Projects per year
Personal profile
Research interests
Research line
The major focus of our group is HIV-1 pathogenesis, more specific the effect of dual HIV-1 infections. This research line started with the description of the first patient with a double HIV-1 superinfection, resulting in a triple infection with different subtype: B-B’-AE (van der Kuyl et al, NEJM 2005 352: 2557-9). Longitudinal analysis of the patient’s samples showed that all three strains remained present both in blood and seminal plasma for years and recombinant viruses were formed.
Studies using RNA- or retroviruses have indicated that superinfections and especially co-infections lead to an increase in viral fitness. We speculated that HIV-1 co- or superinfection, contributes to the process of fitness gain and possibly to higher virulence. Two HIV-1 positive patients, L and P, acquired an HIV-1 superinfection within half a year from their primary HIV-1 infection (Jurriaans et al, JAIDS 2008, 47:69-73), and were used in a study to compare the replicative fitness of the primary and superinfecting HIV-1 strains.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Berkhout B.: Virology
Berkhout, B., Cornelissen, M., van der Kuyl, A., van Hemert, F., Herrera Carrillo, E., van Montfort, T., Pasternak, A. O., van der Velden, Y., Vink, M., Zorgdrager, F., Brouwer, P., Gao, Z., van Haaren, M., Del Moral Sanchez, I., Overmars, R., Schorcht, A., Steba, G., de Taeye, S., Torrents de la Pena, A., Wang, G. & Klaver, B.
1/01/2006 → …
Project: Research
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External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection
ANRS CO3 Aquitaine Cohort, the Swiss HIV Cohort Study, EuroSIDA & ATHENA Observational Cohort Study, May 2023, In: Journal of Hepatology. 78, 5, p. 947-957 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
TMPRSS2 is a functional receptor for human coronavirus HKU1
Saunders, N., Fernandez, I., Planchais, C., Michel, V., Rajah, M. M., Baquero Salazar, E., Postal, J., Porrot, F., Guivel-Benhassine, F., Blanc, C., Chauveau-Le Friec, G., Martin, A., Grzelak, L., Oktavia, R. M., Meola, A., Ahouzi, O., Hoover-Watson, H., Prot, M., Delaune, D., Cornelissen, M., & 9 others , 7 Dec 2023, In: NATURE. 624, 7990, p. 207-214 8 p.Research output: Contribution to journal › Article › Academic › peer-review
4 Citations (Scopus) -
A highly virulent variant of HIV-1 circulating in the Netherlands
Netherlands ATHENA HIV Observational Cohort, BEEHIVE Collaboration & Netherlands ATHENA HIV Observational Cohort†, 4 Feb 2022, In: Science. 375, 6580, p. 540-545 6 p., A30.Research output: Contribution to journal › Article › Academic › peer-review
Open Access29 Citations (Scopus) -
Many but small hiv-1 non-b transmission chains in the netherlands
Bezemer, D., Blenkinsop, A., Hall, M., van Sighem, A., Cornelissen, M., Wessels, E., van Kampen, J., van de Laar, T., Reiss, P., Fraser, C. & Ratmann, O., 1 Jan 2022, In: AIDS. 36, 1, p. 83-94 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load
Zhao, L., Wymant, C., Blanquart, F., Golubchik, T., Gall, A., Bakker, M., Bezemer, D., Hall, M., Ong, S. H., Albert, J., Bannert, N., Fellay, J., Grabowski, M. K., Gunsenheimer-Bartmeyer, B., Günthard, H. F., Kivelä, P., Kouyos, R. D., Laeyendecker, O., Meyer, L., Porter, K., & 8 others , 2022, In: Virus evolution. 8, 1, veac022.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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Additional file 1: Table S1. of Widespread hepatitis B virus genotype G (HBV-G) infection during the early years of the HIV epidemic in the Netherlands among men who have sex with men
Cornelissen, M. (Creator), Zorgdrager, F. (Contributor), Bruisten, S. M. (Creator), Bakker, M. (Creator), Berkhout, B. (Creator) & van der Kuyl, A. (Contributor), Figshare, 2016
DOI: 10.6084/m9.figshare.c.3605381_d1.v1, https://springernature.figshare.com/articles/dataset/Additional_file_1_Table_S1_of_Widespread_hepatitis_B_virus_genotype_G_HBV-G_infection_during_the_early_years_of_the_HIV_epidemic_in_the_Netherlands_among_men_who_have_sex_with_men/4345610/1
Dataset
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Additional file 1: Table S1. of Widespread hepatitis B virus genotype G (HBV-G) infection during the early years of the HIV epidemic in the Netherlands among men who have sex with men
Cornelissen, M. (Creator), Zorgdrager, F. (Contributor), Bruisten, S. M. (Creator), Bakker, M. (Creator), Berkhout, B. (Creator) & van der Kuyl, A. (Contributor), Figshare, 2016
DOI: 10.6084/m9.figshare.c.3605381_d1, https://springernature.figshare.com/articles/dataset/Additional_file_1_Table_S1_of_Widespread_hepatitis_B_virus_genotype_G_HBV-G_infection_during_the_early_years_of_the_HIV_epidemic_in_the_Netherlands_among_men_who_have_sex_with_men/4345610
Dataset