Lonneke van Vught

Research output

Research output per year 2013 2015 2016 2017 2018 2020 2021 2022 2023 2024

• 86 Article
• 9 Comment/Letter to the editor
• 5 Review article
• 1 Erratum/Corrigendum

Research output per year

Research output per year

Search results

• 2024

  Neurofilament light chain but not glial fibrillary acidic protein is a potential biomarker of overt hepatic encephalopathy in patients with cirrhosis

  de Wit, K., van Doorn, D. J., Mol, B., van Vught, L. A., Nevens, F., Beuers, U., Ponsioen, C. Y., Teunissen, C. E. & Takkenberg, R. B., 1 May 2024, In: Annals of hepatology. 29, 3, 101496.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Subphenotypes in critical illness: a priori biological rationale is key

  van Amstel, R. B. E., Cremer, O. L., van Vught, L. A. & Bos, L. D. J., 1 Feb 2024, In: Intensive care medicine. 50, 2, p. 299-301

  Research output: Contribution to journal › Comment/Letter to the editor › Academic
  1 Citation (Scopus)
• 2023

  25-Hydroxyvitamin D concentrations do not affect the humoral or cellular immune response following SARS-CoV-2 mRNA vaccinations

  Amsterdam UMC COVID-19 S3/HCW study group, 2023, (E-pub ahead of print) In: Vaccine.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• A Transient Inflammatory Response Induced by Lipopolysaccharide Infusion Lowers Markers of Endogenous Cholesterol and Bile Acid Synthesis in Healthy Normocholesterolemic Young Men

  Mashnafi, S., Baumgartner, S., Mensink, R. P., Perlee, D., van Vught, L. A., L?tjohann, D. & Plat, J., 1 Jan 2023, In: Biomedicines. 11, 1, 126.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

  Radboud University Medical Center (RUMC) and COUGH1 study group, in collaboration with the UMC COVID-19 S3/HCW study group & Fatebenefratelli-Sacco Infectious Diseases Physicians group, 15 Sept 2023, In: iScience. 26, 9, 107619.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19

  Ibelings, R., van den Brom, C. E. & the Amsterdam UMC COVID-19 biobank study group, 1 Sept 2023, In: Artery Research. 29, 3, p. 83-93 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Integrating biology into clinical trial design

  van Amstel, R. B. E., van Vught, L. A. & Bos, L. D. J., 1 Feb 2023, In: Current Opinion in Critical Care. 29, 1, p. 26-33 8 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  1 Citation (Scopus)

• Non-conventional immunomodulation in the management of sepsis

  Slim, M. A., Turgman, O., van Vught, L. A., van der Poll, T. & Wiersinga, W. J., 2023, (E-pub ahead of print) In: European Journal of Internal Medicine.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

• Pharmacokinetic analysis of vilobelimab, anaphylatoxin C5a and antidrug antibodies in PANAMO: a phase 3 study in critically ill, invasively mechanically ventilated COVID-19 patients

  the PANAMO study group, 1 Dec 2023, In: Intensive Care Medicine Experimental. 11, 1, p. 37 37.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection

  Amsterdam UMC COVID-19 biobank study group, 1 Aug 2023, In: eBioMedicine. 94, p. 104729 104729.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

  Fatebenefratelli-Sacco Infectious Diseases Physicians group & UMC COVID-19 S3/HCW study group, 1 Jan 2023, In: eBioMedicine. 87, p. 104408 104408.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• The predictive value of the modified early warning score for admission to the intensive care unit in patients with a hematologic malignancy – A multicenter observational study

  van Mourik, N., Oomen, J. J., van Vught, L. A., Biemond, B. J., van den Bergh, W. M., Blijlevens, N. M. A., Vlaar, A. P. J. & Müller, M. C. A., 1 Dec 2023, In: Intensive & Critical Care Nursing. 79, 103486.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes

  the MARS consortium, Nov 2023, In: Intensive care medicine. 49, 11, p. 1360-1369 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)
• 2022

  Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study

  van Gils, M. J., Lavell, A., van der Straten, K., Appelman, B., Bontjer, I., Poniman, M., Burger, J. A., Oomen, M., Bouhuijs, J. H., van Vught, L. A., Slim, M. A., Schinkel, M., Wynberg, E., van Willigen, H. D. G., Grobben, M., Tejjani, K., van Rijswijk, J., Snitselaar, J. L., Caniels, T. G., Vlaar, A. P. J., & 6 othersPrins, M., de Jong, M. D., de Bree, G. J., Sikkens, J. J., Bomers, M. K. & Sanders, R. W., 1 May 2022, In: PLoS medicine. 19, 5, e1003991.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  57 Citations (Scopus)

• Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial

  the Amsterdam UMC COVID-19 Biobank Investigators, 1 Dec 2022, In: Respiratory research. 23, 1, 6 p., 375.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

  Open Access
  7 Citations (Scopus)

• Association between age and the host response in critically ill patients with sepsis

  MARS consortium, 1 Dec 2022, In: Critical Care. 26, 1, 385.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Blood leukocyte transcriptomes in Gram-positive and Gram-negative community-acquired pneumonia

  MARS consortium, 1 Mar 2022, In: European respiratory journal. 59, 3

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Clinical sepsis phenotypes in critically ill COVID-19 patients

  Bruse, N., Kooistra, E. J., Jansen, A., van Amstel, R. B. E., de Keizer, N. F., Kennedy, J. N., Seymour, C., van Vught, L. A., Pickkers, P. & Kox, M., 1 Dec 2022, In: Critical Care. 26, 1, 244.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  11 Citations (Scopus)

• Complement activation in COVID-19 and targeted therapeutic options: A scoping review

  Lim, E. H. T., van Amstel, R. B. E., de Boer, V. V., van Vught, L. A., de Bruin, S., Brouwer, M. C., Vlaar, A. P. J. & van de Beek, D., 30 Jul 2022, (E-pub ahead of print) In: Blood Reviews. 100995.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  20 Citations (Scopus)

• COVID-19 Pathophysiology: An Opportunity to Start Appreciating Time-Dependent Variation

  van Vught, L. A. & Bos, L. D. J., 1 Mar 2022, In: American journal of respiratory and critical care medicine. 205, 5, p. 483-485 3 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation

  the MARS consortium & MARS consortium, 1 Dec 2022, In: Critical Care. 26, 1, p. 151 151.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients

  Brands, X., Uhel, F., van Vught, L. A., Wiewel, M. A., Hoogendijk, A. J., Lutter, R., Schultz, M. J., Scicluna, B. P. & van der Poll, T., 1 Jul 2022, In: PLOS ONE. 17, 7 July, e0271637.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol

  Kotsaki, A., Pickkers, P., Bauer, M., Calandra, T., Lupse, M., Wiersinga, W. J., Meylan, S., Bloos, F., van der Poll, T., Slim, M. A., van Mourik, N., Müller, M. C. A., van Vught, L., Vlaar, A. P. J., de Nooijer, A., Bakkerus, L., Weis, S., Antonakos, N., Netea, M. G. & Giamarellos-Bourboulis, E. J., 20 Dec 2022, In: BMJ Open. 12, 12, p. e067251

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19

  Amsterdam UMC Covid-19 Biobank & also on behalf of the Amsterdam UMC COVID-19 Biobank Study Group, 2022, In: Journal of pathology. 256, 3

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  22 Citations (Scopus)

• Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis

  the MARS consortium, Apr 2022, In: Journal of cellular and molecular medicine. 26, 7, p. 1896-1904 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Personalised immunotherapy in sepsis: a scoping review protocol

  Slim, M. A., van Mourik, N., Dionne, J. C., Oczkowski, S. J. W., Netea, M. G., Pickkers, P., Giamarellos-Bourboulis, E. J., Müller, M. C. A., van der Poll, T., Wiersinga, W. J., Vlaar, A. P. J. & van Vught, L. A., 9 May 2022, In: BMJ Open. 12, 5, p. e060411

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Real-world Evidence of the Effects of Novel Treatments for COVID-19 on Mortality: A Nationwide Comparative Cohort Study of Hospitalized Patients in the First, Second, Third, and Fourth Waves in the Netherlands

  Slim, M. A., Appelman, B., Peters-Sengers, H., Dongelmans, D. A., de Keizer, N. F., Schade, R. P., de Boer, M. G. J., Müller, M. C. A., Vlaar, A. P. J., Wiersinga, W. J. & van Vught, L. A., 1 Dec 2022, In: Open forum infectious diseases. 9, 12, ofac632.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• SARS-CoV-2 antibody prevalence and correlates of six ethnic groups living in Amsterdam, the Netherlands: A population-based cross-sectional study, June-October 2020

  Coyer, L., Boyd, A., Schinkel, J., Agyemang, C., Galenkamp, H., Koopman, A. D. M., Leenstra, T., Moll van Charante, E. P., Lok, A., Verhoeff, A., Zwinderman, A. H., Jurriaans, S., van Vught, L. A., Stronks, K., Prins, M. & van den Born, B-J. H., 6 Jan 2022, In: BMJ Open. 12, 1, 10 p., e052752.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study

  the MARS consortium, Jan 2022, In: Intensive care medicine. 48, 1, p. 92-102 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  32 Citations (Scopus)
• 2021

  Biological subphenotypes of acute respiratory distress syndrome show prognostic enrichment in mechanically ventilated patients without acute respiratory distress syndrome

  MARS consortium, 15 Jun 2021, In: American journal of respiratory and critical care medicine. 203, 12, p. 1503-1511 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  47 Citations (Scopus)

• Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis

  the MARS consortium, 1 Apr 2021, In: Journal of thrombosis and haemostasis. 19, 4, p. 1049-1063

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Cross-reactive antibodies after sars-cov-2 infection and vaccination

  Amsterdam UMC COVID-19 S3/HCW study group, 23 Nov 2021, In: eLife. 10, e70330.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  45 Citations (Scopus)

• Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination

  Amsterdam UMC COVID-19 S3/HCW study group, 1 Sept 2021, In: Science advances. 7, 36, p. eabj5365 eabj5365.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  59 Citations (Scopus)

• Inflammatory biomarkers at hospital discharge are associated with readmission and death in patients hospitalized for COVID-19

  Amsterdam UMC Covid-19 Biobank, Dec 2021, In: European journal of clinical microbiology & infectious diseases. 40, 12, p. 2677-2683 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Intracellular expression of granzymes A, B, K and M in blood lymphocyte subsets of critically ill patients with or without sepsis

  García-Laorden, M. I., Hoogendijk, A. J., Wiewel, M. A., van Vught, L. A., Schultz, M. J., Bovenschen, N., de Vos, A. F. & van der Poll, T., Aug 2021, In: Clinical and experimental immunology. 205, 2, p. 222-231 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Sepsis Subclasses: A Framework for Development and Interpretation

  Demerle, K. M., Angus, D. C., Baillie, J. K., Brant, E., Calfee, C. S., Carcillo, J., Chang, C-C. H., Dickson, R., Evans, I., Gordon, A. C., Kennedy, J., Knight, J. C., Lindsell, C. J., Liu, V., Marshall, J. C., Randolph, A. G., Scicluna, B. P., Shankar-Hari, M., Shapiro, N. I., Sweeney, T. E., & 10 othersTalisa, V. B., Tang, B., Thompson, B. T., Tsalik, E. L., van der Poll, T., van Vught, L. A., Wong, H. R., Yende, S., Zhao, H. & Seymour, C. W., May 2021, In: Critical Care Medicine. 49, 5, p. 748-759 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  76 Citations (Scopus)

