Research output per year
Research output per year
Personal profile
Research interests
Designing hepatitis C virus (HCV) E1E2 glycoproteins for structural studies and vaccine studies.
Producing and designing novel HIV-1 envelope glycoproteins.
specialisation
hepatitis C virus (HCV), HIV-1, envelope glycoproteins, vaccines, nanoparticles
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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A panel of hepatitis C virus glycoproteins for the characterization of antibody responses using antibodies with diverse recognition and neutralization patterns
Chumbe, A., Grobben, M., Capella-Pujol, J., Koekkoek, S. M., Zon, I., Slamanig, S., Merat, S. J., Beaumont, T., Sliepen, K., Schinkel, J. & van Gils, M. J., 1 Mar 2024, In: Virus Research. 341, 199308.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice
Brinkkemper, M., Poniman, M., Siteur-van Rijnstra, E., Iddouch, W. A., Bijl, T. P. L., Guerra, D., Tejjani, K., Grobben, M., Bhoelan, F., Bemelman, D., Kempers, R., van Gils, M. J., Sliepen, K., Stegmann, T., van der Velden, Y. U. & Sanders, R. W., 17 May 2024, In: iScience. 27, 5, 109719.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
del Moral-Sánchez, I., Wee, E. G., Xian, Y., Lee, W-H., Allen, J. D., Torrents de la Peña, A., Fróes Rocha, R., Ferguson, J., León, A. N., Koekkoek, S., Schermer, E. E., Burger, J. A., Kumar, S., Zwolsman, R., Brinkkemper, M., Aartse, A., Eggink, D., Han, J., Yuan, M., Crispin, M., & 6 others, 1 Dec 2024, In: npj Vaccines. 9, 1, 74.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses
Radić, L., Sliepen, K., Yin, V., Brinkkemper, M., Capella-Pujol, J., Schriek, A. I., Torres, J. L., Bangaru, S., Burger, J. A., Poniman, M., Bontjer, I., Bouhuijs, J. H., Gideonse, D., Eggink, D., Ward, A. B., Heck, A. J. R., van Gils, M. J., Sanders, R. W. & Schinkel, J., 21 Apr 2023, In: iScience. 26, 4, 106540.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Broad SARS-CoV-2 neutralization by monoclonal and bispecific antibodies derived from a Gamma-infected individual
Guerra, D., Beaumont, T., Radić, L., Kerster, G., van der Straten, K., Yuan, M., Torres, J. L., Lee, W-H., Liu, H., Poniman, M., Bontjer, I., Burger, J. A., Claireaux, M., Caniels, T. G., Snitselaar, J. L., Bijl, T. P. L., Kruijer, S., Ozorowski, G., Gideonse, D., Sliepen, K., & 6 others, 20 Oct 2023, In: iScience. 26, 10, 108009.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus)
Datasets
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Crystal Structure of HIV-1 Env ConM SOSIP.v7 in Complex with bNAb PGT124 and 35O22
Sliepen, K. (Contributor), Han, B. W. (Contributor), Bontjer, I. (Contributor), Mooij, P. (Contributor), Garces, F. (Contributor), Behrens, A. (Contributor), Rantalainen, K. (Contributor), Kumar, S. (Contributor), Sarkar, A. (Contributor), Brouwer, P. J. M. (Contributor), Hua, Y. (Contributor), Tolazzi, M. (Contributor), Schermer, E. (Contributor), Torres, J. L. (Contributor), Ozorowski, G. (Contributor), van der Woude, P. (Contributor), de la Peña, A. T. (Contributor), van Breemen, M. (Contributor), Camacho-Sánchez, J. M. (Contributor), Burger, J. (Contributor), Medina Ramirez, M. (Contributor), González, N. (Contributor), Alcami, J. (Contributor), LaBranche, C. (Contributor), Scarlatti, G. (Contributor), van Gils, M. (Contributor), Crispin, M. (Contributor), Montefiori, D. C. (Contributor), Ward, A. B. (Contributor), Koopman, G. (Contributor), Moore, J. P. (Contributor), Shattock, R. J. (Contributor), Bogers, W. M. (Contributor), Wilson, I. A. (Contributor) & Sanders, R. (Contributor), Protein Data Bank (PDB), 22 May 2019
