Lucas Fleuren

Research output

Research output per year 2015 2021 2022 2023 2024

• 32 Article
• 3 Comment/Letter to the editor
• 1 Conference contribution
• 1 Erratum/Corrigendum
• 3 More
  • 1 Letter
  • 1 Review article
  • 1 Phd-Thesis - Research and graduation internal

Research output per year

Research output per year

Search results

• 2023

  Augmented intelligence facilitates concept mapping across different electronic health records

  Dam, T. A., Fleuren, L. M., Roggeveen, L. F., Otten, M., Biesheuvel, L., Jagesar, A. R., Lalisang, R. C. A., Kullberg, R. F. J., Hendriks, T., Girbes, A. R. J., Hoogendoorn, M., Thoral, P. J. & Elbers, P. W. G., 1 Nov 2023, In: International Journal of Medical Informatics. 179, 105233.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Determining and assessing characteristics of data element names impacting the performance of annotation using Usagi

  Dutch ICU Data Sharing Against COVID-19 Collaborators, 1 Oct 2023, In: International Journal of Medical Informatics. 178, 105200.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19

  Ibelings, R., van den Brom, C. E. & the Amsterdam UMC COVID-19 biobank study group, 1 Sept 2023, In: Artery Research. 29, 3, p. 83-93 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Evolution of Clinical Phenotypes of COVID-19 Patients During Intensive Care Treatment: An Unsupervised Machine Learning Analysis

  On behalf of the Dutch ICU Data Sharing Collaborators, 1 Jul 2023, In: Journal of intensive care medicine. 38, 7, p. 612-629 18 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death

  Amsterdam University Medical Center COVID-19 Biobank Study Group, Amsterdam UMC Covid-19 Biobank, Harris, V., Hollmann, M., Horn, J., Hovius, J. W., de Jong, M. D., Paulus, F., van der Poll, T., Raasveld, J., de Rotte, M. C. F. J., Schinkel, M., Schultz, M. J., Stijnis, C. S., van der Valk, M., Veelo, D., Zwinderman, A. H., Brouwer, M. C., Vlaar, A. P. J., van de Beek, D., & 3 othersvan der Wel, N. N., den Dunnen, J. & van't Veer, C., Oct 2023, In: Research and practice in thrombosis and haemostasis. 7, 7, 102213.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection

  Amsterdam UMC COVID-19 biobank study group, 1 Aug 2023, In: eBioMedicine. 94, p. 104729 104729.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

  COVID-STORM Clinicians, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID Clinicians, NIAID-USUHS COVID Study Group, Orchestra Working Group, Botta, M., de Bruin, S., Bulle, E., Dijkstra, M., Dongelmans, D. A., Dujardin, R. W. G., Goorhuis, B., Hafkamp, F., Hagens, L., Hamann, J., Paulus, F., & 11 othersPina-Fuentes, D. A. I., Raasveld, J., de Rotte, M. C. F. J., Schultz, M. J., Schrauwen, F. A. P., Slim, M. A., Smit, M., Stijnis, C. S., Stilma, W., Zwinderman, A. H. & Vlaar, A. P. J., 1 Dec 2023, In: Genome Medicine. 15, 1, p. 22 22.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  17 Citations (Scopus)
• 2022

  Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records

  Vagliano, I., Schut, M. C., Abu-Hanna, A., Dongelmans, D. A., de Lange, D. W., Gommers, D., Cremer, O. L., Bosman, R. J., Rigter, S., Wils, E-J., Frenzel, T., de Jong, R., Peters, M. A. A., Kamps, M. J. A., Ramnarain, D., Nowitzky, R., Nooteboom, F. G. C. A., de Ruijter, W., Urlings-Strop, L. C., Smit, E. G. M., & 29 othersMehagnoul-Schipper, D. J., Dormans, T., de Jager, C. P. C., Hendriks, S. H. A., Achterberg, S., Oostdijk, E., Reidinga, A. C., Festen-Spanjer, B., Brunnekreef, G. B., Cornet, A. D., van den Tempel, W., Boelens, A. D., Koetsier, P., Lens, J., Faber, H. J., Karakus, A., Entjes, R., de Jong, P., Rettig, T. C. D., Reuland, M. C., Arbous, S., Fleuren, L. M., Dam, T. A., Thoral, P. J., Lalisang, R. C. A., Tonutti, M., de Bruin, D. P., Elbers, P. W. G. & de Keizer, N. F., 1 Nov 2022, In: International Journal of Medical Informatics. 167, p. 104863 104863.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study

