Research output per year
Research output per year
Personal profile
Research interests
The focus of our research is to understand the molecular mechanisms that drive commitment of the hematopoietic stem cell (HSC) to a megakaryocytic-erythroid progenitor (MEP), and that stimulate subsequent expansion and differentiation of the erythroid and megakaryocytic compartments. The aim of our research is to restore healthy numbers of erythrocytes and platelets in patients with congenital anemia or thrombocytopenia. Thereto we study (i) the requirements for large scale production of erythrocytes and platelets to generate personalized transfusion products, and (ii) in mechanisms that are affected in congenital anemia or thrombocytopenia with the aim to find other solutions than erythrocyte or platelet transfusion.
specialisation
Hematopoiesis, erythropoiesis
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts
Horos, R., Ijspeert, H., Pospisilova, D., Sendtner, R., Andrieu-Soler, C., Taskesen, E., Nieradka, A., Cmejla, R., Sendtner, M., Touw, I. P. & von Lindern, M., 2012, In: Blood. 119, 1, p. 262-272Research output: Contribution to journal › Article › Academic › peer-review
136 Citations (Scopus) -
Molecular mechanisms of pathology and treatment in Diamond Blackfan Anaemia
Horos, R. & von Lindern, M., 2012, In: British journal of haematology. 159, 5, p. 514-527Research output: Contribution to journal › Review article › Academic › peer-review
49 Citations (Scopus) -
Assessing the translational landscape of myogenic differentiation by ribosome profiling
de Klerk, E., Fokkema, I. F. A. C., Thiadens, K. A. M. H., Goeman, J. J., Palmblad, M., den Dunnen, J. T., von Lindern, M. & 't Hoen, P. A. C., 2015, In: Nucleic Acids Research. 43, 9, p. 4408-4428Research output: Contribution to journal › Article › Academic › peer-review
39 Citations (Scopus) -
A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism
Paolini, N. A., Attwood, M., Sondalle, S. B., Vieira, C. M. D. S., van Adrichem, A. M., di Summa, F. M., O'Donohue, M-F., Gleizes, P-E., Rachuri, S., Briggs, J. W., Fischer, R., Ratcliffe, P. J., Wlodarski, M. W., Houtkooper, R. H., von Lindern, M., Kuijpers, T. W., Dinman, J. D., Baserga, S. J., Cockman, M. E. & MacInnes, A. W., 2017, In: American journal of human genetics. 100, 3, p. 506-522Research output: Contribution to journal › Article › Academic › peer-review
62 Citations (Scopus) -
Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment
Nieradka, A., Ufer, C., Thiadens, K., Grech, G., Horos, R., van Coevorden-Hameete, M., van den Akker, E., Sofi, S., Kuhn, H. & von Lindern, M., 2014, In: PLOS ONE. 9, 9, p. e104631Research output: Contribution to journal › Article › Academic › peer-review
20 Citations (Scopus)