Projects per year
Personal profile
specialisation
venous thromboembolism, deep vein thrombosis, pulmonary embolism, epidemiology, anticoagulation
Research interests
My research mainly focuses on the epidemiology, diagnosis, prediction, and treatment of venous thromboembolism, in particular in patients with cancer. We have an interest in developing risk assessment tools to cancer patients at high risk of venous thromboembolism, by using both clinical data and genetic information from tumor biopsies.
I am also interested in cardiovascular complications in cancer patients, in particular as a result of immune checkpoint inhibition. We study the effects of immune checkpoint inhibition on atherosclerosis and hypercoagulability in clinical studies.
Finally, I am involved in clinical studies evaluating the efficacy and safety of factor XI inhibitors, a novel class of anticoagulants that may be associated with a lower risk of bleeding than tradiational anticoagulation.
Collaborations and top research areas from the last five years
Projects
- 2 Active
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Middeldorp S.: Vascular Medicine
Beenen, L., Bistervels, I., Bleker, S., Brekelmans, M., Cunha, M., Diemer, F. S., van Es, N., Haan, H., Horjus, D., Karamat, F., Kraaijpoel, N., van Mens, T., Scheres, L., Middeldorp, S., Coppens, M. & Thijs, W.
1/01/2011 → …
Project: Research
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Büller H.R.: Venous and arterial thromboembolic diseases
Buller, H., Middeldorp, S., Bleker, S., van Es, N. & Kraaijpoel, N.
1/01/2006 → …
Project: Research
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Discharge from the emergency department and outpatient clinic in cancer patients with acute symptomatic and incidental pulmonary embolism: A multicenter retrospective cohort study
Guman, N. A. M., Kaptein, F. H. J., Lohle, S. B., Mairuhu, A. T. A., Klok, F. A., Huisman, M. V., Kamphuisen, P. W. & van Es, N., 1 Jan 2024, In: Thrombosis research. 233, p. 181-188 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Tailored anticoagulant treatment after a first venous thromboembolism: protocol of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study - cohort-based randomised controlled trial
Burggraaf-van Delft, J. L. I., van Rein, N., Bemelmans, R. H. H., van den Berg, J-W. K., Bruggeman, C. Y., Cloos-van Balen, M., Coppens, M., Eefting, M., Ende-Verhaar, Y., van Es, N., van Guldener, C., de Jong, W. K., Kleijwegt, F., Koster, T., Kroon, C., Kuipers, S., Leentjens, J., Luijten, D., Mairuhu, A. T. A., Meijer, K., & 7 others , 23 Mar 2024, In: BMJ Open. 14, 3, p. e078676Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Accuracy of physicians’ intuitive risk estimation in the diagnostic management of pulmonary embolism: an individual patient data meta-analysis
van Maanen, R., Martens, E. S. L., Takada, T., Roy, P-M., de Wit, K., Parpia, S., Kraaijpoel, N., Huisman, M. V., Wells, P. S., le Gal, G., Righini, M., Freund, Y., Galipienzo, J., van Es, N., Blom, J. W., Moons, K. G. M., Rutten, F. H., van Smeden, M., Klok, F. A., Geersing, G-J., & 1 others , Oct 2023, In: Journal of thrombosis and haemostasis. 21, 10, p. 2873-2883 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Contact system and intrinsic pathway activation in patients with advanced pancreatic cancer: a prospective cohort study
Bosch, F. T. M., Campello, E., Mulder, F. I., Ilich, A., Henderson, M. W., Prokopenko, Y., Gavasso, S., Pea, A., Salvia, R., Wilmink, H. W., Otten, H-M., van Es, N., Key, N. S., Büller, H. R. & Simioni, P., Oct 2023, In: Journal of thrombosis and haemostasis. 21, 10, p. 2863-2872 10 p.Research output: Contribution to journal › Article › Academic › peer-review
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Covariate-specific ROC curve analysis can accommodate differences between covariate subgroups in the evaluation of diagnostic accuracy
the IPD study team, Aug 2023, In: Journal of Clinical Epidemiology. 160, p. 14-23 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access