Noam Zelcer

Research output

Research output per year 2000 2003 2004 2005 2006 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2022 2023 2023

• 71 Article
• 10 Review article
• 3 Editorial
• 1 Comment/Letter to the editor
• 2 More
  • 1 Erratum/Corrigendum
  • 1 Phd-Thesis - Research external and graduation internal

Research output per year

Research output per year

Search results

• 2023

  Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

  Hendrix, S., Kingma, J., Ottenhoff, R., Valiloo, M., Svecla, M., Sachdev, V., Kovac, K., Levels, J. H. M., Jongejan, A., de Boer, J. F., Kuipers, F., Rimbert, A., Norata, G. D., Loregger, A., Zelcer, N. & Zijlstra, L. F., 1 Dec 2023, In: Nature communications. 14, 1, 5181.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Hyperlipidaemia elicits an atypical, T helper 1-like CD4+T-cell response: A key role for very low-density lipoprotein

  van Os, B. W., Vos, W. G., Bosmans, L. A., van Tiel, C. M., Lith, S. C., den Toom, M. S., Beckers, L., Levels, J. H. M., van Wouw, S. A. E., Zelcer, N., Zaal, E. A., Berkers, C. R., van der Lest, C. H. A., Helms, J. B., Weber, C., Atzler, D., de Winther, M. P. J., Baardman, J. & Lutgens, E., 1 Mar 2023, In: European heart journal open. 3, 2, oead013.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2

  Vacondio, D., Nogueira Pinto, H., Coenen, L., Mulder, I. A., Fontijn, R., van het Hof, B., Fung, W. K., Jongejan, A., Kooij, G., Zelcer, N., Rozemuller, A. J., de Vries, H. E. & de Wit, N. M., 1 Nov 2023, In: Cell Death & Disease. 14, 11, p. 781 781.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages

  van Wouw, S. A. E., van den Berg, M., el Ouraoui, M., Meurs, A., Kingma, J., Ottenhoff, R., Loix, M., Hoeksema, M. A., Prange, K., Pasterkamp, G., Hendriks, J. J. A., Bogie, J. F. J., van Klinken, J. B., Vaz, F. M., Jongejan, A., de Winther, M. P. J. & Zelcer, N., 1 Feb 2023, In: Journal of Lipid Research. 64, 2, p. 100325 1 p., 100325.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2022

  Anti-Galectin-2 Antibody Treatment Reduces Atherosclerotic Plaque Size and Alters Macrophage Polarity

  Kane, J., Jansen, M., Hendrix, S., Bosmans, L. A., Beckers, L., Tiel, C. V., Gijbels, M., Zelcer, N., Vries, C. J. D., von Hundelshausen, P., Vervloet, M., Eringa, E., Horrevoets, A. J., Royen, N. V. & Lutgens, E., 1 Jun 2022, In: Thrombosis and haemostasis. 122, 6, p. 1047-1057 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• Defective Lipid Droplet–Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115

  Larsen, L. E., van den Boogert, M. A. W., Rios-Ocampo, W. A., Jansen, J. C., Conlon, D., Chong, P. L. E., Levels, J. H. M., Eilers, R. E., Sachdev, V. V., Zelcer, N., Raabe, T., He, M., Hand, N. J., Drenth, J. P. H., Rader, D. J., Stroes, E. S. G., Lefeber, D. J., Jonker, J. W. & Holleboom, A. G., 1 Jan 2022, In: Cellular and Molecular Gastroenterology and Hepatology. 13, 2, p. 583-597 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  9 Citations (Scopus)

• DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability

  Willemsen, L., Prange, K. H. M., Neele, A. E., van Roomen, C. P. A. A., Gijbels, M., Griffith, G. R., Toom, M. D., Beckers, L., Siebeler, R., Spann, N. J., Chen, H-J., Bosmans, L. A., Gorbatenko, A., van Wouw, S., Zelcer, N., Jacobs, H., van Leeuwen, F. & de Winther, M. P. J., 22 Nov 2022, In: Cell reports. 41, 8, 111703.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)
• 2021

  Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity

  Clemente-Olivo, M. P., Habibe, J. J., Vos, M., Ottenhoff, R., Jongejan, A., Herrema, H., Zelcer, N., Kooijman, S., Rensen, P. C. N., van Raalte, D. H., Nieuwdorp, M., Eringa, E. C. & de Vries, C. J., 1 Aug 2021, In: Metabolism: Clinical and Experimental. 121, p. 1-14 14 p., 154815.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  12 Citations (Scopus)

• Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner

  Bogie, J. F. J., Vanmierlo, T., Vanmol, J., Timmermans, S., Mailleux, J., Nelissen, K., Wijnands, E., Wouters, K., Stinissen, P., Gustafsson, J-Å., Steffensen, K. R., Mulder, M., Zelcer, N. & Hendriks, J. J. A., 1 Nov 2021, In: Journal of autoimmunity. 124, 102723.

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)
• 2020

  Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

  Loregger, A., Raaben, M., Nieuwenhuis, J., Tan, J. M. E., Jae, L. T., van den Hengel, L. G., Hendrix, S., van den Berg, M., Scheij, S., Song, J-Y., Huijbers, I. J., Kroese, L. J., Ottenhoff, R., van Weeghel, M., van de Sluis, B., Brummelkamp, T. & Zelcer, N., 1 Dec 2020, In: Nature communications. 11, 1, 1128.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  28 Citations (Scopus)

• Regulation of intestinal LDLR by the LXR-IDOL axis

  van Loon, N. M., van Wouw, S. A. E., Ottenhoff, R., Nelson, J. K., Kingma, J., Scheij, S., Moeton, M. & Zelcer, N., 1 Dec 2020, In: Atherosclerosis. 315, p. 1-9 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  13 Citations (Scopus)

• Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

  Bogie, J. F. J., Grajchen, E., Wouters, E., Corrales, A. G., Dierckx, T., Vanherle, S., Mailleux, J., Gervois, P., Wolfs, E., Dehairs, J., van Broeckhoven, J., Bowman, A. P., Lambrichts, I., Gustafsson, J-Å., Remaley, A. T., Mulder, M., Swinnen, J. V., Haidar, M., Ellis, S. R., Ntambi, J. M., & 2 othersZelcer, N. & Hendriks, J. J. A., 4 May 2020, In: Journal of Experimental Medicine. 217, 5, e20191660.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  66 Citations (Scopus)

• Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site

  Martinelli, L., Adamopoulos, A., Johansson, P., Wan, P. T., Gunnarsson, J., Guo, H., Boyd, H., Zelcer, N. & Sixma, T. K., 25 Sept 2020, In: Journal of Biological Chemistry. 295, 39, p. 13570-13583 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

  Tan, J. M. E., van der Stoel, M. M., van den Berg, M., van Loon, N. M., Moeton, M., Scholl, E., van der Wel, N. N., Kovačević, I., Hordijk, P. L., Loregger, A., Huveneers, S. & Zelcer, N., 4 Aug 2020, In: Cell reports. 32, 5, 107944.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  14 Citations (Scopus)
• 2019

  Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis

  Tan, J. M. E., Cook, E. C. L., van den Berg, M., Scheij, S., Zelcer, N. & Loregger, A., 2019, In: Atherosclerosis. 281, p. 137-142

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  29 Citations (Scopus)

• FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB

  Pronk, M. C. A., Majolée, J., Loregger, A., van Bezu, J. S. M., Zelcer, N., Hordijk, P. L. & Kovačević, I., 1 Mar 2019, In: Molecular biology of the cell. 30, 5, p. 607-621 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  12 Citations (Scopus)

• Industrial Trans Fatty Acids Stimulate SREBP2-Mediated Cholesterogenesis and Promote Non-Alcoholic Fatty Liver Disease

  Oteng, A-B., Loregger, A., van Weeghel, M., Zelcer, N. & Kersten, S., 2019, In: Molecular nutrition & food research. 1900385.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  34 Citations (Scopus)

