Mariëlle van Breemen

Research activity per year

specialisation

Stabilizing the exposure of neutralization epitopes on HIV-1 envelope glycoprotein trimer vaccines

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

1 Active

HIV vaccine research aimed at the induction of neutralizing antibodies
Brouwer, P., van Haaren, M., Del Moral Sanchez, I., Schorcht, A., de Taeye, S., Torrents de la Pena, A., Sanders, R., van Gils, M., Medina Ramirez, M., Bontjer, I., van Breemen, M. & Burger, J.
1/09/2010 → …
Project: Research

21 Article
2 Chapter
1 Editorial

Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
Caniels, T. G., Medina-Ramírez, M., Zhang, J., Sarkar, A., Kumar, S., LaBranche, A., Derking, R., Allen, J. D., Snitselaar, J. L., Capella-Pujol, J., Sánchez, I. D. M., Yasmeen, A., Diaz, M., Aldon, Y., Bijl, T. P. L., Venkatayogi, S., Martin Beem, J. S., Newman, A., Jiang, C., Lee, W-H., & 18 othersPater, M., Burger, J. A., van Breemen, M. J., de Taeye, S. W., Rantalainen, K., LaBranche, C., Saunders, K. O., Montefiori, D., Ozorowski, G., Ward, A. B., Crispin, M., Moore, J. P., Klasse, P. J., Haynes, B. F., Wilson, I. A., Wiehe, K., Verkoczy, L. & Sanders, R. W., 18 Apr 2023, In: Cell Reports Medicine. 4, 4, 101003.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access

5 Citations (Scopus)
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
Maisonnasse, P., Aldon, Y., Marc, A., Marlin, R., Dereuddre-Bosquet, N., Kuzmina, N. A., Freyn, A. W., Snitselaar, J. L., Gonçalves, A., Caniels, T. G., Burger, J. A., Poniman, M., Bontjer, I., Chesnais, V., Diry, S. G., Iershov, A., Ronk, A. J., Jangra, S., Rathnasinghe, R., Brouwer, P. J. M., & 31 othersBijl, T. P. L., van Schooten, J., Brinkkemper, M., Liu, H., Yuan, M., Mire, C. E., van Breemen, M. J., Contreras, V., Naninck, T., Lemaître, J., Kahlaoui, N., Relouzat, F., Chapon, C., Ho Tsong Fang, R., McDanal, C., Osei-Twum, M., St-Amant, N., Gagnon, L., Montefiori, D. C., Wilson, I. A., Ginoux, E., de Bree, G. J., García-Sastre, A., Schotsaert, M., Coughlan, L., Bukreyev, A., van der Werf, S., Guedj, J. R., Sanders, R. W., van Gils, M. J. & le Grand, R., 1 Dec 2021, In: Nature communications. 12, 1, 6097.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access

27 Citations (Scopus)
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
Brouwer, P. J. M., Brinkkemper, M., Maisonnasse, P., Dereuddre-Bosquet, N., Grobben, M., Claireaux, M., de Gast, M., Marlin, R., Chesnais, V., Diry, S. G., Allen, J. D., Watanabe, Y., Giezen, J. M., Kerster, G., Turner, H. L., van der Straten, K., van der Linden, C. A., Aldon, Y., Naninck, T., Bontjer, I., & 27 othersBurger, J. A., Poniman, M., Mykytyn, A. Z., Okba, N. M. A., Schermer, E. E., van Breemen, M. J., Ravichandran, R., Caniels, T. G., van Schooten, J., Kahlaoui, N., Contreras, V., Lemaître, J., Chapon, C., Fang, R. H. T., Villaudy, J., Sliepen, K., van der Velden, Y. U., Haagmans, B. L., de Bree, G. J., Ginoux, E., Ward, A. B., Crispin, M., King, N. P., van der Werf, S., van Gils, M. J., le Grand, R. & Sanders, R. W., 4 Mar 2021, In: Cell. 184, 5, p. 1188-1200.e19 36 p., 365726.
Research output: Contribution to journal › Article › Academic

Open Access

114 Citations (Scopus)
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates
Cottrell, C. A., van Schooten, J., Bowman, C. A., Yuan, M., Oyen, D., Shin, M., Morpurgo, R., van der Woude, P., van Breemen, M., Torres, J. L., Patel, R., Gross, J., Sewall, L. M., Copps, J., Ozorowski, G., Nogal, B., Sok, D., Rakasz, E. G., Labranche, C., Vigdorovich, V., & 11 othersChristley, S., Carnathan, D. G., Sather, D. N., Montefiori, D., Silvestri, G., Burton, D. R., Moore, J. P., Wilson, I. A., Sanders, R. W., Ward, A. B. & van Gils, M. J., 1 Aug 2020, In: PLoS pathogens. 16, 8, e1008753.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access

42 Citations (Scopus)
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
Brouwer, P. J. M., Caniels, T. G., van der Straten, K., Snitselaar, J. L., Aldon, Y., Bangaru, S., Torres, J. L., Okba, N. M. A., Claireaux, M., Kerster, G., Bentlage, A. E. H., van Haaren, M. M., Guerra, D., Burger, J. A., Schermer, E. E., Verheul, K. D., van der Velde, N., van der Kooi, A., van Schooten, J., van Breemen, M. J., & 13 othersBijl, T. P. L., Sliepen, K., Aartse, A., Derking, R., Bontjer, I., Kootstra, N. A., Joost Wiersinga, W., Vidarsson, G., Haagmans, B. L., Ward, A. B., de Bree, G. J., Sanders, R. W. & van Gils, M. J., 7 Aug 2020, In: Science. 369, 6504, p. 643-650 8 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access

