Inflammation and coagulation are intertwined processes involved in several pathologies such as septic shock. TLR mediated inflammation and TF initiated blood coagulation, and negative regulation of these pathways, have been and are separate foci of the research of van 't Veer. These have condensed to a line of research that studies the role and regulation of blood coagulation during bacterial infections. The research comprises infection models in mice, in vivo sterile inflammation in humans and in vitro studies in whole blood or cells of the immune system of humans and mice. Furthermore structure function research on the TLR regulator IRAK-M and a coagulation inhibitor derived from ticks named TIX-5 (specific inhibitor of the factor Xa activation of coagulation factor V) is performed to get more insight in the processes of respectively immunosuppression and thrombosis/bleeding.