  Smit, J. M., Exterkate, L., van Tienhoven, A. J., Haaksma, M. E., Heldeweg, M. L. A., Fleuren, L., Thoral, P., Dam, T. A., Heunks, L. M. A., Gommers, D., Cremer, O. L., Bosman, R. J., Rigter, S., Wils, E-J., Frenzel, T., Vlaar, A. P., Dongelmans, D. A., de Jong, R., Peters, M., Kamps, M. J. A., & 32 othersRamnarain, D., Nowitzky, R., Nooteboom, F. G. C. A., de Ruijter, W., Urlings-Strop, L. C., Smit, E. G. M., Mehagnoul-Schipper, D. J., Dormans, T., de Jager, C. P. C., Hendriks, S. H. A., Achterberg, S., Oostdijk, E., Reidinga, A. C., Festen-Spanjer, B., Brunnekreef, G. B., Cornet, A. D., van den Tempel, W., Boelens, A. D., Koetsier, P., Lens, J., Faber, H. J., Karakus, A., Entjes, R., de Jong, P., Rettig, T. C. D., Arbous, S., Vonk, B., Machado, T., Girbes, A. R. J., Sieswerda, E., Elbers, P. W. G. & Tuinman, P. R., 1 Nov 2022, In: Shock. 58, 5, p. 358-365 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19

  Amsterdam UMC Covid-19 Biobank & also on behalf of the Amsterdam UMC COVID-19 Biobank Study Group, 2022, In: Journal of pathology. 256, 3

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  22 Citations (Scopus)

• Neurofilament light increases over time in severe COVID-19 and is associated with delirium

  Amsterdam UMC Covid-19 Biobank, 26 Jul 2022, In: Brain Communications. 4, 4, fcac195.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Pooled Population Pharmacokinetic Analysis for Exploring Ciprofloxacin Pharmacokinetic Variability in Intensive Care Patients

  the Dutch Antibiotic PK/PD Collaborators, Jun 2022, In: Clinical Pharmacokinetics. 61, 6, p. 869-879 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning

  Dutch ICU Data Sharing Against COVID-19 Collaborators & The Dutch ICU Data Sharing Against COVID-19 Collaborators, 20 Oct 2022, In: Annals of intensive care. 12, 1, p. 99 9 p., 99.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• Rapid Evaluation of Coronavirus Illness Severity (RECOILS) in intensive care: Development and validation of a prognostic tool for in-hospital mortality

  Plečko, D., Bennett, N., Mårtensson, J., Dam, T. A., Entjes, R., Rettig, T. C. D., Dongelmans, D. A., Boelens, A. D., Rigter, S., Hendriks, S. H. A., de Jong, R., Kamps, M. J. A., Peters, M., Karakus, A., Gommers, D., Ramnarain, D., Wils, E-J., Achterberg, S., Nowitzky, R., van den Tempel, W., & 27 othersde Jager, C. P. C., Nooteboom, F. G. C. A., Oostdijk, E., Koetsier, P., Cornet, A. D., Reidinga, A. C., de Ruijter, W., Bosman, R. J., Frenzel, T., Urlings-Strop, L. C., de Jong, P., Smit, E. G. M., Cremer, O. L., Mehagnoul-Schipper, D. J., Faber, H. J., Lens, J., Brunnekreef, G. B., Festen-Spanjer, B., Dormans, T., de Bruin, D. P., Lalisang, R. C. A., Vonk, S. J. J., Haan, M. E., Fleuren, L. M., Thoral, P. J., Elbers, P. W. G. & Bellomo, R., Jan 2022, In: Acta anaesthesiologica Scandinavica. 66, 1, p. 65-75 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)
• 2021

  Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

  COVID Human Genetic Effort, Imagine COVID-Group, Danish CHGE, CONSTANCES cohort, Etablissement du Sang study group, St James's Hospital, SARS CoV2 Interest group, 3C-Dijon Study, COVID Clinicians, CoV-Contact Cohort, NIAID Immune Response to COVID Group, Cerba HealthCare, French COVID Cohort Study Group, HGID Lab, COVID-STORM Clinicians, NH-COVAIR Study Group, The Danish Blood Donor Study (DBDS), The Milieu Intérieur Consortium & Amsterdam UMC Covid-19 Biobank, 19 Aug 2021, In: Science immunology. 6, 62, 26 p., eabl4340.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  327 Citations (Scopus)

• Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients

  Amsterdam UMC Covid-19 Biobank, 1 Jun 2021, In: Journal of clinical virology. 139, 104821.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  9 Citations (Scopus)

• Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf

  COVID-PREDICT-werkgroep, 1 Jan 2021, In: Nederlands Tijdschrift voor Geneeskunde. 165, 3, D5085.

  Research output: Contribution to journal › Article › Professional

  2 Citations (Scopus)

• Large-scale ICU data sharing for global collaboration: the first 1633 critically ill COVID-19 patients in the Dutch Data Warehouse: the first 1633 critically ill COVID-19 patients in the Dutch Data Warehouse

  Thoral, P. J., Roggeveen, L., van Diggelen, F., el Hassouni, A., Guzman, D. R., Bhulai, S., Driessen, R., Peppink, J., de Grooth, H. J., Zijlstra, G. J., van Tienhoven, A. J., van der Heiden, E., Spijkstra, J. J., van der Spoel, H., de Man, A., Klausch, T., de Vries, H., Neree tot Babberich, M. D., Thijssens, O., Wagemakers, L., & 54 othersBerend, J., Silva, V. C., Kullberg, B., Heunks, L., Slooter, A., Rettig, T. C. D., Reuland, M. C., van Manen, L., Montenij, L., van Bommel, J., van den Berg, R., van Geest, E., Hana, A., Simsek, S., Pickkers, P., van der Heiden, P., van Gemeren, C., Meinders, A. J., de Bruin, M., van Osch, F., Hendriks, S. H. A., Schroten, N., Arnold, K. S., Fijen, J. W., Festen-Spanjer, B., Achterberg, S., Lens, J., van Koesveld, J., van den Tempel, W., Simons, K. S., de Jager, C. P. C., Oostdijk, E., Labout, J., van der Gaauw, B., Reidinga, A. C., Koetsier, P., Cornet, A. D., Beishuizen, A., de Jong, P., Geutjes, D., Faber, H. J., Lutisan, J., Brunnekreef, G., Gemert, A. W. M. M. K. V., Entjes, R., van den Akker, R., Simons, B., Rijkeboer, A. A., Arbous, S., Aries, M., van den Oever, N. C. G., van Tellingen, M., Dutch ICU Data Sharing Collaborators & The Dutch ICU Data Sharing Collaborators, Apr 2021, In: Intensive care medicine. 47, 4, p. 478-481 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  13 Citations (Scopus)

• Predicting mortality of individual patients with COVID-19: a multicentre Dutch cohort

  The Dutch COVID-PREDICT research group, Janssen, M. L. F., Hubers, D., Fridgeirsson, E. A., Pina-Fuentes, D., van der Horst, I. C. C., Herff, C., Kubben, P., Marquering, H. A., de Kruif, M. D., Dormans, T., Fleuren, L. M., Schinkel, M., Noordzij, P. G., van den Bergh, J. P., Wyers, C. E., Buis, D. T. B., van den Hout, E. H. C., Reidinga, A. C., Rusch, D., & 7 othersSigaloff, K. C. E., Douma, R. A., de Haan, L., van den Oever, N. C. G., Rennenberg, R. J. M. W., Aries, M. J. H. & Beudel, M., 19 Jul 2021, In: BMJ Open. 11, 7, 13 p., e047347.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  16 Citations (Scopus)

