Kristiaan Lenos

Research output

Research output per year 2013 2021 2023 2023

• 19 Article

Research output per year

Research output per year

Search results

• 2023

  Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development

  Ouahoud, S., Westendorp, B. F., Voorneveld, P. W., Abudukelimu, S., Koelink, P. J., Pascual Garcia, E., Buuren, J. F. I., Harryvan, T. J., Lenos, K. J., van Wezel, T., Offerhaus, J. A., Fariña-Sarasqueta, A., Crobach, S., Slingerland, M., Hardwick, J. C. H. & Hawinkels, L. J. A. C., Jan 2023, In: Journal of Gastroenterology. 58, 1, p. 25-43 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer

  Küçükköse, E., Laoukili, J., Gorelick, A. N., Degner, S., Laclé, M. M., van den Bent, L., Peters, N. A., Verheem, A., Hung, W-T., Frenkel, N. C., Wassenaar, E. C. E., Lansu, N., Lenos, K. J., Vermeulen, L., Koopman, M., Roodhart, J. M. L., Kops, G. J. P. L., Borel Rinkes, I. H. M., Hagendoorn, J., Naxerova, K., & 1 othersKranenburg, O., Aug 2023, In: Gastroenterology. 165, 2, p. 429-444.e15

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Real-time analysis of the cancer genome and fragmentome from plasma and urine cell-free DNA using nanopore sequencing

  van der Pol, Y., Tantyo, N. A., Evander, N., Hentschel, A. E., Wever, B. M. M., Ramaker, J., Bootsma, S., Fransen, M. F., Lenos, K. J., Vermeulen, L., Schneiders, F. L., Bahce, I., Nieuwenhuijzen, J. A., Steenbergen, R. D. M., Pegtel, D. M., Moldovan, N. & Mouliere, F., 7 Dec 2023, In: EMBO molecular medicine. 15, 12, e17282.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer

  Buikhuisen, J. Y., Gomez Barila, P. M., Cameron, K., Suijkerbuijk, S. J. E., Lieftink, C., di Franco, S., Krotenberg Garcia, A., Uceda Castro, R., Lenos, K. J., Nijman, L. E., Torang, A., Longobardi, C., de Jong, J. H., Dekker, D., Stassi, G., Vermeulen, L., Beijersbergen, R. L., van Rheenen, J., Huveneers, S. & Medema, J. P., 1 Dec 2023, In: Journal of experimental & clinical cancer research. 42, 1, 56.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Using picoliter droplet deposition to track clonal competition in adherent and organoid cancer cell cultures

  Baglamis, S., Sheraton, V. M., Meijer, D., Qian, H., Hoebe, R. A., Lenos, K. J., Betjes, M. A., Betjes, M. A., Tans, S., van Zon, J., Vermeulen, L. & Krawczyk, P. M., 1 Dec 2023, In: Scientific reports. 13, 1, p. 18832 18832.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  Behavioral factors to modulate immunotherapy efficacy in cancer

  Jongerius, C., Vermeulen, L., van Egmond, M., Evers, A. W. M., Buffart, L. M. & Lenos, K. J., 16 Dec 2022, In: Frontiers in immunology. 13, p. 1066359 1066359.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Molecular characterization of colorectal cancer related peritoneal metastatic disease

  Lenos, K. J., Bach, S., Ferreira Moreno, L., ten Hoorn, S., Sluiter, N. R., Bootsma, S., Vieira Braga, F. A., Nijman, L. E., van den Bosch, T., Miedema, D. M., van Dijk, E., Ylstra, B., Kulicke, R., Davis, F. P., Stransky, N., Smolen, G. A., Coebergh van den Braak, R. R. J., IJzermans, J. N. M., Martens, J. W. M., Hallam, S., & 20 othersBeggs, A. D., Kops, G. J. P. L., Lansu, N., Bastiaenen, V. P., Klaver, C. E. L., Lecca, M. C., el Makrini, K., Elbers, C. C., Dings, M. P. G., van Noesel, C. J. M., Kranenburg, O., Medema, J. P., Koster, J., Koens, L., Punt, C. J. A., Tanis, P. J., de Hingh, I. H., Bijlsma, M. F., Tuynman, J. B. & Vermeulen, L., 1 Dec 2022, In: Nature communications. 13, 1, 4443.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  24 Citations (Scopus)
• 2021

  Chromosomal copy number heterogeneity predicts survival rates across cancers

  van Dijk, E., van den Bosch, T., Lenos, K. J., el Makrini, K., Nijman, L. E., van Essen, H. F. B., Lansu, N., Boekhout, M., Hageman, J. H., Fitzgerald, R. C., Punt, C. J. A., Tuynman, J. B., Snippert, H. J. G., Kops, G. J. P. L., Medema, J. P., Ylstra, B., Vermeulen, L. & Miedema, D. M., 1 Dec 2021, In: Nature communications. 12, 1, 3188.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  31 Citations (Scopus)

• Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas

  Lodestijn, S. C., van den Bosch, T., Nijman, L. E., Moreno, L. F., Schlingemann, S., Sheraton, V. M., van Neerven, S. M., Koning, J. J., Vieira Braga, F. A., Paauw, N. J., Lecca, M. C., Lenos, K. J., Morrissey, E., Miedema, D. M., Winton, D. J., Bijlsma, M. F., Vermeulen, L. & Morissey, E., 4 Nov 2021, In: Cell Stem Cell. 28, 11, p. 2009-2019.e4 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer

  Lodestijn, S. C., Miedema, D. M., Lenos, K. J., Nijman, L. E., Belt, S. C., El Makrini, K., Lecca, M. C., Waasdorp, C., van den Bosch, T., Bijlsma, M. F. & Vermeulen, L., 19 Oct 2021, In: Cell reports. 37, 3, p. 109852 109852.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  9 Citations (Scopus)
• 2020

  A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

  Narayan, R. S., Molenaar, P., Teng, J., Cornelissen, F. M. G., Roelofs, I., Menezes, R., Dik, R., Lagerweij, T., Broersma, Y., Petersen, N., Marin Soto, J. A., Brands, E., van Kuiken, P., Lecca, M. C., Lenos, K. J., in ‘t Veld, S. G. J. G., van Wieringen, W., Lang, F. F., Sulman, E., Verhaak, R., & 13 othersBaumert, B. G., Stalpers, L. J. A., Vermeulen, L., Watts, C., Bailey, D., Slotman, B. J., Versteeg, R., Noske, D., Sminia, P., Tannous, B. A., Wurdinger, T., Koster, J. & Westerman, B. A., 1 Dec 2020, In: Nature communications. 11, 1, 2935.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  48 Citations (Scopus)

• A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity

  Bastiaenen, V. P., Klaver, C. E. L., van der Heijden, M. C. S., Nijman, L. E., Lecca, M. C., Tanis, P. J., Lenos, K. J. & Vermeulen, L., 1 Nov 2020, In: Laboratory investigation; a journal of technical methods and pathology. 100, 11, p. 1465-1474 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  13 Citations (Scopus)
• 2019

  A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue

  Lenos, K. J., Lodestijn, S. C., Lyons, S. K., Bijlsma, M. F., Miedema, D. M. & Vermeulen, L., Sept 2019, In: Nature protocols. 14, 9, p. 2648-2671

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)

• Cancer stem cells: here, there, and everywhere

  Lodestijn, S. C., Lenos, K. J., Miedema, D. M., Bijlsma, M. F. & Vermeulen, L., 2019, In: Molecular & cellular oncology. 6, 1, p. e1540235.1-e1540235.3

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2018

  Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3

  Sahasrabudhe, N. M., Lenos, K., van der Horst, J. C., Rodríguez, E. & van Vliet, S. J., 2018, In: Biological chemistry. 399, 7, p. 649-659 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  14 Citations (Scopus)

• Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

  Lenos, K. J., Miedema, D. M., Lodestijn, S. C., Nijman, L. E., van den Bosch, T., Romero Ros, X., Lourenço, F. C., Lecca, M. C., van der Heijden, M., van Neerven, S. M., van Oort, A., Leveille, N., Adam, R. S., de Sousa e Melo, F., Otten, J., Veerman, P., Hypolite, G., Koens, L., Lyons, S. K., Stassi, G., & 5 othersWinton, D. J., Medema, J. P., Morrissey, E., Bijlsma, M. F. & Vermeulen, L., 2018, In: Nature cell biology. 20, 10, p. 1193-1202

  Research output: Contribution to journal › Article › Academic › peer-review
  122 Citations (Scopus)
• 2016

  Cancer stem cells don't waste their time cleaning-low proteasome activity, a marker for cancer stem cell function

  Lenos, K. J. & Vermeulen, L., 2016, In: Annals of Translational Medicine. 4, 24, p. 519

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)
• 2015

  MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients

  Lenos, K., Goos, J. A. C. M., Vuist, I. M., den Uil, S. H., Delis-van Diemen, P. M., Belt, E. J. T., Stockmann, H. B. A. C., Bril, H., de Wit, M., Carvalho, B., Giblett, S., Pritchard, C. A., Meijer, G. A., van Kooyk, Y., Fijneman, R. J. A. & van Vliet, S. J., 2015, In: Oncotarget. 6, 28, p. 26278-26290

  Research output: Contribution to journal › Article › Academic › peer-review
  35 Citations (Scopus)
• 2013

  Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL)

  Van Vliet, S. J., Vuist, I. M., Lenos, K., Tefsen, B., Kalay, H., García-Vallejo, J. J. & Van Kooyk, Y., 20 Sept 2013, In: Journal of Biological Chemistry. 288, 38, p. 27519-27532 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  27 Citations (Scopus)