Projects per year
AMC Department of Neurology
The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovasculair disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.
Infection & Inflammation
We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the era's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.
The focus of Dr. Brouwer’s research is on neurological infectious diseases, including bacterial meningitis, viral meningitis, chronic meningitis and neuroborreliosis. To this aim he has set up a nation-wide genetic association study on community-acquired bacterial meningitis (MeninGene study) and a study on suspected meningitis and encephalitis patients (PACEM study).
During his PhD Dr. Brouwer studied host genetic factors influencing bacterial meningitis in the nationwide cohort study on culture proven bacterial meningitis. By March 2017, 2300 patients have been included in this ongoing study. With this study we showed that adjunctive dexamethasone has successfully been implemented in the Netherlands, leading to a nationwide reduction of mortality and morbidity of bacterial meningitis. Furthermore, we identified common genetic variants in complement component 3 and 5 that influence susceptibility and outcome of bacterial meningitis. In several translational research projects we used clinical and genetic data to study pathofysiology of bacterial meningitis and identify new adjunctive treatments.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Hoogleraar Neurologie, in het bijzonder de diagnostiek van neurologische infectieziekten (AMC-UvA), Amsterdam UMC - University of Amsterdam
Award Date: 28 Jun 2022
Collaborations and top research areas from the last five years
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van de Beek, D., Brouwer, M., Eftimov, F., van der Kooi, A., van Schaik, I., Verhamme, C., Bijlsma, M., Ferwerda, B., Valls Seron, M., Jaspers, V., Costerus, J., Dorresteijn, K., Fritz, D., Hoogland, I., Jim, K., Kasanmoentalib, E., Kloek, A., Koopmans, M., Kremer, P., Schoenmaker, N., van Veen, K., Vermeij, J., Westendorp, W., Westhoff, D., Zock, E. & Schut, E.
1/12/2010 → …
Brouwer, M. C., Thwaites, G. E., Tunkel, A. R. & van de Beek, D., 2012, In: Lancet. 380, 9854, p. 1684-1692
Research output: Contribution to journal › Article › Academic › peer-review185 Citations (Scopus)
Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitisBrouwer, M. C., Meijers, J. C. M., Baas, F., van der Ende, A., Pfister, H-W., Giese, A., van de Beek, D. & Koedel, U., 2014, In: Acta Neuropathologica. 127, 4, p. 553-564
Research output: Contribution to journal › Article › Academic › peer-review14 Citations (Scopus)
282 Citations (Scopus)
van de Beek, D., Cabellos, C., Dzupova, O., Esposito, S., Klein, M., Kloek, A. T., Leib, S. L., Mourvillier, B., Ostergaard, C., Pagliano, P., Pfister, H. W., Read, R. C., Sipahi, O. R. & Brouwer, M. C., 2016, In: Clinical Microbiology and Infection. 22, Suppl. 3, p. S37-S62
Research output: Contribution to journal › Article › Academic › peer-review491 Citations (Scopus)
Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitisSavva, A., Brouwer, M. C., Roger, T., Valls Serón, M., le Roy, D., Ferwerda, B., van der Ende, A., Bochud, P-Y., van de Beek, D. & Calandra, T., 2016, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113, 13, p. 3597-3602
Research output: Contribution to journal › Article › Academic › peer-review49 Citations (Scopus)