Projects per year
Personal profile
Research interests
Our research group within the L.E.I.C.A laboratory focusses primarily on protection of heart, blood vessels (endothelium) against temporary periods of no oxygen and inflammatory stress stimuli. Our main goal is to improve our understanding of the underlying mechanisms of different organ protection strategies with a focus on experiments in the heart, in vitro and in vivo and endothelial cells.
1. As diabetes impairs endothelial functions in both macro- and micro vessels, leading to development of multiple cardiovascular diseases we search to understand the mechanims that underlies different vascular protective strategies. Clinical studies have shown that sodium glucose co-transporter 2 inhibitors (SGLT-2i’s) significantly improve cardiovascular outcomes in diabetic and non-diabetic patients. Previous studies in our laboratory employing resting human endothelial cells suggest that SGLT-2i’s directly exert anti-inflammatory and anti-oxidative effects. We developed dynamic cellular models that mimic mechanical forces and disturbed shear stress induced endothelial dysfunctions in order to investigate the direct effects of SGLT-2i’s on activated endothelium.
2. Diabetic neuropathy is a neurodegenerative disorder that preferentially targets sensory neurons. Although highly prevalent, we still have large gaps in our knowledge concerning the pathophysiology and treatment of diabetic neuropathy. The discovery of induced pluripotent stem cells provided researchers with a new method of acquiring sensory neurons to develop disease-specific models. We aim to develop such a model of diabetic neuropathy and apply its data to the field of anesthesiology.
specialisation
vascular protection, endothelial integrity, inflammation, SGLT2i
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 7 Active
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Cerebral arterial gas embolism
Weenink, R., Preckel, B., Hauck, N., Fakkert, R. & van Hulst, R.
1/05/2021 → 31/12/2024
Project: Research
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Horn J.: Neurology on the Intensive Care Unit
Horn, J., Hauck, N., Hollmann, M., Juffermans, N., Lagrand, W., Lirk, P., Nollet, F., Preckel, B., van der Schaaf, M., van Schaik, I., Schultz, M., Stevens, M., Verhamme, C., Zuurbier, C., Brevoord, D., Kerindongo, R., Admiraal, M., Sommers, J., Witteveen, E., Hofmeijer, J., van Putten, M. J. A. M., Ruijter, B. & van der Veen, A. J.
1/01/2013 → …
Project: Research
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Zuurbier C.J.: Cell survival mechanisms in acute and chronic cardiovascular pathology
Jong, W., Nederlof, R., Uthman, L., Zuurbier, C., Hauck, N., Hollmann, M., Juffermans, N., Preckel, B., van Galen, A. & Gürel, E.
1/08/2012 → …
Project: Research
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Juffermans N.P.: Pathogenesis and treatment of organ failure in the critically ill
van Someren Greve, F., van de Weerdt, E., Wirtz, M., Juffermans, N., Hauck, N., Hollmann, M., Preckel, B., Zuurbier, C., Aslami, H., Vlaar, A., Binnekade, J., Tuip - de Boer, A., Boshuizen, M., Harmon, M., van Hezel, M., Hodiamont, C., Peters, A., Buchner, J. & van der Veen, A. Y.
1/11/2011 → …
Project: Research
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Preckel B.: Patient safety, procedural sedation, cardiovascular protection
Brevoord, D., Eberl, S., Hermanns, H., Hulst, B., Koers, L., Picardi, S., Polderman, J., Smit, K., Sperna Weiland, N., Preckel, B., Bergman, J., Eberl, S., Fockens, P., Fraessdorf, J., Hauck, N., Horn, J., van Hulst, R., Kooij, F., Lirk, P., van Samkar, G., Schlack, W., Stevens, M., Veelo, D., de Vries, J. H., Wegener, J., Zuurbier, C., van Dieren, S., Huhn, R., Oei, G., Weenink, R., van den Berg, T., Boer, C., Arthur Bouwman, R., van Dongen, E. H. P. A., Hofland, J., Houweling, P. & Kalkman, C. J.
1/01/2009 → …
Project: Research
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Canagliflozin inhibits inflammasome activation in diabetic endothelial cells – Revealing a novel calcium-dependent anti-inflammatory effect of canagliflozin on human diabetic endothelial cells
Li, X., Kerindongo, R. P., Preckel, B., Kalina, J-O., Hollmann, M. W., Zuurbier, C. J. & Weber, N. C., 1 Mar 2023, In: Biomedicine and Pharmacotherapy. 159, 114228.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies
Fakkert, R. A., Karlas, N., Schober, P., Weber, N. C., Preckel, B., van Hulst, R. A. & Weenink, R. P., 1 Dec 2023, In: Critical Care. 27, 1, 282.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
Pharmacological Cardioprotection against Ischemia Reperfusion Injury—The Search for a Clinical Effective Therapy
Wang, Q., Zuurbier, C. J., Huhn, R., Torregroza, C., Hollmann, M. W., Preckel, B., van den Brom, C. E. & Weber, N. C., 1 May 2023, In: Cells. 12, 10, 1432.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access3 Citations (Scopus) -
Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2
Chen, S., Wang, Q., Christodoulou, A., Mylonas, N., Bakker, D., Nederlof, R., Hollmann, M. W., Weber, N. C., Coronel, R., Wakker, V., Christoffels, V. M., Andreadou, I. & Zuurbier, C. J., 17 Jan 2023, In: Circulation. 147, 3, p. 276-279 4 p.Research output: Contribution to journal › Article › Academic › peer-review
16 Citations (Scopus) -
The Effects of Heparan Sulfate Infusion on Endothelial and Organ Injury in a Rat Pneumosepsis Model
van den Brink, D. P., Kleinveld, D. J. B., Bongers, A., Vos, J., Roelofs, J. T. H., Weber, N. C., van Buul, J. D. & Juffermans, N. P., 1 Oct 2023, In: Journal of Clinical Medicine. 12, 20, 6438.Research output: Contribution to journal › Article › Academic › peer-review
Open Access