Karel van Dort

Research output

Research output per year 2004 2015 2017 2022 2023 2023

• 42 Article
• 3 Comment/Letter to the editor
• 1 Meeting Abstract

Research output per year

Research output per year

Search results

• 2023

  25-Hydroxyvitamin D concentrations do not affect the humoral or cellular immune response following SARS-CoV-2 mRNA vaccinations

  Amsterdam UMC COVID-19 S3/HCW study group, 2023, (E-pub ahead of print) In: Vaccine.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation

  van Pul, L., Maurer, I., Boeser-Nunnink, B. D. M., Harskamp, A. M., van Dort, K. A. & Kootstra, N. A., 1 Nov 2023, In: AIDS (London, England). 37, 13, p. 1959-1969 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Immunogenicity of bivalent omicron (BA.1) booster vaccination after different priming regimens in health-care workers in the Netherlands (SWITCH ON): results from the direct boost group of an open-label, multicentre, randomised controlled trial

  SWITCH ON Research Group, Aug 2023, In: The Lancet Infectious Diseases. 23, 8, p. 901-913 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Robust Vaccine-Induced as Well as Hybrid B- and T-Cell Immunity across SARS-CoV-2 Vaccine Platforms in People with HIV

  AGEhIV Cohort Study, 1 May 2023, In: Microbiology spectrum. 11, 3, p. e0115523 20 p., e0115523.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Virological and immunological correlates of HIV posttreatment control after temporal antiretroviral therapy during acute HIV infection

  van Paassen, P. M., van Pul, L., van der Straten, K., Buchholtz, N. V. J. E., Grobben, M., van Nuenen, A. C., van Dort, K. A., Boeser-Nunnink, B. D., van den Essenburg, M. D., Burger, J. A., van Luin, M., Jurriaans, S., Sanders, R. W., Swelsen, W. T., Symons, J., Klouwens, M. J., Nijhuis, M., van Gils, M. J., Prins, J. M., de Bree, G. J., & 1 othersKootstra, N. A., 1 Dec 2023, In: AIDS (London, England). 37, 15, p. 2297-2304 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern

  RECoVERED Study Group, 18 Jan 2022, In: Cell Reports Medicine. 3, 1, 100486.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  13 Citations (Scopus)

• Identification of a Novel HBV Encoded miRNA Using Next Generation Sequencing

  Loukachov, V., van Dort, K. A., Jansen, L., Reesink, H. W. & Kootstra, N. A., 1 Jun 2022, In: Viruses. 14, 6, 1223.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Identification of Liver and Plasma microRNAs in Chronic Hepatitis B Virus infection

  Loukachov, V. V., van Dort, K. A., Maurer, I., Takkenberg, R. B., de Niet, A., Reesink, H. W., Willemse, S. B. & Kootstra, N. A., 2 Jun 2022, In: Frontiers in cellular and infection microbiology. 12, 790964.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• Quantified integrated hepatitis B virus is related to viral activity in patients with chronic hepatitis B

  Erken, R., Loukachov, V., van Dort, K., van den Hurk, A., Takkenberg, R. B., de Niet, A., Jansen, L., Willemse, S., Reesink, H. & Kootstra, N., Jul 2022, In: Hepatology. 76, 1, p. 196-206 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  16 Citations (Scopus)
• 2021

  CD9 and ITGA3 are regulated during HIV-1 infection in macrophages to support viral replication

  Kruize, Z., Cobos Jiménez, V., Martinez, F. O., di Vincenzo, R., van Dort, K. A., van Nuenen, A. C., Booiman, T. & Kootstra, N. A., 1 Oct 2021, In: Virology. 562, p. 9-18 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction

  Kruize, Z., van Nuenen, A. C., van Wijk, S. W., Girigorie, A. F., van Dort, K. A., Booiman, T. & Kootstra, N. A., 6 Mar 2021, In: Viruses. 13, 3, 423.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)
• 2020

