Projects per year
Personal profile
specialisation
Macrophages, regulation of gene expression, enhancer function, atherosclerosis.
Research interests
My research focusses on the transcriptional and epigenetic regulation of macrophages in health and (inflammatory or cardiovascular) disease. In particular, I am interested how gene enhancers function: which transcriptional regulators activate enhancers when macrophages are exposed to disease-associated signals, what genetic variants affect enhancer activity and how does this in turn result in differential gene expression?
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Postdoctoral Fellow, University of California, San Diego (UCSD), Department of Cellular and Molecular Medicine, La Jolla, CA, USA
1 Dec 2016 → 1 Sept 2021
Keywords
- QR180 Immunology
- genetic variation
- macrophages
- atherosclerosis
- enhancers
- transcription factors
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation
Reilly, N. A., Sonnet, F., Dekkers, K. F., Kwekkeboom, J. C., Sinke, L., Hilt, S., Suleiman, H. M., Hoeksema, M. A., Mei, H., van Zwet, E. W., Everts, B., Ioan-Facsinay, A., Jukema, J. W. & Heijmans, B. T., 19 Apr 2024, In: iScience. 27, 4, 109496.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
CD40L modulates CD4+ T-cell activation through receptor for activated C kinase 1
van Os, B. W., Vos, W. G., Bosmans, L. A., van Tiel, C. M., Toom, M. D., Beckers, L., Admiraal, M., Hoeksema, M. A., de Winther, M. P. & Lutgens, E., Dec 2023, In: European journal of immunology. 53, 12, p. e2350520 2350520.Research output: Contribution to journal › Article › Academic › peer-review
-
Editorial: Transcriptional regulation of macrophage function
Czimmerer, Z., Patsalos, A. & Hoeksema, M. A., 2023, In: Frontiers in immunology. 14, p. 1321064 1321064.Research output: Contribution to journal › Editorial › Academic › peer-review
Open Access -
Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages
van Wouw, S. A. E., van den Berg, M., el Ouraoui, M., Meurs, A., Kingma, J., Ottenhoff, R., Loix, M., Hoeksema, M. A., Prange, K., Pasterkamp, G., Hendriks, J. J. A., Bogie, J. F. J., van Klinken, J. B., Vaz, F. M., Jongejan, A., de Winther, M. P. J. & Zelcer, N., 1 Feb 2023, In: Journal of Lipid Research. 64, 2, p. 100325 1 p., 100325.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
The regulatory landscape of macrophage interferon signaling in inflammation
Siebeler, R., de Winther, M. P. J. & Hoeksema, M. A., 1 Aug 2023, In: Journal of allergy and clinical immunology. 152, 2, p. 326-337 12 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access1 Citation (Scopus)
Datasets
-
Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4
Hoeksema, M. (Creator), NCBI GEO, 19 Oct 2020
DOI: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159630
Dataset
-
Genome-wide analysis of bone marrow-derived macrophage (BMDM) priming by Ifng and Ifnb.
Hoeksema, M. (Creator), NCBI GEO, 11 Aug 2014
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE60290
Dataset
Activities
- 2 Membership of committee
-
ACS - Atherosclerosis & Ischemic Syndromes (Organisational unit)
Marten Hoeksema (Chair)
1 Jan 2023 → …Activity: Membership › Membership of committee › Academic
-
AII - Inflammatory diseases (Organisational unit)
Marten Hoeksema (Chair)
1 Jul 2022 → …Activity: Membership › Membership of committee › Academic
Press/Media
-
ERC StG for Marten Hoeksema
28/02/2023 → 7/03/2023
1 item of Media coverage, 1 Media contribution
Press/Media: Press / Media