Projects per year
Personal profile
Research interests
Prof. Schultz (1965) began his professional career when he joined the Department of Intensive Care in 2000 after completing a fellowship in Critical Care at the Amsterdam UMC (location AMC). Widely known and admired for his scientific productivity, he is one of the most highly cited Critical Care researchers in the world.
He is a founding member of the PROtective VENTilation Network, a group of international experts that performed several highly cited international multicenter randomized clinical trials of invasive ventilation, in surgery patients in the operating room, and in critically ill patients in the intensive care unit, and of CRIT CARE ASIA, a group of international experts that perform studies in intensive care units in resource-limited settings.
As a faculty member in the Department of Intensive Care at the Amsterdam UMC (location AMC), he is extensively sponsored by the ‘Netherlands Organization for Health Research and Development’ (NWO, ZonMw) since 2005. In 2006 he established the 'Laboratory of Experimental Intensive Care & Anesthesiology' (L·E·I·C·A). Dr. Schultz holds the Endowed Chair in Experimental Intensive Care at the University of Amsterdam since 2008. He oversaw enormous growth in research activity and optimized the operations of the research team in recent years. He currently works in close collaboration with the research groups in Dresden, Genova and Vienna.
He served as a leading investigator of numerous observational studies and randomized clinical trials (RCTs) in ICU and surgery patients, in high-income and low/middle-income countries, including the observational studies 'LAS VEGAS', 'LAMiNAR', 'COURSE', 'PRoVENT', 'PRoVENT-iMiC', 'PRoVENT-COVID', 'PRoAcT-COVID', 'PRoVaCT-COVID', 'PROXY-COVID', 'ENIRI', 'ENIO', 'BreathDx', 'DARTS', 'LUXoR', 'PRoFLUID/PRoFLUID-iMiC', and 'MARS/MARS-BASIC', the RCTs 'PROVHILO', 'PROBESE', 'PROTHOR', 'DESIGNATION', 'GENERATOR', 'HEPBURN', 'HiLoNALI', 'HiLoHeLu', 'PReVENT', 'NEBULAE', 'RELAx', 'ACTiVE', 'INTELLiSTREAM', 'AiRDRoP', 'PERFuSE', 'INTELLiPOWER', 'CONFIDENCE', and 'PEGASUS', and the individual patient data-analysis 'REPEAT', and 'PRoVENT-COP'. Soon two new studies are about to start, 'PRoVENT/WEAN-PED' and 'BIG APPLE', and a new trial is under development, named 'PERMISS'. Last but not least, he’s one of the leading researchers in the famICom project.
specialisation
Collaborations and top research areas from the last five years
Projects
- 4 Active
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Vlaar A.P.J: Transfusion related morbidity and mortality
Bosboom, J., Klanderman, R., Peters, A., van de Weerdt, E., Wijnberge, M., Vlaar, A., Hollmann, M., Juffermans, N., Schlack, W., Schultz, M. & Wiersinga, W.
1/06/2016 → …
Project: Research
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Horn J.: Neurology on the Intensive Care Unit
Horn, J., Hauck, N., Hollmann, M., Juffermans, N., Lagrand, W., Lirk, P., Nollet, F., Preckel, B., van der Schaaf, M., van Schaik, I., Schultz, M., Stevens, M., Verhamme, C., Zuurbier, C., Brevoord, D., Kerindongo, R., Admiraal, M., Sommers, J., Witteveen, E., Hofmeijer, J., van Putten, M. J. A. M., Ruijter, B. & van der Veen, A. J.