• The circulatory small non-coding RNA landscape in community-acquired pneumonia on intensive care unit admission

  Khan, H. N., Jongejan, A., van Vught, L. A., Horn, J., Schultz, M. J., Zwinderman, A. H., Cremer, O. L., Bonten, M. J., van der Poll, T. & Scicluna, B. P., Aug 2021, In: Journal of cellular and molecular medicine. 25, 16, p. 7621-7630 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination

  Amsterdam UMC COVID-19 S3/HCW study group, 1 Oct 2021, In: eBioMedicine. 72, 103589.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  14 Citations (Scopus)
• 2020

  Alkaline phosphatase in pulmonary inflammation—a translational study in ventilated critically ill patients and rats

  for the BASIC study investigators & BASIC study investigators, 1 Dec 2020, In: Intensive Care Medicine Experimental. 8, Suppl 1, 46.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• Erratum: Predicting the clinical trajectory in critically ill patients with sepsis: A cohort study (Critical Care (2019) 2 (408) DOI: 10.1186/s13054-019-2687-z)

  behalf of the MARS consortium, 6 Feb 2020, In: Critical care (London, England). 24, 1, 41.

  Research output: Contribution to journal › Erratum/Corrigendum › Academic

  Open Access
  1 Citation (Scopus)

• Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study

  the MARS consortium, 1 Aug 2020, In: Intensive care medicine. 46, 8, p. 1576-1589 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  32 Citations (Scopus)

• Prognostic classification based on P/F and PEEP in invasively ventilated ICU patients with hypoxemia—insights from the MARS study

  MARS consortium & for the MARS consortium, 1 Dec 2020, In: Intensive Care Medicine Experimental. 8, Suppl 1, p. 43 43.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis

  Khan, H. N., Brands, X., Aufiero, S., Hoogendijk, A. J., Klarenbeek, A. M., van Engelen, T. S. R., Haak, B. W., van Vught, L. A., Horn, J., Schultz, M. J., Zwinderman, A. H., van der Poll, T. & Scicluna, B. P., 13 Jul 2020, In: Critical care (London, England). 24, 1, 423.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  12 Citations (Scopus)

• The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients

  for the BASIC–study group & BASIC–study group, 1 Dec 2020, In: Intensive Care Medicine Experimental. 8, Suppl 1, p. 74 74.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• The leukocyte non-coding RNA landscape in critically ill patients with sepsis

  Molecular Diagnosis and Risk Stratification in Sepsis (MARS) consortium & Nijrnberg, P., 11 Dec 2020, In: eLife. 9, p. 1-23 23 p., e58597.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  27 Citations (Scopus)

• The predictive validity for mortality of the driving pressure and the mechanical power of ventilation

  for the MARS consortium & MARS consortium, 1 Dec 2020, In: Intensive Care Medicine Experimental. 8, Suppl 1, p. 60 60.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)
• 2019

  Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study

  MARS consortium, 1 Dec 2019, In: Annals of intensive care. 9, 1, p. 55 55.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  82 Citations (Scopus)

• Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS

  MARS consortium, 1 Dec 2019, In: Annals of intensive care. 9, 1, 128.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  46 Citations (Scopus)

• Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

  the MARS consortium, 1 Dec 2019, In: Intensive Care Medicine Experimental. 7, 1, p. 58 58.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Kinase activity is impaired in neutrophils of sepsis patients

  Hoogendijk, A. J., van Vught, L. A., Wiewel, M. A., Fuhler, G. M., Belkasim-Bohoudi, H., Horn, J., Schultz, M. J., Scicluna, B. P., Peppelenbosch, M. P., van 't Veer, C., de Vos, A. F. & van der Poll, T., 2019, In: Haematologica. 104, 6, p. e233-e235

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

  Open Access
  7 Citations (Scopus)