765 Citations (Scopus)

Crystal structure of H6 hemagglutinin G225D mutant from Taiwan (2013) H6N1 influenza virus in complex with 6'-SLN
de Vries, R. P. (Contributor), Tzarum, N. (Contributor), Peng, W. (Contributor), Thompson, A. J. (Contributor), Ambepitiya Wickramasinghe, I. N. (Contributor), de la Pena, A. T. T. (Contributor), van Breemen, M. (Contributor), Bouwman, K. M. (Contributor), Zhu, X. (Contributor), McBride, R. (Contributor), Yu, W. (Contributor), Sanders, R. (Contributor), Verheije, M. H. (Contributor), Wilson, I. A. (Contributor) & Paulson, J. C. (Contributor), Protein Data Bank (PDB), 14 Jun 2017
DOI: 10.2210/pdb5T0B, https://www.wwpdb.org/pdb?id=pdb_00005t0b
Dataset
Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTa
de Vries, R. P. (Contributor), Peng, W. (Contributor), Grant, O. C. (Contributor), Thompson, A. J. (Contributor), Zhu, X. (Contributor), Bouwman, K. M. (Contributor), de la Pena, A. T. T. (Contributor), van Breemen, M. (Contributor), Ambepitiya Wickramasinghe, I. N. (Contributor), de Haan, C. A. M. (Contributor), Yu, W. (Contributor), McBride, R. (Contributor), Sanders, R. (Contributor), Woods, R. J. (Contributor), Verheije, M. H. (Contributor), Wilson, I. A. (Contributor) & Paulson, J. C. (Contributor), Protein Data Bank (PDB), 24 May 2017
DOI: 10.2210/pdb5VJM, https://www.wwpdb.org/pdb?id=pdb_00005vjm
Dataset
Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTc
de Vries, R. P. (Contributor), Peng, W. (Contributor), Grant, O. C. (Contributor), Thompson, A. J. (Contributor), Zhu, X. (Contributor), Bouwman, K. M. (Contributor), de la Pena, A. T. T. (Contributor), van Breemen, M. (Contributor), Ambepitiya Wickramasinghe, I. N. (Contributor), de Haan, C. A. M. (Contributor), Yu, W. (Contributor), McBride, R. (Contributor), Sanders, R. (Contributor), Woods, R. J. (Contributor), Verheije, M. H. (Contributor), Wilson, I. A. (Contributor) & Paulson, J. C. (Contributor), Protein Data Bank (PDB), 24 May 2017
DOI: 10.2210/pdb5VJL, https://www.wwpdb.org/pdb?id=pdb_00005vjl
Dataset
Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9)
de Vries, R. P. (Contributor), Peng, W. (Contributor), Grant, O. C. (Contributor), Thompson, A. J. (Contributor), Zhu, X. (Contributor), Bouwman, K. M. (Contributor), de la Pena, A. T. T. (Contributor), van Breemen, M. (Contributor), Ambepitiya Wickramasinghe, I. N. (Contributor), de Haan, C. A. M. (Contributor), Yu, W. (Contributor), McBride, R. (Contributor), Sanders, R. (Contributor), Woods, R. J. (Contributor), Verheije, M. H. (Contributor), Wilson, I. A. (Contributor) & Paulson, J. C. (Contributor), Protein Data Bank (PDB), 24 May 2017
DOI: 10.2210/pdb5VJK, https://www.wwpdb.org/pdb?id=pdb_00005vjk
Dataset
Crystal structure of H6 hemagglutinin G225D mutant from Taiwan (2013) H6N1 influenza virus in complex with LSTa
de Vries, R. P. (Contributor), Tzarum, N. (Contributor), Peng, W. (Contributor), Thompson, A. J. (Contributor), Ambepitiya Wickramasinghe, I. N. (Contributor), de la Pena, A. T. T. (Contributor), van Breemen, M. (Contributor), Bouwman, K. M. (Contributor), Zhu, X. (Contributor), McBride, R. (Contributor), Yu, W. (Contributor), Sanders, R. (Contributor), Verheije, M. H. (Contributor), Wilson, I. A. (Contributor) & Paulson, J. C. (Contributor), Protein Data Bank (PDB), 14 Jun 2017
DOI: 10.2210/pdb5T0E, https://www.wwpdb.org/pdb?id=pdb_00005t0e
Dataset

Mariëlle van Breemen

Personal profile

specialisation

Expertise related to UN Sustainable Development Goals

Collaborations and top research areas from the last five years

Dive into details

HIV vaccine research aimed at the induction of neutralizing antibodies

Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Crystal structure of H6 hemagglutinin G225D mutant from Taiwan (2013) H6N1 influenza virus in complex with 6'-SLN

Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTa

Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTc

Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9)

Crystal structure of H6 hemagglutinin G225D mutant from Taiwan (2013) H6N1 influenza virus in complex with LSTa

Mariëlle van Breemen

Personal profile

specialisation

Expertise related to UN Sustainable Development Goals

Collaborations and top research areas from the last five years

Projects

Research output

Datasets