1/01/2013 → …
Project: Research
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Schultz M.J.: Prevention and treatment of organ failure in intensive care medicine
Admiraal, M., de Beer, F., Boshuizen, M., Eberl, S., Glas, G., Harmon, M., van Hezel, M., van der Hoeven, S., Juschten, J., Leopold, J. H., Lok, I., van Meenen, D., van Oort, P., Peters, A., Schouten, L., Simonis, F., van Someren Greve, F., van de Weerdt, E., Witteveen, E., Schultz, M., Binnekade, J., Dongelmans, D., Eberl, S., Hauck, N., Hollmann, M., Horn, J., Juffermans, N., Lagrand, W., Lirk, P., Paulus, F., Preckel, B., Stevens, M., Zuurbier, C., Tepaske, R., Veelo, D., Vlaar, A., Buchner - Doeven, J. & Tuip - de Boer, A.
1/01/2008 → …
Project: Research
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Hollmann M.W.: Organprotection
Hollmann, M., Fraessdorf, J., Hauck, N., Horn, J., van Hulst, R., Juffermans, N., Lirk, P., Preckel, B., Schlack, W., Schultz, M., Stevens, M., Veelo, D., Wartenberg, H., Wegener, J., Wille, F., Zuurbier, C., Avis, H., Vlaar, A., Buchner - Doeven, J., van Galen, A., Kerindongo, R., Tuip - de Boer, A., Bosboom, J., Brevoord, D., Doornebal, C., Eberl, S., Hermanns, H., ten Hoope, W., Hulst, B., Jong, W., Koers, L., Kooij, F., Mungroop, T., Nederlof, R., Picardi, S., Polderman, J., Posthuma, L., Ridderikhof, M., Smit, K., Sperna Weiland, N., Uthman, L., Wijnberge, M., Berger, M., Kessler, J., Cortjes, B., Hemmik, L., Ruijter, B. & Kronkel, M.
1/01/2007 → …
Project: Research
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High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial
AUTHOR GROUP, 2014, In: Lancet. 384, 9942, p. 495-503Research output: Contribution to journal › Article › Academic › peer-review
507 Citations (Scopus) -
Critical Care in Resource-Restricted Settings
Dondorp, A. M., Iyer, S. S. & Schultz, M. J., 2016, In: JAMA. 315, 8, p. 753-754Research output: Contribution to journal › Editorial › Academic › peer-review
50 Citations (Scopus) -
Association Between Use of Lung-Protective Ventilation With Lower Tidal Volumes and Clinical Outcomes Among Patients Without Acute Respiratory Distress Syndrome A Meta-analysis
Serpa Neto, A., Cardoso, S. O., Manetta, J. A., Pereira, V. G. M., Espósito, D. C., Pasqualucci, M. D. O. P., Damasceno, M. C. T. & Schultz, M. J., 2012, In: JAMA. 308, 16, p. 1651-1659Research output: Contribution to journal › Article › Academic › peer-review
633 Citations (Scopus) -
Incidence of mortality and morbidity related to postoperative lung injury in patients who have undergone abdominal or thoracic surgery: a systematic review and meta-analysis
Serpa Neto, A., Hemmes, S. N. T., Barbas, C. S. V., Beiderlinden, M., Fernandez-Bustamante, A., Futier, E., Hollmann, M. W., Jaber, S., Kozian, A., Licker, M., Lin, W-Q., Moine, P., Scavonetto, F., Schilling, T., Selmo, G., Severgnini, P., Sprung, J., Treschan, T., Unzueta, C., Weingarten, T. N., & 5 others , 2014, In: lancet. Respiratory medicine. 2, 12, p. 1007-1015Research output: Contribution to journal › Review article › Academic › peer-review
192 Citations (Scopus) -
Ventilation with lower tidal volumes as compared to conventional tidal volumes for patients without acute lung injury - a preventive randomized controlled trial
Determann, R. M., Royakkers, A., Wolthuis, E. K., Vlaar, A. P., Choi, G., Paulus, F., Hofstra, J. J., de Graaff, M. J., Korevaar, J. C. & Schultz, M. J., 2010, In: Critical Care. 14, 1, p. R1Research output: Contribution to journal › Article › Academic › peer-review
Open Access390 Citations (Scopus)
Datasets
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Early versus delayed initiation of renal replacement therapy for acute kidney injury: an updated systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials
