Laura Hagens

Research output

Research output per year 2020 2021 2022 2023 2024

• 25 Article
• 2 Review article
• 1 Comment/Letter to the editor
• 1 Phd-Thesis - Research and graduation internal

Research output per year

Research output per year

Search results

• 2024

  Breath metabolomics for diagnosis of acute respiratory distress syndrome

  Zhang, S., Hagens, L. A., Heijnen, N. F. L., Smit, M. R., Brinkman, P., Fenn, D., van der Poll, T., Schultz, M. J., Bergmans, D. C. J. J., Schnabel, R. M. & Bos, L. D. J., 1 Dec 2024, In: Critical Care. 28, 1, 96.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• HS-GC–MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study

  Lilien, T. A., Fenn, D. W., Brinkman, P., Hagens, L. A., Smit, M. R., Heijnen, N. F. L., van Woensel, J. B. M., Bos, L. D. J., Bem, R. A. & on behalf of the DARTS study group, 1 Dec 2024, In: Intensive Care Medicine Experimental. 12, 1, 14.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2023

  Biomarkers of alveolar epithelial injury and endothelial dysfunction are associated with scores of pulmonary edema in invasively ventilated patients

  DARTS consortium, 1 Jan 2023, In: American journal of physiology. Lung cellular and molecular physiology. 324, 1, p. L38-L47

  Research output: Contribution to journal › Article › Academic › peer-review
  5 Citations (Scopus)

• Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19

  Ibelings, R., van den Brom, C. E. & the Amsterdam UMC COVID-19 biobank study group, 1 Sept 2023, In: Artery Research. 29, 3, p. 83-93 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Lung Ultrasound Prediction Model for Acute Respiratory Distress Syndrome: A Multicenter Prospective Observational Study

  DARTS Consortium members, 15 Jun 2023, In: American journal of respiratory and critical care medicine. 207, 12, p. 1591-1601 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  19 Citations (Scopus)

• Octane in exhaled breath to diagnose acute respiratory distress syndrome in invasively ventilated intensive care unit patients

  Hagens, L. A., Heijnen, N. F. L., Smit, M. R., Verschueren, A. R. M., Nijsen, T. M. E., Geven, I., Presură, C. N., Rietman, R., Fenn, D. W., Brinkman, P., Schultz, M. J., Bergmans, D. C. J. J., Schnabel, R. M. & Bos, L. D. J., 1 Sept 2023, In: ERJ open research. 9, 5, 00214-2023.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Prognostic Value of the Radiographic Assessment of Lung Edema Score in Mechanically Ventilated ICU Patients

  Filippini, D. F. L., Hagens, L. A., Heijnen, N. F. L., Zimatore, C., Atmowihardjo, L. N., Schnabel, R. M., Schultz, M. J., Bergmans, D. C. J. J., Bos, L. D. J. & Smit, M. R., 1 Feb 2023, In: Journal of clinical medicine. 12, 4, 1252.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection

  Amsterdam UMC COVID-19 biobank study group, 1 Aug 2023, In: eBioMedicine. 94, p. 104729 104729.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

  COVID-STORM Clinicians, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID Clinicians, NIAID-USUHS COVID Study Group, Orchestra Working Group, Botta, M., de Bruin, S., Bulle, E., Dijkstra, M., Dongelmans, D. A., Dujardin, R. W. G., Goorhuis, B., Hafkamp, F., Hagens, L., Hamann, J., Paulus, F., & 11 othersPina-Fuentes, D. A. I., Raasveld, J., de Rotte, M. C. F. J., Schultz, M. J., Schrauwen, F. A. P., Slim, M. A., Smit, M., Stijnis, C. S., Stilma, W., Zwinderman, A. H. & Vlaar, A. P. J., 1 Dec 2023, In: Genome Medicine. 15, 1, p. 22 22.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  17 Citations (Scopus)

• Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study

  DARTS consortium, 1 Mar 2023, In: ERJ open research. 9, 2, 00427-2022.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)
• 2022

  Breath octane and acetaldehyde as markers for acute respiratory distress syndrome in invasively ventilated patients suspected to have ventilator-associated pneumonia

