Projects per year
Personal profile
Research interests
Gene Therapy.
The focus of the research is to develop Adeno Associated liver directed gene therapy to treat inherited unconjugated hyperbilirubinemia. This research is partly funded by the Dutch Najjar foundation. Succeslfull application of AAV in this patients will also enable us to use this strategy to treat other inherited liver diseases.
specialisation
Gene therapy
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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Bosma P.J.: Novel therapies for liver disease
Bosma, P., ten Bloemendaal, L., Aronson, S., Bolier, A., van Dijk, R., Langedijk, J., Naik, J., Shi, X. & Berlingieri, S.
1/02/2007 → …
Project: Research
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Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients
Shi, X., Aronson, S. J., ten Bloemendaal, L., Duijst, S., Bakker, R. S., de Waart, D. R., Bortolussi, G., Collaud, F., Oude Elferink, R. P., Muro, A. F., Mingozzi, F., Ronzitti, G. & Bosma, P. J., 12 Mar 2021, In: Molecular therapy. Methods & clinical development. 20, p. 287-297 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access10 Citations (Scopus) -
Long-term effects of biliverdin reductase a deficiency in ugt1−/− mice: impact on redox status and metabolism
Bortolussi, G., Shi, X., Bloemendaal, L. T., Banerjee, B., de Waart, D. R., Baj, G., Chen, W., Oude Elferink, R. P., Beuers, U., Paulusma, C. C., Stocker, R., Muro, A. F. & Bosma, P. J., 1 Dec 2021, In: Antioxidants. 10, 12, 2029.Research output: Contribution to journal › Article › Academic › peer-review
Open Access6 Citations (Scopus) -
Low efficacy of recombinant SV40 in Ugt1a1-/- mice with severe inherited hyperbilirubinemia
Shi, X., Bortolussi, G., ten Bloemendaal, L., Duijst, S., Muro, A. F. & Bosma, P. J., 1 Apr 2021, In: PLOS ONE. 16, 4 April, e0250605.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Reduced spontaneous itch in mouse models of cholestasis
Langedijk, J., Bolier, R., Tolenaars, D., ten Bloemendaal, L., Duijst, S., de Waart, D., Beuers, U., Bosma, P. & Elferink, R. O., 1 Dec 2021, In: Scientific reports. 11, 1, 6127.Research output: Contribution to journal › Article › Academic › peer-review
Open Access6 Citations (Scopus) -
A Quantitative In Vitro Potency Assay for Adeno-Associated Virus Vectors Encoding for the UGT1A1 Transgene
Aronson, S. J., Bakker, R. S., Moenis, S., van Dijk, R., Bortolussi, G., Collaud, F., Shi, X., Duijst, S., ten Bloemendaal, L., Ronzitti, G., Muro, A. F., Mingozzi, F., Beuers, U. & Bosma, P. J., 11 Sept 2020, In: Molecular therapy. Methods & clinical development. 18, p. 250-258 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access10 Citations (Scopus)