Projects per year
Personal profile
Research interests
Research of my team is focused on the cellular and molecular pathways of IL-23/IL-17-immune axis in spondyloarthritis (SpA), a prevalent chronic rheumatic condition characterized by inflammation and abnormal new bone formation. Using gene expression profiling of SpA synovitis we identified a striking disease-specific myofibroblast signature and found that these synovial stromal cells express IL-23A in vivo and in vitro when exposed to cellular stress. Therefore we propose that stressed stromal cells can act as primary drivers of IL-23/IL-17-mediated tissue inflammation and remodelling. We are studying the function of stromal-derived IL-23A. In parallel we are investigating mechanisms of production and function of IL-17D, another stromal-derived member of IL-17 family.
The second line of research is devoted to understanding of the mechanisms regulating the breach of peripheral tolerance in rheumatoid arthritis (RA), chronic autoimmune disease where autoreactive B and T cells play a central role. Here we focused on the transcriptional co-activator Bob1. Based on our human and experimental data, we hypothesize that Bob1 contributes to RA pathogenesis by facilitating the generation of pathogenic T and B cells in RA synovium where they promote the broadening and maturation of the autoimmune response. We are studying function of Bob1 in human primary B and T cells in vitro and in vivo in experimental autoimmune arthritis, where we created a mouse with inducible overexpression of Bob1-targeted to B and/or T cells.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Baeten D.L.P.: Immunopathology of chronic inflammatory arthritis
Baeten, D., van Duivenvoorde, L., den Dunnen, J., Fehres, C., Yeremenko, N., Blijdorp, I., Knaup, V., Pots, D., van Tok, M., Angiolilli, C., Chen, S., Hansen, I., Hoepel, W., de Jong, J., Kaaij, M. H., Kabala, P., Kraal, L., Levels, M., Maracle, C., van Mens, L., Musters, A., Newling, M., Noordenbos, T. & de Winter, J.
1/01/2008 → …
Project: Research
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The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation
Levels, M. J., van Tok, M. N., Cantaert, T., Cañete, J. D., Kroese, F. G. M., Germar, K., Spits, H., Baeten, D. L. P. & Yeremenko, N. G., 2017, In: Arthritis & rheumatology (Hoboken, N.J.). 69, 4, p. 750-762Research output: Contribution to journal › Article › Academic › peer-review
11 Citations (Scopus) -
Human mast cells capture, store, and release bioactive, exogenous IL-17A
Noordenbos, T., Blijdorp, I., Chen, S., Stap, J., Mul, E., Cañete, J. D., Lubberts, E., Yeremenko, N. & Baeten, D., 2016, In: Journal of leukocyte biology. 100, 3, p. 453-462Research output: Contribution to journal › Article › Academic › peer-review
70 Citations (Scopus) -
Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis
Yeremenko, N., Noordenbos, T., Cantaert, T., van Tok, M., van de Sande, M., Cañete, J. D., Tak, P. P. & Baeten, D., 2013, In: Arthritis and rheumatism. 65, 1, p. 174-185Research output: Contribution to journal › Article › Academic › peer-review
58 Citations (Scopus) -
Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis
Noordenbos, T., Yeremenko, N., Gofita, I., van de Sande, M., Tak, P. P., Caňete, J. D. & Baeten, D., 2012, In: Arthritis and rheumatism. 64, 1, p. 99-109Research output: Contribution to journal › Article › Academic › peer-review
245 Citations (Scopus) -
The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis
Yeremenko, N., Paramarta, J. E. & Baeten, D., 2014, In: Current Opinion in Rheumatology. 26, 4, p. 361-370Research output: Contribution to journal › Review article › Academic › peer-review
78 Citations (Scopus)
Activities
- 11 Keynote speaker, invited speaker or speaker
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Structural characterization of PSI-IsiA complexes in iron-stressed cyanobacteria
N. Yeremenko (Speaker), R. Kouril (Speaker), J.A. Ihalainen (Speaker), S. D'Haene (Speaker), N. van Oosterwijk (Speaker), H.C.P. Matthijs (Speaker), J. Dekker (Speaker) & E.J. Boekema (Speaker)
27 Aug 2004Activity: Lecture / Presentation › Keynote speaker, invited speaker or speaker › Academic
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Gene array for better understanding of PSI and cyclic electron transfer.
N. Yeremenko (Speaker) & H.C.P. Matthijs (Speaker)
5 Jun 2003Activity: Lecture / Presentation › Keynote speaker, invited speaker or speaker › Academic
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New developments in the study of PSI cyclic electron transfer
N. Yeremenko (Speaker) & H.C.P. Matthijs (Speaker)
29 May 2003Activity: Lecture / Presentation › Keynote speaker, invited speaker or speaker › Academic
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PSI trimers from Synechocystis PCC 6803 lacking the PsaF and PsaJ subinits bind an IsiA ring of seventeen units.
N. Yeremenko (Speaker), R. Houril (Speaker), S. D'Haene (Speaker), A.E. Yakushevska (Speaker), W. Keegstra (Speaker), H.C.P. Matthijs (Speaker), J.P. Dekker (Speaker) & E.J. Boekema (Speaker)
2 Sept 2003Activity: Lecture / Presentation › Keynote speaker, invited speaker or speaker › Academic
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Identification of the antimycin A sensitive site and the mechanism for Photosystem I driven cyclic electron flow in the cyanobacterium Synechocystis PCC 6803.
H.C.P. Matthijs (Speaker) & N. Yeremenko (Speaker)
2 Sept 2003Activity: Lecture / Presentation › Keynote speaker, invited speaker or speaker › Academic