Research output: Contribution to journal › Editorial › Academic › peer-review
207 Citations (Scopus) -
Ticking the right boxes: Classification of patients suspected of Lyme borreliosis at an academic referral center in the Netherlands
Coumou, J., Herkes, E. A., Brouwer, M. C., van de Beek, D., Tas, S. W., Casteelen, G., van Vugt, M., Starink, M. V., de Vries, H. J. C., de Wever, B., Spanjaard, L. & Hovius, J. W. R., 1 Apr 2015, In: Clinical Microbiology and Infection. 21, 4, p. 368.e11-368.e20Research output: Contribution to journal › Article › Academic › peer-review
Open Access39 Citations (Scopus) -
Probability of Spirochete Borrelia miyamotoi Transmission from Ticks to Humans
Sarksyan, D. S., Platonov, A. E., Karan, L. S., Shipulin, G. A., Sprong, H. & Hovius, J. W. R., 2015, In: Emerging infectious diseases. 21, 12, p. 2273-2274Research output: Contribution to journal › Comment/Letter to the editor › Academic
17 Citations (Scopus)