  Human immunodeficiency virus-negative men who have sex with men have an altered T-Cell phenotype and bioenergy metabolism

  Kruize, Z., Maurer, I., van Dort, K. A., van den Elshout, M. A. M., Hoornenborg, E., Booiman, T., Prins, M. & Kootstra, N. A., 1 Aug 2020, In: Open forum infectious diseases. 7, 8, ofaa284.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• MAVS genetic variation is associated with decreased HIV-1 replication in vitro and reduced cd4+ t cell infection in HIV-1-infected individuals

  Stunnenberg, M., van Pul, L., Sprokholt, J. K., van Dort, K. A., Gringhuis, S. I., Geijtenbeek, T. B. H. & Kootstra, N. A., 1 Jul 2020, In: Viruses. 12, 7, 764.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)
• 2017

  Dynamics of the Immune Response in Acute Hepatitis B Infection

  Stelma, F., Willemse, S. B., Erken, R., de Niet, A., Sinnige, M. J., van Dort, K., Zaaijer, H. L., van Leeuwen, E. M. M., Kootstra, N. A. & Reesink, H. W., 2017, In: Open forum infectious diseases. 4, 4, p. UNSP ofx231

  Research output: Contribution to journal › Article › Academic › peer-review

• HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

  Gringhuis, S. I., Hertoghs, N., Kaptein, T. M., Zijlstra-Willems, E. M., Sarrami-Fooroshani, R., Sprokholt, J. K., van Teijlingen, N. H., Kootstra, N. A., Booiman, T., van Dort, K. A., Ribeiro, C. M. S., Drewniak, A. & Geijtenbeek, T. B. H., 2017, In: Nature immunology. 18, 2, p. 225-235

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  90 Citations (Scopus)

• Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity

  Stelma, F., de Niet, A., Sinnige, M. J., van Dort, K. A., van Gisbergen, K. P. J. M., Verheij, J., van Leeuwen, E. M. M., Kootstra, N. A. & Reesink, H. W., 2017, In: Scientific reports. 7, 1, p. 6172

  Research output: Contribution to journal › Article › Academic › peer-review
  75 Citations (Scopus)

• Plasma MicroRNA Levels Are Associated With Hepatitis B e Antigen Status and Treatment Response in Chronic Hepatitis B Patients

  van der Ree, M. H., Jansen, L., Kruize, Z., van Nuenen, A. C., van Dort, K. A., Takkenberg, R. B., Reesink, H. W. & Kootstra, N. A., 1 May 2017, In: Journal of infectious diseases. 215, 9, p. 1421-1429 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  41 Citations (Scopus)

• Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients

  Jansen, L., Welkers, M. R. A., van Dort, K. A., Takkenberg, R. B., Lopatin, U., Zaaijer, H. L., de Jong, M. D., Reesink, H. W. & Kootstra, N. A., 2017, In: Antiviral Research. 145, p. 87-95

  Research output: Contribution to journal › Article › Academic › peer-review
  12 Citations (Scopus)
• 2016

  Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues

  Jansen, L., Kootstra, N. A., van Dort, K. A., Takkenberg, R. B., Reesink, H. W. & Zaaijer, H. L., 2016, In: Journal of infectious diseases. 213, 2, p. 224-232

  Research output: Contribution to journal › Article › Academic › peer-review
  122 Citations (Scopus)

• Mutations in CypA Binding Region of HIV-1 Capsid Affect Capsid Stability and Viral Replication in Primary Macrophages

  Setiawan, L. C., van Dort, K. A., Rits, M. A. N. & Kootstra, N. A., 2016, In: AIDS Research and Human Retroviruses. 32, 4, p. 390-398

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)
• 2015

  ADAR1 Facilitates HIV-1 Replication in Primary CD4(+) T Cells

  Cuadrado, E., Booiman, T., van Hamme, J. L., Jansen, M. H., van Dort, K. A., Vanderver, A., Rice, G. I., Crow, Y. J., Kootstra, N. A. & Kuijpers, T. W., 2015, In: PLOS ONE. 10, 12, p. e0143613