• N-Glycosylation Defects in Humans Lower Low-Density Lipoprotein Cholesterol Through Increased Low-Density Lipoprotein Receptor Expression

  van den Boogert, M. A. W., Larsen, L. E., Ali, L., Kuil, S. D., Chong, P. L. W., Loregger, A., Kroon, J., Schnitzler, J. G., Schimmel, A. W. M., Peter, J., Levels, J. H. M., Steenbergen, G., Morava, E., Dallinga-Thie, G. M., Wevers, R. A., Kuivenhoven, J. A., Hand, N. J., Zelcer, N., Rader, D. J., Stroes, E. S. G., & 2 othersLefeber, D. J. & Holleboom, A. G., 2019, In: Circulation. 140, 4, p. 280-292

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  24 Citations (Scopus)

• The E3 ubiquitin ligase inducible degrader of the LDL receptor/myosin light chain interacting protein in health and disease

  van Loon, N. M., Lindholm, D. & Zelcer, N., 2019, In: Current opinion in lipidology. 30, 3, p. 192-197

  Research output: Contribution to journal › Article › Academic › peer-review
  11 Citations (Scopus)
• 2018

  (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice from Diet-Induced Obesity and Hepatosteatosis

  Ren, L., Sun, Y., Lu, H., Ye, D., Han, L., Wang, N., Daugherty, A., Li, F., Wang, M., Su, F., Tao, W., Sun, J., Zelcer, N., Mullick, A. E., Danser, A. J., Jiang, Y., He, Y., Ruan, X. & Lu, X., 2018, In: Circulation Research. 122, 5, p. 730-741

  Research output: Contribution to journal › Article › Academic › peer-review
  40 Citations (Scopus)

• Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

  van Loon, N. M., Ottenhoff, R., Kooijman, S., Moeton, M., Scheij, S., Roscam Abbing, R. L. P., Gijbels, M. J. J., Levels, J. H. M., Sorrentino, V., Berbée, J. F. P., Rensen, P. C. N. & Zelcer, N., 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 8, p. 1785-1795

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

  Koenis, D. S., Medzikovic, L., van Loenen, P. B., van Weeghel, M., Huveneers, S., Vos, M., Evers-van Gogh, I. J., Van den Bossche, J., Speijer, D., Kim, Y., Wessels, L., Zelcer, N., Zwart, W., Kalkhoven, E. & de Vries, C. J., 21 Aug 2018, In: Cell reports. 24, 8, p. 2127-2140.e7

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  95 Citations (Scopus)
• 2017

  Assaying Low-Density-Lipoprotein (LDL) Uptake into Cells

  Loregger, A., Nelson, J. K. & Zelcer, N., 2017, In: Methods in molecular biology (Clifton, N.J.). 1583, p. 53-63

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)

• EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux

  Nelson, J. K., Koenis, D. S., Scheij, S., Cook, E. C. L., Moeton, M., Santos, A., Lobaccaro, J-M. A., Baron, S. & Zelcer, N., 2017, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 3, p. 423-432

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis

  Loregger, A., Raaben, M., Tan, J., Scheij, S., Moeton, M., van den Berg, M., Gelberg-Etel, H., Stickel, E., Roitelman, J., Brummelkamp, T. & Zelcer, N., 2017, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 11, p. 2064-2074

  Research output: Contribution to journal › Article › Academic › peer-review
  25 Citations (Scopus)

• Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

  Cook, E. C. L., Nelson, J. K., Sorrentino, V., Koenis, D., Moeton, M., Scheij, S., Ottenhoff, R., Bleijlevens, B., Loregger, A. & Zelcer, N., 2017, In: PLoS ONE. 12, 2, e0172721.

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer

  Alioui, A., Dufour, J., Leoni, V., Loregger, A., Moeton, M., Iuliano, L., Zerbinati, C., Septier, A., Val, P., Fouache, A., Russo, V., Volle, D. H., Lobaccaro, J-M. A., Zelcer, N. & Baron, S., 2017, In: Nature communications. 8, 1, 445.