• Predictors for extubation failure in COVID-19 patients using a machine learning approach

  Dutch ICU Data Sharing Against COVID-19 Collaborators, Cinà, G., Hovenkamp, H. & Noorduijn Londono, R., 27 Dec 2021, In: Critical care (London, England). 25, 1, p. 448 1 p., 448.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• Risk factors for adverse outcomes during mechanical ventilation of 1152 COVID-19 patients: a multicenter machine learning study with highly granular data from the Dutch Data Warehouse

  on behalf of Dutch ICU Data Sharing Against COVID-19 Collaborators, Cinà, G., de Keizer, N. F., Rademaker, E., Kuiper, M., Juffermans, N. & Dutch ICU Data Sharing Against COVID-19 Collaborators, 1 Dec 2021, In: Intensive Care Medicine Experimental. 9, 1, p. 32 15 p., 32.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Sharing is caring: How covid-19 led to large-scale collaboration for icudata.nl

  Elbers, P., Thoral, P., Dam, T. & Fleuren, L., 2021, In: Netherlands Journal of Critical Care. 29, 2, p. 85-86 2 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  2 Citations (Scopus)

• Some Patients Are More Equal Than Others: Variation in Ventilator Settings for Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

  Dam, T. A., de Grooth, H-J., Klausch, T., Fleuren, L. M., de Bruin, D. P., Entjes, R., Rettig, T. C. D., Dongelmans, D. A., Boelens, A. D., Rigter, S., Hendriks, S. H. A., de Jong, R., Kamps, M. J. A., Peters, M., Karakus, A., Gommers, D., Ramnarain, D., Wils, E-J., Achterberg, S., Nowitzky, R., & 36 othersvan den Tempel, W., de Jager, C. P. C., Nooteboom, F. G. C. A., Oostdijk, E., Koetsier, P., Cornet, A. D., Reidinga, A. C., de Ruijter, W., Bosman, R. J., Frenzel, T., Urlings-Strop, L. C., de Jong, P., Smit, E. G. M., Cremer, O. L., Mehagnoul-Schipper, D. J., Faber, H. J., Lens, J., Brunnekreef, G. B., Festen-Spanjer, B., Dormans, T., Dijkstra, A., Simons, B., Rijkeboer, A. A., Arbous, S., Aries, M., Beukema, M., Pretorius, D., van Raalte, R., van Tellingen, M., Gritters van den Oever, N. C., Lalisang, R. C. A., Tonutti, M., Girbes, A. R. J., Hoogendoorn, M., Thoral, P. J. & Elbers, P. W. G., Oct 2021, In: Critical Care Explorations. 3, 10, p. e0555

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

  Fleuren, L. M., Dam, T. A., Tonutti, M., de Bruin, D. P., Lalisang, R. C. A., Gommers, D., Cremer, O. L., Bosman, R. J., Rigter, S., Wils, E-J., Frenzel, T., Dongelmans, D. A., de Jong, R., Peters, M., Kamps, M. J. A., Ramnarain, D., Nowitzky, R., Nooteboom, F. G. C. A., de Ruijter, W., Urlings-Strop, L. C., & 38 othersSmit, E. G. M., Mehagnoul-Schipper, D. J., Dormans, T., de Jager, C. P. C., Hendriks, S. H. A., Achterberg, S., Oostdijk, E., Reidinga, A. C., Festen-Spanjer, B., Brunnekreef, G. B., Cornet, A. D., van den Tempel, W., Boelens, A. D., Koetsier, P., Lens, J., Faber, H. J., Karakus, A., Entjes, R., de Jong, P., Rettig, T. C. D., Arbous, S., Vonk, S. J. J., Fornasa, M., Machado, T., Houwert, T., Hovenkamp, H., Noorduijn-Londono, R., Quintarelli, D., Scholtemeijer, M. G., de Beer, A. A., Cina, G., Beudel, M., Herter, W. E., Girbes, A. R. J., Hoogendoorn, M., Thoral, P. J., Elbers, P. W. G. & Dutch ICU Data Sharing Against COVID-19 Collaborators, 23 Aug 2021, In: Critical Care. 25, 1, p. 304 304.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  22 Citations (Scopus)