  Research output: Contribution to journal › Article › Academic › peer-review
  16 Citations (Scopus)

• An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B

  Jansen, L., de Niet, A., Makowska, Z., Dill, M. T., van Dort, K. A., Terpstra, V., Bart Takkenberg, R., Janssen, H. L. A., Heim, M. H., Kootstra, N. A. & Reesink, H. W., 2015, In: Liver international. 35, 7, p. 1824-1832

  Research output: Contribution to journal › Article › Academic › peer-review
  19 Citations (Scopus)

• DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner

  Booiman, T., Loukachov, V. V., van Dort, K. A., van 't Wout, A. B. & Kootstra, N. A., 2015, In: PLOS ONE. 10, 12, p. e0144229

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA

  Cobos Jiménez, V., Martinez, F. O., Booiman, T., van Dort, K. A., van de Klundert, M. A. A., Gordon, S., Geijtenbeek, T. B. H. & Kootstra, N. A., 2015, In: Virology. 486, p. 94-104

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)
• 2014

  HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels

  Jansen, L., de Niet, A., Stelma, F., van Iperen, E. P. A., van Dort, K. A., Tempelmans Plat-Sinnige, M. J., Takkenberg, R. B., Chin, D. J., Zwinderman, A. H. K., Lopatin, U., Kootstra, N. A. & Reesink, H. W., 2014, In: Journal of Hepatology. 61, 4, p. 730-737

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription

  Booiman, T., Cobos Jiménez, V., van Dort, K. A., van 't Wout, A. B. & Kootstra, N. A., 2014, In: PLOS ONE. 9, 10, p. e109673

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)
• 2013

  Identification of a new genotype of Torque Teno Mini virus

  Jazaeri Farsani, S. M., Jebbink, M. F., Deijs, M., Canuti, M., van Dort, K. A., Bakker, M., Grady, B. P. X., Prins, M., van Hemert, F. J., Kootstra, N. A. & van der Hoek, L., 2013, In: Virology journal. 10, 1, p. 323

  Research output: Contribution to journal › Article › Academic › peer-review
  17 Citations (Scopus)
• 2012

  Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons

  Cobos Jiménez, V., Booiman, T., de Taeye, S. W., van Dort, K. A., Rits, M. A. N., Hamann, J. & Kootstra, N. A., 2012, In: Scientific reports. 2, p. 763

  Research output: Contribution to journal › Article › Academic › peer-review
  78 Citations (Scopus)

• Regulation of CXCR4 conformation by the small GTPase Rac1: Implications for HIV infection

  Zoughlami, Y., Voermans, C., Brussen, K., Van Dort, K. A., Kootstra, N. A., Maussang, D., Smit, M. J., Hordijk, P. L., Van Hennik, P. B., Maussang-Detaille, D. M. & Hordijk, PL., 1 Mar 2012, In: Blood. 119, 9, p. 2024-2032 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  19 Citations (Scopus)
• 2011

  Comparison of in vivo and in vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants

  Edo-Matas, D., van Dort, K. A., Setiawan, L. C., Schuitemaker, H. & Kootstra, N. A., 2011, In: Virology. 412, 2, p. 269-277

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages

  Bol, S. M., Booiman, T., Bunnik, E. M., Moerland, P. D., van Dort, K., Strauss, J. F., Sieberer, M., Schuitemaker, H., Kootstra, N. A. & van 't Wout, A. B., 2011, In: Virology. 420, 1, p. 32-42

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)
• 2008

  Polymorphisms in the Regulatory Region of the Cyclophilin A Gene Influence the Susceptibility for HIV-1 Infection

  Rits, M. A. N., van Dort, K. A. & Kootstra, N. A., 2008, In: PLOS ONE. 3, 12, p. e3975