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)

• LRSAM1-mediated ubiquitylation is disrupted in axonal Charcot-Marie-Tooth disease 2P

  Hakonen, J. E., Sorrentino, V., Avagliano Trezza, R., de Wissel, M. B., van den Berg, M., Bleijlevens, B., van Ruissen, F., Distel, B., Baas, F., Zelcer, N. & Weterman, M. A. J., 2017, In: Human Molecular Genetics. 26, 11, p. 2034-2041

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)
• 2016

  A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity

  Tol, M. J., Ottenhoff, R., van Eijk, M., Zelcer, N., Aten, J., Houten, S. M., Geerts, D., van Roomen, C., Bierlaagh, M. C., Scheij, S., Hoeksema, M. A., Aerts, J. M., Bogan, J. S., Dorn, G. W., Argmann, C. A. & Verhoeven, A. J., 2016, In: Diabetes. 65, 9, p. 2591-2605

  Research output: Contribution to journal › Article › Academic › peer-review
  40 Citations (Scopus)

• Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

  Nelson, J. K., Cook, E. C. L., Loregger, A., Hoeksema, M. A., Scheij, S., Kovacevic, I., Hordijk, P. L., Ovaa, H. & Zelcer, N., 26 Feb 2016, In: Journal of Biological Chemistry. 291, 9, p. 4813-4825 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  17 Citations (Scopus)

• Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism

  Lu, X., Meima, M. E., Nelson, J. K., Sorrentino, V., Loregger, A., Scheij, S., Dekkers, D. H. W., Mulder, M. T., Demmers, J. A. A., M-Dallinga-Thie, G., Zelcer, N. & Danser, A. H. J., 2016, In: Circulation Research. 118, 2, p. 222-229

  Research output: Contribution to journal › Article › Academic › peer-review
  35 Citations (Scopus)

• The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL

  Nelson, J. K., Sorrentino, V., Avagliano Trezza, R., Heride, C., Urbe, S., Distel, B. & Zelcer, N., 2016, In: Circulation Research. 118, 3, p. 410-419

  Research output: Contribution to journal › Article › Academic › peer-review
  37 Citations (Scopus)
• 2015

  A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes

  Loregger, A., Cook, E. C. L., Nelson, J. K., Moeton, M., Sharpe, L. J., Engberg, S., Karimova, M., Lambert, G., Brown, A. J. & Zelcer, N., 2015, In: Molecular and Cellular Biology. 36, 2, p. 285-294

  Research output: Contribution to journal › Article › Academic › peer-review
  34 Citations (Scopus)

• Enolase is regulated by Liver X Receptors

  de Boussac, H., Maqdasy, S., Trousson, A., Zelcer, N., Volle, D. H., Lobaccaro, J-M. A. & Baron, S., 2015, In: Steroids. 99, Part B, p. 266-271

  Research output: Contribution to journal › Article › Academic › peer-review
  3 Citations (Scopus)

• LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis

  Kurakula, K., Sommer, D., Sokolovic, M., Moerland, P. D., Scheij, S., van Loenen, P. B., Koenis, D. S., Zelcer, N., van Tiel, C. M. & de Vries, C. J. M., 2015, In: Molecular and Cellular Biology. 35, 1, p. 52-62 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)
• 2014

  Impaired trafficking of the very low density lipoprotein receptor caused by missense mutations associated with dysequilibrium syndrome

  Kizhakkedath, P., Loregger, A., John, A., Bleijlevens, B., Al-Blooshi, A. S., Al-Hosani, A. H., Al-Nuaimi, A. M., Al-Gazali, L., Zelcer, N. & Ali, B. R., 2014, In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1843, 12, p. 2871-2877

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)

• Mutations in STAP1 are associated with autosomal dominant hypercholesterolemia

  Fouchier, S. W., Dallinga-Thie, G. M., Meijers, J. C. M., Zelcer, N., Kastelein, J. J. P., Defesche, J. C. & Hovingh, G. K., 2014, In: Circulation Research. 115, 6, p. 552-555

  Research output: Contribution to journal › Article › Academic › peer-review
  138 Citations (Scopus)