  Heijnen, N. F. L., Hagens, L. A., van Schooten, F-J., Bos, L. D. J., van der Horst, I. C. C., Mommers, A., Schultz, M. J., Smit, M. R., Bergmans, D. C. J. J., Smolinska, A. & Schnabel, R. M., 1 Jan 2022, In: ERJ open research. 8, 1, 00624-2021.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Improvement of an interobserver agreement of ARDS diagnosis by adding additional imaging and a confidence scale

  on behalf of the DARTS consortium, 31 Aug 2022, In: Frontiers in Medicine. 9, 950827.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19

  Amsterdam UMC Covid-19 Biobank & also on behalf of the Amsterdam UMC COVID-19 Biobank Study Group, 2022, In: Journal of pathology. 256, 3

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  22 Citations (Scopus)

• Lung Ultrasound Signs to Diagnose and Discriminate Interstitial Syndromes in ICU Patients: A Diagnostic Accuracy Study in Two Cohorts

  Heldeweg, M. L. A., Smit, M. R., Kramer-Elliott, S. R., Haaksma, M. E., Smit, J. M., Hagens, L. A., Heijnen, N. F. L., Jonkman, A. H., Paulus, F., Schultz, M. J., Girbes, A. R. J., Heunks, L. M. A., Bos, L. D. J. & Tuinman, P. R., 1 Nov 2022, In: Critical Care Medicine. 50, 11, p. 1607-1617 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  15 Citations (Scopus)

• Neurofilament light increases over time in severe COVID-19 and is associated with delirium

  Amsterdam UMC Covid-19 Biobank, 26 Jul 2022, In: Brain Communications. 4, 4, fcac195.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Prone Positioning Decreases Inhomogeneity and Improves Dorsal Compliance in Invasively Ventilated Spontaneously Breathing COVID-19 Patients—A Study Using Electrical Impedance Tomography

  Pierrakos, C., van der Ven, F. L. I. M., Smit, M. R., Hagens, L. A., Paulus, F., Schultz, M. J. & Bos, L. D. J., 1 Oct 2022, In: Diagnostics. 12, 10, 2281.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)
• 2021

  A lower global lung ultrasound score is associated with higher likelihood of successful extubation in invasively ventilated COVID-19 patients

  Pierrakos, C., Lieveld, A., Pisani, L., Smit, M. R., Heldeweg, M., Hagens, L. A., Smit, J., Haaksma, M., Veldhuis, L., Schmidt, R. W., Errico, G., Marinelli, V., Attou, R., David, C. E., Zimatore, C., Murgolo, F., Grasso, S., Mirabella, L., Cinnella, G., de Bels, D., & 3 othersSchultz, M. J., Tuinman, P-R. & Bos, L. D., 1 Dec 2021, In: The American journal of tropical medicine and hygiene. 105, 6, p. 1490-1497 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• Biological subphenotypes of acute respiratory distress syndrome may not reflect differences in alveolar inflammation

  BASIC consortium, 1 Feb 2021, In: Physiological reports. 9, 3, p. e14693

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• Biological subphenotypes of acute respiratory distress syndrome show prognostic enrichment in mechanically ventilated patients without acute respiratory distress syndrome

  MARS consortium, 15 Jun 2021, In: American journal of respiratory and critical care medicine. 203, 12, p. 1503-1511 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  47 Citations (Scopus)

• Development and validation of a point-of-care breath test for octane detection

  Hagens, L. A., Verschueren, A. R. M., Lammers, A., Heijnen, N. F. L., Smit, M. R., Nijsen, T. M. E., Geven, I., Schultz, M. J., Bergmans, D. C. J. J., Schnabel, R. M. & Bos, L. D. J., 21 Jul 2021, In: ANALYST. 146, 14, p. 4605-4614 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• Diagnosis of acute respiratory distress syndrome (DARTS) by bedside exhaled breath octane measurements in invasively ventilated patients: protocol of a multicentre observational cohort study

  Hagens, L. A., Heijnen, N. F. L., Smit, M. R., Verschueren, A. R. M., Nijsen, T. M. E., Geven, I., Schultz, M. J., Bergmans, D. C. J. J., Schnabel, R. M. & Bos, L. D. J., Aug 2021, In: Annals of Translational Medicine. 9, 15, p. 1262

