Research output per year
Research output per year
Personal profile
Research interests
Curriculum Vitae
1991-1992: Research fellow at Harvard University, Boston, U.S.A. Department of Biochemistry, Boston at the laboratory of Prof. Dr. J. Strominger (Supervision Prof. E.A. Macintyre)
1992: Master Medical Biology, VU University, Amsterdam, The Netherlands.
1993-1998: Doctorate: PhD at the Netherlands Cancer Institute, Department of Immunology, Amsterdam, The Netherlands at the laboratory of Prof. Dr. J. Borst.Thesis defense at 01-09-1998 at Utrecht University (Promoter: Prof. R. Bernards).
1998-1999: Post-doctoral research fellow the Netherlands Cancer Institute (Prof. Dr. J. Borst)
1999-2005: Post-doctoral research fellow at the laboratory of Prof. Dr. H. Clevers, Hubrecht Institute, Laboratory of developmental biology and stem cell research, Utrecht, The Netherlands.
2005-2008: Post-doctoral research fellow at the laboratory of Prof. Dr. R. Bernards, Department of carcinogenesis, Netherlands Cancer Institute, Amsterdam, The Netherlands.
May 2008-May 2008 till present: Principle Investigator, Assistant Professor and head of the molecular diagnostic team at the department of Hematology, Head Prof. Dr. S. Zweegman. Vice-Head: Prof. Dr. G.J. Ossenkoppele. VU University Medical Center, The Netherlands.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Immunophenotypic aberrant hematopoietic stem cells in myelodysplastic syndromes: a biomarker for leukemic progression
van Spronsen, M. F., Hanekamp, D., Westers, T. M., van Gils, N., Vermue, E., Rutten, A., Jansen, J. H., Lissenberg-Witte, B. I., Smit, L., Schuurhuis, G. J. & van de Loosdrecht, A. A., Mar 2023, In: Leukemia. 37, 3, p. 680-690 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Targeting Acute Myeloid Leukemia with Venetoclax; Biomarkers for Sensitivity and Rationale for Venetoclax-Based Combination Therapies
Griffioen, M. S., de Leeuw, D. C., Janssen, J. J. W. M. & Smit, L., 1 Jul 2022, In: Cancers. 14, 14, 3456.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access7 Citations (Scopus) -
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters
van Gils, N., Verhagen, H. J. M. P., Broux, M., Martianez, T., Denkers, F., Vermue, E., Rutten, A., Csikos, T., Demeyer, S., Cil, M., Al, M., Cools, J., Janssen, J. J. W. M., Ossenkoppele, G. J., Menezes, R. X. & Smit, L., 16 Sept 2022, In: iScience. 25, 9, p. 105013 105013.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Bimodal expression of potential drug target CLL-1 (CLEC12A) on CD34+ blasts of AML patients
Ngai, L. L., Ma, C. Y., Maguire, O., Do, A. D., Robert, A., Logan, A. C., Griffiths, E. A., Nemeth, M. J., Green, C., Pourmohamad, T., van Kuijk, B. J., Snel, A. N., Kwidama, Z. W., Venniker-Punt, B., Cooper, J., Manz, M. G., Gjertsen, B. T., Smit, L., Ossenkoppele, G. J., Janssen, J. J. W. M., & 2 others, Sept 2021, In: European journal of haematology. 107, 3, p. 343-353 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 (SF3B1)-mutant myelodysplastic syndromes subtype
Duetz, C., Westers, T. M., in ’t Hout, F. E. M., Cremers, E. M. P., Alhan, C., Venniker-Punt, B., Visser-Wisselaar, H. A., Chitu, D. A., de Graaf, A. O., Smit, L., Jansen, J. H. & van de Loosdrecht, A. A., May 2021, In: British journal of haematology. 193, 4, p. 798-803 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus)