1. Improving the understanding and management of co-morbidity and co-infection in people living with HIV
2. Epidemiology of HIV in the Netherlands

Since the inception of the AGEhIV cohort study in 2009 I have together with the study PI  prof. P. Reiss (Professor of Internal Medicine, in particular the complications of HIV treatment), acted as a senior clinical co-investigator of the study contributing to the design and excecution of a range of studies performed by successive PhD students on the study. (www.agehiv.nl) 

As of 2016 I acted as the principal investigator of the MC Free study which aims to eliminate hepatitis C infections in hiv-positive men who have sex with men. This study nicely complements the HIV transmission elimination Amsterdam (www.hteam.nl) aiming to reduce new HIV infections in Amsterdam. As of  2017  I am a member of H team's executive committee. Both MC Free and H-team are prominent examples of implementation research projects.

As of 2020 I am leading  a project to develop a national toolkit for peer-to-peer support in HIV care and initiated a PROMS-based program to improve the quality of care of people living with HIV at the Amsterdam UMC and DC clinics HIV-outpatient clinic.

From 2021  I am director of the Board of Stichting hiv monitoring (SHM)  foundation (ATHENA),an insititute that collects data on people living with HIV in the Netherlands.   Apart  from being responsible for  SHMs yearly monitoring report, which can be found at Home | Stichting HIV Monitoring (hiv-monitoring.nl) as a PI of the ATHENA cohort I collaborate with multiple international partners in large international consortia.