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

  Aman, J., Duijvelaar, E., Botros, L., Kianzad, A., Schippers, J. R., Smeele, P. J., Azhang, S., Bartelink, I. H., Bayoumy, A. A., Bet, P. M., Boersma, W., Bonta, P. I., Boomars, K. A. T., Bos, L. D. J., van Bragt, J. J. M. H., Braunstahl, G-J., Celant, L. R., Eger, K. A. B., Geelhoed, J. J. M., van Glabbeek, Y. L. E., & 45 othersGrotjohan, H. P., Hagens, L. A., Happe, C. M., Hazes, B. D., Heunks, L. M. A., van den Heuvel, M., Hoefsloot, W., Hoek, R. J. A., Hoekstra, R., Hofstee, H. M. A., Juffermans, N. P., Kemper, E. M., Kos, R., Kunst, P. W. A., Lammers, A., van der Lee, I., van der Lee, E. L., Maitland-van der Zee, A-H., Mau Asam, P. F. M., Mieras, A., Muller, M., Neefjes, L., Nossent, E. J., Oswald, L. M. A., Overbeek, M. J., Pamplona, C., Paternotte, N., Pronk, N., de Raaf, M. A., van Raaij, B. F. M., Reijrink, M., Schultz, M. J., Serpa Neto, A., Slob, E. M., Smeenk, F. W. J. M., Smit, M. R., Smits, A. J., Stalenhoef, J. E., Tuinman, P. R., Vanhove, A. L. E. M., Wessels, J. N., van Wezenbeek, J. C. C., Vonk Noordegraaf, A., de Man, F. S. & Bogaard, H. J., Sept 2021, In: lancet. Respiratory medicine. 9, 9, p. 957-968 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  76 Citations (Scopus)

• Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research

  Bos, L. D. J., Artigas, A., Constantin, J-M., Hagens, L. A., Heijnen, N., Laffey, J. G., Meyer, N., Papazian, L., Pisani, L., Schultz, M. J., Shankar-Hari, M., Smit, M. R., Summers, C., Ware, L. B., Scala, R. & Calfee, C. S., 31 Mar 2021, In: European Respiratory Review. 30, 159, p. 1-11 11 p., 200317.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  36 Citations (Scopus)

• Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

  PRoVENT-COVID Collaborative Group, van Akkeren, J. P., Algoe, C. K., van Amstel, R. B., Baur, O. L., van de Berg, P., van den Berg, A. E., Bergmans, D. C. J. J., van den Bersselaar, D. I., Bertens, F. A., Bindels, A. J. G. H., de Boer, M. M., den Boer, S., Bogerd, M., Breel, J. S., de Bruin, H., de Bruin, S., Bruna, C. L., Buiteman-Kruizinga, L. A., Cremer, O. L., & 55 othersDetermann, R. M., Dieperink, W., Franke, H. S., Galek-Aldridge, M. S., de Graaff, M. J., Hagens, L. A., Haringman, J. J., van der Heide, S. T., van der Heiden, P. L. J., Heijnen, N. F. L., Hiel, S. J. P., Hoeijmakers, L. L., Hol, L., Hollmann, M. W., Hoogendoorn, M. E., van der Horst, R., Ie, E. L. K., Ivanov, D. P., Juffermans, N., Kho, E., de Klerk, E. S., Koopman-van Gemert, A. W. M. M., Koopmans, M., Kucukcelebi, S., Kuiper, M. A., de Lange, D. W., van Mourik, N., Nijbroek, S. G. L. H., Onrust, M., Oostdijk, E. A. N., Pennartz, C. J., Pisani, L., Purmer, I. M., Rettig, T. C. D., Roozeman, J. P., Schuijt, M. T. U., Sleeswijk, M. E., Smit, M. R., Spronk, P. E., Strang, A. C., Tuinman, P. R., Valk, C. M. A., Veen-Schra, F. L., Veldhuis, L. I., van Velzen, P., van der Ven, W. H., van Vliet, P., van der Voort, P. H. J., van Welie, L., Wesselink, H. J. F. T., van der Wier-Lubbers, H. H., van Wijk, B., Winters, T., Wong, W. Y. & van Zanten, A. R. H., 1 Feb 2021, In: The Lancet. Respiratory medicine. 9, 2, p. 139-148 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  187 Citations (Scopus)
• 2020

  Comparison of Linear and Sector Array Probe for Handheld Lung Ultrasound in Invasively Ventilated ICU Patients

  DARTS consortium, Dec 2020, In: Ultrasound in medicine & biology. 46, 12, p. 3249-3256 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)