1983 …2023

Research activity per year

Personal profile

Research interests

Research line
The major focus of our group is HIV-1 pathogenesis, more specific the effect of dual HIV-1 infections. This research line started with the description of the first patient with a double HIV-1 superinfection, resulting in a triple infection with different subtype: B-B’-AE (van der Kuyl et al, NEJM 2005 352: 2557-9). Longitudinal analysis of the patient’s samples showed that all three strains remained present both in blood and seminal plasma for years and recombinant viruses were formed.
Studies using RNA- or retroviruses have indicated that superinfections and especially co-infections lead to an increase in viral fitness. We speculated that HIV-1 co- or superinfection, contributes to the process of fitness gain and possibly to higher virulence. Two HIV-1 positive patients, L and P, acquired an HIV-1 superinfection within half a year from their primary HIV-1 infection (Jurriaans et al, JAIDS 2008, 47:69-73), and were used in a study to compare the replicative fitness of the primary and superinfecting HIV-1 strains.

 

specialisation

virology, especially retroviruses

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or