Moreira, F. T. (Creator), Palomba, H. (Creator), De Freitas Chaves, R. C. (Contributor), Bouman, C. (Creator), Schultz, M. (Creator), Neto, A. S. (Contributor), Chaves, R. C. D. F. (Creator), Schultz, M. J. (Creator) & Neto, A. S. (Contributor), SciELO journals, 2018
DOI: 10.6084/m9.figshare.7216094, https://scielo.figshare.com/articles/dataset/Early_versus_delayed_initiation_of_renal_replacement_therapy_for_acute_kidney_injury_an_updated_systematic_review_meta-analysis_meta-regression_and_trial_sequential_analysis_of_randomized_controlled_trials/7216094
Dataset
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Early versus delayed initiation of renal replacement therapy for acute kidney injury: an updated systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials
Moreira, F. T. (Creator), Palomba, H. (Creator), De Freitas Chaves, R. C. (Contributor), Bouman, C. (Creator), Schultz, M. (Creator), Neto, A. S. (Contributor), Chaves, R. C. D. F. (Creator), Schultz, M. J. (Creator) & Neto, A. S. (Contributor), SciELO journals, 2018
DOI: 10.6084/m9.figshare.7216094.v1, https://scielo.figshare.com/articles/dataset/Early_versus_delayed_initiation_of_renal_replacement_therapy_for_acute_kidney_injury_an_updated_systematic_review_meta-analysis_meta-regression_and_trial_sequential_analysis_of_randomized_controlled_trials/7216094/1
Dataset
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Additional file 3 of The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis
Khan, H. N. (Creator), Brands, X. (Creator), Aufiero, S. (Creator), Hoogendijk, A. J. (Creator), Klarenbeek, A. M. (Creator), van Engelen, T. (Contributor), Haak, B. (Creator), van Vught, L. (Contributor), Horn, J. (Creator), Schultz, M. (Creator), Zwinderman, K. (Creator), van der Poll, T. (Contributor), Scicluna, B. P. (Creator), Hoogendijk, A. J. (Creator), Engelen, T. S. R. V. (Contributor), Vught, L. A. V. (Contributor), Horn, J. (Creator), Schultz, M. J. (Creator) & Scicluna, B. P. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12650773, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_The_circular_RNA_landscape_in_specific_peripheral_blood_mononuclear_cells_of_critically_ill_patients_with_sepsis/12650773
Dataset
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Supplementary Material for: Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill
Boshuizen, M. (Creator), Binnekade, J. M. (Creator), Nota, B. (Creator), Cremer, O. L. (Creator), Horn, J. (Creator), Schultz, M. (Creator), Juffermans, N. (Creator) & Cremer, O. L. (Creator), Karger Publishers, 2019
DOI: 10.6084/m9.figshare.8074352.v1, https://karger.figshare.com/articles/Supplementary_Material_for_Potential_of_Parameters_of_Iron_Metabolism_for_the_Diagnosis_of_Anemia_of_Inflammation_in_the_Critically_Ill/8074352/1
Dataset
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Additional file 3 of The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis
Khan, H. N. (Creator), Brands, X. (Creator), Aufiero, S. (Creator), Hoogendijk, A. J. (Creator), Klarenbeek, A. M. (Creator), van Engelen, T. (Contributor), Haak, B. (Creator), van Vught, L. (Contributor), Horn, J. (Creator), Schultz, M. (Creator), Zwinderman, K. (Creator), van der Poll, T. (Contributor), Scicluna, B. P. (Creator), Hoogendijk, A. J. (Creator), Engelen, T. S. R. V. (Contributor), Vught, L. A. V. (Contributor), Horn, J. (Creator), Schultz, M. J. (Creator) & Scicluna, B. P. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12650773.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_The_circular_RNA_landscape_in_specific_peripheral_blood_mononuclear_cells_of_critically_ill_patients_with_sepsis/12650773/1
Dataset