DOI: 10.2210/pdb6IEQ, https://www.wwpdb.org/pdb?id=pdb_00006ieq
Dataset
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BG505 SOSIP-I53-50NP
Brouwer, P. J. M. (Contributor), Antanasijevic, A. (Contributor), Berndsen, Z. (Contributor), Yasmeen, A. (Contributor), Fiala, B. (Contributor), Bijl, T. P. L. (Contributor), Bontjer, I. (Contributor), Bale, J. B. (Contributor), Sheffler, W. (Contributor), Allen, J. D. (Contributor), Schorcht, A. (Contributor), Burger, J. (Contributor), Camacho, M. (Contributor), Ellis, D. (Contributor), Cottrell, C. A. (Contributor), Behrens, A. (Contributor), Catalano, M. (Contributor), Del Moral Sanchez, I. (Contributor), Ketas, T. J. (Contributor), LaBranche, C. (Contributor), van Gils, M. (Contributor), Sliepen, K. (Contributor), Stewart, L. J. (Contributor), Crispin, M. (Contributor), Montefiori, D. C. (Contributor), Baker, D. (Contributor), Moore, J. P. (Contributor), Klasse, P. J. (Contributor), Ward, A. B. (Contributor), King, N. P. (Contributor) & Sanders, R. (Contributor), Protein Data Bank (PDB), 19 Jun 2019
DOI: 10.2210/pdb6P6F, https://www.wwpdb.org/pdb?id=pdb_00006p6f
Dataset
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Cryo-EM structure of ConSOSL.UFO.664 (ConS) in complex with bNAb PGT122
Martin, G. M. (Contributor), Russell, R. A. (Contributor), Mundsperger, P. (Contributor), Harris, S. (Contributor), Jovanoska, L. (Contributor), Trajano, L. F. (Contributor), Schiffner, T. (Contributor), Fabian, K. (Contributor), Tolazzi, M. (Contributor), Scarlatti, G. (Contributor), McFarlane, L. (Contributor), Cheeseman, H. (Contributor), Aldon, Y. (Contributor), Schermer, E. E. (Contributor), Breemen, M. (Contributor), Sliepen, K. (Contributor), Katinger, D. (Contributor), Kunert, R. (Contributor), Sanders, R. (Contributor), Shattock, R. (Contributor), Ward, A. B. (Contributor) & Sattentau, Q. J. (Contributor), Protein Data Bank (PDB), 9 Mar 2022
DOI: 10.2210/pdb7LX2, https://www.wwpdb.org/pdb?id=pdb_00007lx2
Dataset
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Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195
Kong, L. (Contributor), Torrents De La Peña, A. (Contributor), Deller, M. C. (Contributor), Garces, F. (Contributor), Sliepen, K. (Contributor), Hua, Y. (Contributor), Stanfield, R. L. (Contributor), Sanders, R. (Contributor) & Wilson, I. A. (Contributor), Protein Data Bank (PDB), 7 Oct 2015
DOI: 10.2210/pdb5C7K, https://www.wwpdb.org/pdb?id=pdb_00005c7k
Dataset
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HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv
Torrents de la Peña, A. (Contributor), Julien, J. (Contributor), de Taeye, S. (Contributor), Garces, F. (Contributor), Guttman, M. (Contributor), Ozorowski, G. (Contributor), Pritchard, L. K. (Contributor), Behrens, A. (Contributor), Go, E. P. (Contributor), Burger, J. (Contributor), Schermer, E. E. (Contributor), Sliepen, K. (Contributor), Ketas, T. J. (Contributor), Pugach, P. (Contributor), Yasmeen, A. (Contributor), Cottrell, C. A. (Contributor), Torres, J. L. (Contributor), Vavourakis, C. D. (Contributor), van Gils, M. (Contributor), LaBranche, C. (Contributor), Montefiori, D. C. (Contributor), Desaire, H. (Contributor), Crispin, M. (Contributor), Klasse, P. J. (Contributor), Lee, K. K. (Contributor), Moore, J. P. (Contributor), Ward, A. B. (Contributor), Wilson, I. A. (Contributor) & Sanders, R. (Contributor), Protein Data Bank (PDB), 4 Apr 2018
DOI: 10.2210/pdb5WDU, https://www.wwpdb.org/pdb?id=pdb_00005wdu
Dataset