Projects per year
Personal profile
Research interests
My interest in brain function has led me to specialize on the synapse, the coding unit of the brain. I am fascinated by the intricate molecular machinery that synapses use to tightly control the release of neurotransmitter. Modulation of this machinery results in presynaptic plasticity processes that underlie information processing in the brain. Since realizing that genes I studied out of fundamental interest underly several neuro-developmental and -degenerative disorders, I strive to bridge the fields of synapse biology and clinical genetics by studying fundamental principles and disease mechanisms involving neurotransmitter release.
Collaborations and top research areas from the last five years
Projects
- 1 Finished
-
NWO VENI M. Meijer: Towards understanding developmental disorders at a cellular level
1/09/2019 → 1/09/2022
Project: Research
Research output
- 18 Article
-
Reduced MUNC18-1 Levels, Synaptic Proteome Changes, and Altered Network Activity in STXBP1-Related Disorder Patient Neurons
van Berkel, A. A., Lammertse, H. C. A., Öttl, M., Koopmans, F., Misra-Isrie, M., Meijer, M., Dilena, R., van Hasselt, P. M., Engelen, M., van Haelst, M., Smit, A. B., van der Sluis, S., Toonen, R. F. & Verhage, M., Jan 2024, In: Biological Psychiatry Global Open Science. 4, 1, p. 284-298 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes
Meijer, M., Öttl, M., Yang, J., Subkhangulova, A., Kumar, A., Feng, Z., van Voorst, T. W., Groffen, A. J., van Weering, J. R. T., Zhang, Y. & Verhage, M., 1 Dec 2024, In: Nature communications. 15, 1, p. 1-20 20 p., 2652.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
A reference human induced pluripotent stem cell line for large-scale collaborative studies
Pantazis, C. B., Yang, A., Lara, E., McDonough, J. A., Blauwendraat, C., Peng, L., Oguro, H., Kanaujiya, J., Zou, J., Sebesta, D., Pratt, G., Cross, E., Blockwick, J., Buxton, P., Kinner-Bibeau, L., Medura, C., Tompkins, C., Hughes, S., Santiana, M., Faghri, F., & 75 others , 1 Dec 2022, In: Cell Stem Cell. 29, 12, p. 1685-1702.e22 41 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access32 Citations (Scopus) -
A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity
Classen, J., Saarloos, I., Meijer, M., Sullivan, P. F. & Verhage, M., 21 Feb 2020, In: Scientific reports. 10, 1, p. 3181 1 p., 3181.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Doc2 proteins are not required for the increased spontaneous release rate in synaptotagmin-1-deficient neurons
Díez-Arazola, R., Meijer, M., Bourgeois-Jaarsma, Q., Niels Cornelisse, L., Verhage, M. & Groffen, A. J., 25 Mar 2020, In: Journal of neuroscience. 40, 13, p. 2606-2617 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus)
Prizes
-
Lundbeck project mini-symposium
M Meijer (Participant)
9 Nov 2020Activity: Participating in or organising an event › Conference › Academic
-
SfN Neuronline Virtual Conference
M Meijer (Participant)
27 Sept 2019Activity: Participating in or organising an event › Conference › Academic
-
A single-cell model for synaptic transmission in iPSC-derived human neurons
M Meijer (Speaker)
3 Jun 2019Activity: Lecture / Presentation › Academic
-
A single-cell model for synaptic transmission and plasticity in human iPSC-derived neurons.
M Meijer (Speaker)
10 Jan 2019Activity: Lecture / Presentation › Academic
-
A single-cell model for synaptic transmission in iPSC-derived human neurons
M Meijer (Speaker)
30 Sept 2019Activity: Lecture / Presentation › Academic