Marcel Spaargaren

(Principal Investigator), PhD

1990 …2021

Research activity per year

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Personal profile

Research interests

Pathogenesis of B-cell malignancies, in particular Non-Hodgkin Lymphoma (Diffuse Large B-cell Lymphoma and Mantle Cell Lymphoma), Chronic Lymphocytic Leukemia, Multiple Myeloma and Waldenström’s Macroglobulinemia, with a focus on signal transduction, cell adhesion and migration, and microenvironment-dependence, aiming for the discovery of novel therapeutic targets (e.g., by functional genomic CRISPR screens) and preclinical therapy development.

Specific interests:
- signal transduction
- cell proliferation and survival
- cell adhesion and migration
- tumor microenvironment-dependence

Favorite molecules:
- B-cell antigen receptor
- chemokines (e.g., CXCL12)
- HGF and MET
- WNT and beta-catenin
- heparan sulfate proteoglycans (e.g., Syndecan-1 and CD44)
- adhesion molecules (integrins and cadherins)
- kinases (e.g., Bruton’s tyrosine kinase)
- kinase inhibitors (e.g., ibrutinib and idelalisib)
- transcription factors (e.g., FOXP1)
- Bcl-2 family proteins

 

Specialisation

Oncology, Immunolgy

Network

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