Nataliya G. Yeremenko

(Principal Investigator), PhD

20032022

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Research interests

Research of my team is focused on the cellular and molecular pathways of IL-23/IL-17-immune axis in spondyloarthritis (SpA), a prevalent chronic rheumatic condition characterized by inflammation and abnormal new bone formation. Using gene expression profiling of SpA synovitis we identified a striking disease-specific myofibroblast signature and found that these synovial stromal cells express IL-23A in vivo and in vitro when exposed to cellular stress. Therefore we propose that stressed stromal cells can act as primary drivers of IL-23/IL-17-mediated tissue inflammation and remodelling. We are studying the function of stromal-derived IL-23A. In parallel we are investigating mechanisms of production and function of IL-17D, another stromal-derived member of IL-17 family.

The second line of research is devoted to understanding of the mechanisms regulating the breach of peripheral tolerance in rheumatoid arthritis (RA), chronic autoimmune disease where autoreactive B and T cells play a central role. Here we focused on the transcriptional co-activator Bob1. Based on our human and experimental data, we hypothesize that Bob1 contributes to RA pathogenesis by facilitating the generation of pathogenic T and B cells in RA synovium where they promote the broadening and maturation of the autoimmune response. We are studying function of Bob1 in human primary B and T cells in vitro and in vivo in experimental autoimmune arthritis, where we created a mouse with inducible overexpression of Bob1-targeted to B and/or T cells.

 

 

Specialisation

Translational Research. Rheumatology.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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