Projects per year
Personal profile
Research interests
The van Gils lab is committed to make a lasting impact on the field of vaccine immunology. Our mission is to comprehend the underlying immunology behind vaccination, in particular the elicitation of antibody responses. These antibody responses are vital in the protection against infectious diseases and the major goal in vaccine research is to induce potent antibodies. We believe that the protective effects of antibody responses are to a major extent imprinted during the first encounters of B and T cells with vaccines. Therefore, gaining knowledge and control over the initial interactions of vaccine candidates with B and T cells and the formation of germinal center responses, will guide the development and improvement of vaccines against infectious diseases. Therefore, we focus on determining phenotypic characteristics of B and Tfh cells and the interactions between these cells correlated with lifelong immunity after common childhood vaccines and after experimental vaccines. We use different techniques such as RNA sequencing, T and B cell receptor analysis and monoclonal antibody isolation to characterize the phenotype, affinity, and specificity of the antigen-specific B and T cells. Through this, we will provide new insights directed towards improving vaccines with the ultimate goal to elicit durable protective immune responses against infectious diseases, such as HIV, SARS-CoV-2, Hepatitis C virus and Influenza virus.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Virology, Universiteit van Amsterdam
1 Jan 2007 → 31 Dec 2011
Award Date: 1 Apr 2011
Master, Medical Pharmaceutical Sciences, Rijks Universiteit Groningen: Faculteit der Medische wetenschappen
1 Sept 2004 → 31 Aug 2006
Bachelor, Medical Pharmaceutical Science, Rijks Universiteit Groningen: Faculteit der Medische wetenschappen
1 Sept 2000 → 31 Aug 2004
External positions
Associate Editor for NPJ Vaccines
1 Jun 2022 → …
Board Member, The Netherlands Conference on HIV Pathogenesis
1 Jan 2020 → 31 Dec 2026
Member, Amsterdam UMC Research strategy advisory board
1 Jan 2019 → 31 Dec 2020
Member, Amsterdam Young Academy (AYA)
1 Jan 2018 → 31 Dec 2022
Keywords
- QR355 Virology
- QR180 Immunology
Collaborations and top research areas from the last five years
Projects
- 3 Active
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HIV vaccine research aimed at the induction of neutralizing antibodies
Brouwer, P., van Haaren, M., Del Moral Sanchez, I., Schorcht, A., de Taeye, S., Torrents de la Pena, A., Sanders, R., van Gils, M., Medina Ramirez, M., Bontjer, I., van Breemen, M. & Burger, J.
1/09/2010 → …
Project: Research
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Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
Brouwer, P. J. M., Caniels, T. G., van der Straten, K., Snitselaar, J. L., Aldon, Y., Bangaru, S., Torres, J. L., Okba, N. M. A., Claireaux, M., Kerster, G., Bentlage, A. E. H., van Haaren, M. M., Guerra, D., Burger, J. A., Schermer, E. E., Verheul, K. D., van der Velde, N., van der Kooi, A., van Schooten, J., van Breemen, M. J., & 13 others , 7 Aug 2020, In: Science. 369, 6504, p. 643-650 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access765 Citations (Scopus) -
A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern
RECoVERED Study Group, 18 Jan 2022, In: Cell Reports Medicine. 3, 1, 100486.Research output: Contribution to journal › Article › Academic › peer-review
Open Access13 Citations (Scopus) -
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
Maisonnasse, P., Aldon, Y., Marc, A., Marlin, R., Dereuddre-Bosquet, N., Kuzmina, N. A., Freyn, A. W., Snitselaar, J. L., Gonçalves, A., Caniels, T. G., Burger, J. A., Poniman, M., Bontjer, I., Chesnais, V., Diry, S. G., Iershov, A., Ronk, A. J., Jangra, S., Rathnasinghe, R., Brouwer, P. J. M., & 31 others , 1 Dec 2021, In: Nature communications. 12, 1, 6097.Research output: Contribution to journal › Article › Academic › peer-review
Open Access27 Citations (Scopus) -
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates
Cottrell, C. A., van Schooten, J., Bowman, C. A., Yuan, M., Oyen, D., Shin, M., Morpurgo, R., van der Woude, P., van Breemen, M., Torres, J. L., Patel, R., Gross, J., Sewall, L. M., Copps, J., Ozorowski, G., Nogal, B., Sok, D., Rakasz, E. G., Labranche, C., Vigdorovich, V., & 11 others , 1 Aug 2020, In: PLoS pathogens. 16, 8, e1008753.Research output: Contribution to journal › Article › Academic › peer-review
Open Access42 Citations (Scopus) -
Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in nonhuman primates