  Research output: Contribution to journal › Article › Academic › peer-review
  27 Citations (Scopus)

• The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection

  van Manen, D., Rits, M. A. N., Beugeling, C., van Dort, K., Schuitemaker, H. & Kootstra, N. A., 2008, In: PLoS pathogens. 4, 2, p. e18

  Research output: Contribution to journal › Article › Academic › peer-review
  108 Citations (Scopus)

• Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection

  Piriou, E., van Dort, K., Otto, S., van Oers, M. H. J. & van Baarle, D., 2008, In: Clinical Infectious Diseases. 46, 2, p. 313-316

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)
• 2007

  Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein

  Rits, M. A. N., van Dort, K. A., Münk, C., Meijer, A. B. & Kootstra, N. A., 2007, In: Molecular therapy. 15, 5, p. 930-937

  Research output: Contribution to journal › Article › Academic › peer-review
  17 Citations (Scopus)

• The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase

  Kootstra, N. A., Navis, M., Beugeling, C., van Dort, K. A. & Schuitemaker, H., 2007, In: AIDS (London, England). 21, 15, p. 2015-2023

  Research output: Contribution to journal › Article › Academic › peer-review
  28 Citations (Scopus)
• 2006

  Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient

  Piriou, E. R. W. A. N., van Dort, K., Weel, J. F. L., Bemelman, F. J., Gamadia, L. E., van Oers, M. H. J. & van Baarle, D., 2006, In: Clinical immunology (Orlando, Fla.). 119, 1, p. 16-20

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)

• Long-term highly active antiretroviral therapy in chronic HIV-1 infection: evidence for reconstitution of antiviral immunity

  Jansen, C. A., Piriou, E., de Cuyper, I. M., van Dort, K., Lange, J. M. A., Miedema, F. & van Baarle, D., 2006, In: Antiviral therapy. 11, 1, p. 105-116

  Research output: Contribution to journal › Article › Academic › peer-review

  22 Citations (Scopus)
• 2005

  Loss of EBNA1-specific memory CD4(+) and CD8(+) T cells in HIV-infected patients progressing to AIDS-related non-hodgkin lymphoma

  Piriou, E., van Dort, K., Nanlohy, N. M., van Oers, M. H. J., Miedema, F. & van Baarle, D., 2005, In: Blood. 106, 9, p. 3166-3174

  Research output: Contribution to journal › Article › Academic › peer-review
  81 Citations (Scopus)

• Novel method for detection of virus-specific CD41+ T cells indicates a decreased EBV-specific CD4+ T cell response in untreated HIV-infected subjects

  Piriou, E. R., van Dort, K., Nanlohy, N. M., van Oers, M. H., Miedema, F. & van Baarle, D., 2005, In: European journal of immunology. 35, 3, p. 796-805

  Research output: Contribution to journal › Article › Academic › peer-review
  22 Citations (Scopus)

• Reconstitution of EBV latent but not lytic antigen-specific CD4(+) and CD8(+) T cells after HIV treatment with highly active antiretroviral therapy

  Piriou, E., Jansen, C. A., van Dort, K., de Cuyper, I., Nanlohy, N. M., Lange, J. M. A., van Oers, M. H. J., Miedema, F. & van Baarle, D., 2005, In: Journal of immunology (Baltimore, Md.. 175, 3, p. 2010-2017

  Research output: Contribution to journal › Article › Academic › peer-review
  29 Citations (Scopus)
• 2004

  Altered EBV viral load setpoint after HIV seroconversion is in accordance with lack of predictive value of EBV load for the occurrence of AIDS-related non-Hodgkin lymphoma

  Piriou, E. R., van Dort, K., Nanlohy, N. M., Miedema, F., van Oers, M. H. & van Baarle, D., 2004, In: Journal of immunology (Baltimore, Md.. 172, 11, p. 6931-6937

  Research output: Contribution to journal › Article › Academic › peer-review
  53 Citations (Scopus)