• Transatlantic transferability of a new reinforcement learning model for optimizing haemodynamic treatment for critically ill patients with sepsis

  Roggeveen, L., el Hassouni, A., Ahrendt, J., Guo, T., Fleuren, L., Thoral, P., Girbes, A. RJ., Hoogendoorn, M. & Elbers, P. WG., 1 Feb 2021, In: Artificial Intelligence in Medicine. 112, 102003.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  15 Citations (Scopus)

• Why we should sample sparsely and aim for a higher target: Lessons from model-based therapeutic drug monitoring of vancomycin in intensive care patients

  Guo, T., van Hest, R. M., Fleuren, L. M., Roggeveen, L. F., Bosman, R. J., van der Voort, P. H. J., Girbes, A. R. J., Mathot, R. A. A., van Hasselt, J. G. C. & Elbers, P. W. G., Mar 2021, In: British journal of clinical pharmacology. 87, 3, p. 1234-1242 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)
• 2020

  Optimizing Predictive Performance of Bayesian Forecasting for Vancomycin Concentration in Intensive Care Patients

  Guo, T., van Hest, R. M., Zwep, L. B., Roggeveen, L. F., Fleuren, L. M., Bosman, R. J., van der Voort, P. H. J., Girbes, A. R. J., Mathot, R. A. A., Elbers, P. W. G. & van Hasselt, J. G. C., 1 Sept 2020, In: Pharmaceutical research. 37, 9, 171.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Right Dose, Right Now: Development of AutoKinetics for Real Time Model Informed Precision Antibiotic Dosing Decision Support at the Bedside of Critically Ill Patients

  Roggeveen, L. F., Guo, T., Driessen, R. H., Fleuren, L. M., Thoral, P., van der Voort, P. H. J., Girbes, A. R. J., Bosman, R. J. & Elbers, P., 15 May 2020, In: Frontiers in Pharmacology. 11, 646.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)
• 2019

  Clinically relevant pharmacokinetic knowledge on antibiotic dosing among intensive care professionals is insufficient: a cross-sectional study

  Fleuren, L. M., Roggeveen, L. F., Guo, T., Waldauf, P., van der Voort, P. H. J., Bosman, R. J., Swart, E. L., Girbes, A. R. J. & Elbers, P. W. G., 22 May 2019, In: Critical care (London, England). 23, 1, p. 185 185.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• External evaluation of population pharmacokinetic models of vancomycin in large cohorts of intensive care unit patients

  Guo, T., van Hest, R. M., Roggeveen, L. F., Fleuren, L. M., Thoral, P. J., Bosman, R. J., van der Voort, P. H. J., Girbes, A. R. J., Mathot, R. A. A. & Elbers, P. W. G., 1 May 2019, In: Antimicrobial agents and chemotherapy. 63, 5, e02543-18.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  37 Citations (Scopus)

• Right Dose Right Now: Bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock - Rationale and design of a multicenter randomized controlled superiority trial

  Roggeveen, L. F., Fleuren, L. M., Guo, T., Thoral, P., de Grooth, H. J., Swart, E. L., Klausch, T. L. T., van der Voort, P. H. J., Girbes, A. R. J., Bosman, R. J. & Elbers, P. W. G., 2019, In: Trials. 20, 1, 745.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  23 Citations (Scopus)

• Why physiology will continue to guide the choice between balanced crystalloids and normal saline: a systematic review and meta-analysis

  Zwager, C. L., Tuinman, P. R., de Grooth, H-J., Kooter, J., Ket, H., Fleuren, L. M. & Elbers, P. W. G., 2019, In: Critical care (London, England). 23, 1, p. 366

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  11 Citations (Scopus)