van Schooten, J., van Haaren, M. M., Li, H., McCoy, L. E., Havenar-Daughton, C., Cottrell, C. A., Burger, J. A., van der Woude, P., Helgers, L. C., Tomris, I., Labranche, C. C., Montefiori, D. C., Ward, A. B., Burton, D. R., Moore, J. P., Sanders, R. W., Crotty, S., Shaw, G. M. & van Gils, M. J., 1 Aug 2021, In: PLoS pathogens. 17, 8, e1009736.Research output: Contribution to journal › Article › Academic › peer-review
Open Access10 Citations (Scopus)
Datasets
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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-04
Wu, N. C. (Contributor), Yuan, M. (Contributor), Liu, H. (Contributor), Lee, C. D. (Contributor), Zhu, X. (Contributor), Bangaru, S. (Contributor), Torres, J. L. (Contributor), Caniels, T. (Contributor), Brouwer, P. J. M. (Contributor), van Gils, M. (Contributor), Sanders, R. (Contributor), Ward, A. B. (Contributor) & Wilson, I. A. (Contributor), Protein Data Bank (PDB), 26 Aug 2020
DOI: 10.2210/pdb7JMO, https://www.wwpdb.org/pdb?id=pdb_00007jmo
Dataset
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Lassa virus glycoprotein construct (Josiah GPC-I53-50A) in complex with LAVA01 antibody
Brouwer, P. J. M. (Contributor), Antanasijevic, A. (Contributor), Ronk, A. J. (Contributor), Müller-Kräuter, H. (Contributor), Watanabe, Y. (Contributor), Claireaux, M. (Contributor), Perrett, H. R. (Contributor), Bijl, T. P. L. (Contributor), Grobben, M. (Contributor), Umotoy, J. (Contributor), Schriek, A. I. (Contributor), Burger, J. (Contributor), Tejjani, K. (Contributor), Lloyd, N. M. (Contributor), Steijaert, T. H. (Contributor), van Haaren, M. M. (Contributor), Sliepen, K. (Contributor), de Taeye, S. (Contributor), van Gils, M. (Contributor), Crispin, M. (Contributor), Strecker, T. (Contributor), Bukreyev, A. (Contributor), Ward, A. B. (Contributor) & Sanders, R. (Contributor), Protein Data Bank (PDB), 12 Oct 2022
DOI: 10.2210/pdb7SGF, https://www.wwpdb.org/pdb?id=pdb_00007sgf
Dataset
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Structure of 35O22 Fab, a HIV-1 neutralizing antibody
Huang, J. (Contributor), Kang, B. H. (Contributor), Pancera, M. (Contributor), Lee, J. H. (Contributor), Tong, T. (Contributor), Feng, Y. (Contributor), Imamichi, H. (Contributor), Georgiev, I. S. (Contributor), Chuang, G. (Contributor), Druz, A. (Contributor), Doria-Rose, N. A. (Contributor), Laub, L. (Contributor), Sliepen, K. (Contributor), van Gils, M. (Contributor), De La Peña, A. T. (Contributor), Derking, R. (Contributor), Klasse, P. (Contributor), Migueles, S. A. (Contributor), Bailer, R. T. (Contributor), Alam, M. (Contributor), Pugach, P. (Contributor), Haynes, B. F. (Contributor), Wyatt, R. T. (Contributor), Sanders, R. (Contributor), Binley, J. M. (Contributor), Ward, A. B. (Contributor), Mascola, J. R. (Contributor), Kwong, P. D. (Contributor) & Connors, M. (Contributor), Protein Data Bank (PDB), 3 Sept 2014
DOI: 10.2210/pdb4TOY, https://www.wwpdb.org/pdb?id=pdb_00004toy
Dataset
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Crystal structure of 354NC102 Fab
Freund, N. T. (Contributor), Wang, H. (Contributor), Scharf, L. (Contributor), Nogueira, L. (Contributor), Horwitz, J. A. (Contributor), Bar-On, Y. (Contributor), Golijanin, J. (Contributor), Sievers, S. A. (Contributor), Sok, D. (Contributor), Cai, H. (Contributor), Lorenzi, J. C. C. (Contributor), Halper-Stromberg, A. (Contributor), Toth, I. (Contributor), Piechocka-Trocha, A. (Contributor), Gristick, H. B. (Contributor), van Gils, M. (Contributor), Sanders, R. (Contributor), Wang, L. (Contributor), Seaman, M. S. (Contributor), Burton, D. R. (Contributor), Gazumyan, A. (Contributor), Walker, B. D. (Contributor), West, A. P. (Contributor), Bjorkman, P. J. (Contributor) & Nussenzweig, M. C. (Contributor), Protein Data Bank (PDB), 1 Feb 2017
DOI: 10.2210/pdb5UEL, https://www.wwpdb.org/pdb?id=pdb_00005uel
Dataset
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AMC018 SOSIP.v4.2 in complex with PGV04 Fab
Schorcht, A. (Contributor), Cottrell, C. A. (Contributor), Pugach, P. (Contributor), Ringe, R. P. (Contributor), Han, A. X. (Contributor), Allen, J. D. (Contributor), van den Kerkhof, T. L. G. M. (Contributor), Seabright, G. E. (Contributor), Schermer, E. E. (Contributor), Ketas, T. J. (Contributor), Burger, J. (Contributor), van Schooten, J. (Contributor), LaBranche, C. C. (Contributor), Ozorowski, G. (Contributor), de Val, N. (Contributor), Bader, D. L. V. (Contributor), Schuitemaker, H. (Contributor), Russell, C. A. (Contributor), Montefiori, D. C. (Contributor), van Gils, M. (Contributor), Crispin, M. (Contributor), Klasse, P. J. (Contributor), Ward, A. B. (Contributor), Moore, J. P. (Contributor) & Sanders, R. (Contributor), Protein Data Bank (PDB), 15 Sept 2021
DOI: 10.2210/pdb7RSN, https://www.wwpdb.org/pdb?id=pdb_00007rsn
Dataset