• Myelin alters the inflammatory phenotype of macrophages by activating PPARs

  Bogie, J. F. J., Jorissen, W., Mailleux, J., Nijland, P. G., Zelcer, N., Vanmierlo, T., Van Horssen, J., Stinissen, P., Hellings, N. & Hendriks, J. J. A., 27 Jan 2014, In: Acta Neuropathologica Communications. 2, 1, p. 43-(13 p.) 43.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  63 Citations (Scopus)

• The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway

  Zelcer, N., Sharpe, L. J., Loregger, A., Kristiana, I., Cook, E. C. L., Phan, L., Stevenson, J. & Brown, A. J., 2014, In: Molecular and Cellular Biology. 34, 7, p. 1262-1270

  Research output: Contribution to journal › Article › Academic › peer-review
  116 Citations (Scopus)
• 2013

  Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein

  Sorrentino, V., Fouchier, S. W., Motazacker, M. M., Nelson, J. K., Defesche, J. C., Dallinga-Thie, G. M., Kastelein, J. J. P., Kees Hovingh, G. & Zelcer, N., 2013, In: European Heart journal. 34, 17, p. 1292-1297

  Research output: Contribution to journal › Article › Academic › peer-review
  48 Citations (Scopus)

• NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

  Pietiäinen, V., Vassilev, B., Blom, T., Wang, W., Nelson, J., Bittman, R., Bäck, N., Zelcer, N. & Ikonen, E., 2013, In: Journal of Cell Science. 126, Part 17, p. 3961-3971

  Research output: Contribution to journal › Article › Academic › peer-review
  63 Citations (Scopus)

• The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

  Sorrentino, V., Nelson, J. K., Maspero, E., Marques, A. R. A., Scheer, L., Polo, S. & Zelcer, N., 2013, In: Journal of Lipid Research. 54, 8, p. 2174-2184

  Research output: Contribution to journal › Article › Academic › peer-review
  57 Citations (Scopus)
• 2012

  Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia

  Motazacker, M. M., Pirruccello, J., Huijgen, R., Do, R., Gabriel, S., Peter, J., Kuivenhoven, J. A., Defesche, J. C., Kastelein, J. J. P., Hovingh, G. K., Zelcer, N., Kathiresan, S. & Fouchier, S. W., 2012, In: European Heart journal. 33, 11, p. 1360-1366

  Research output: Contribution to journal › Article › Academic › peer-review
  70 Citations (Scopus)

• A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy

  Weterman, M. A. J., Sorrentino, V., Kasher, P. R., Jakobs, M. E., van Engelen, B. G. M., Fluiter, K., de Wissel, M. B., Sizarov, A., Nürnberg, G., Nürnberg, P., Zelcer, N., Schelhaas, H. J. & Baas, F., 2012, In: Human Molecular Genetics. 21, 2, p. 358-370

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)

• Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)

  Do, H. T., Tselykh, T. V., Mäkelä, J., Ho, T. H., Olkkonen, V. M., Bornhauser, B. C., Korhonen, L., Zelcer, N. & Lindholm, D., 2012, In: Journal of Biological Chemistry. 287, 16, p. 12602-12611

  Research output: Contribution to journal › Article › Academic › peer-review
  58 Citations (Scopus)
• 2011

  Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL)

  Sorrentino, V., Scheer, L., Santos, A., Reits, E., Bleijlevens, B. & Zelcer, N., 2011, In: Journal of Biological Chemistry. 286, 34, p. 30190-30199

  Research output: Contribution to journal › Article › Academic › peer-review
  42 Citations (Scopus)

• Targeted disruption of the Idol gene alters cellular regulation of the LDLR by sterols and LXR agonists

  Scotti, E., Hong, C., Yoshinaga, Y., Tu, Y., Hu, Y., Zelcer, N., Boyadjian, R., de Jong, P. J., Young, S. G., Fong, L. G. & Tontonoz, P., 2011, In: Molecular and Cellular Biology. 31, 9, p. 1885-1893

  Research output: Contribution to journal › Article › Academic › peer-review
  66 Citations (Scopus)

• The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans

  Weissglas-Volkov, D., Calkin, A. C., Tusie-Luna, T., Sinsheimer, J. S., Zelcer, N., Riba, L., Tino, A. M. V., Ordoñez-Sánchez, M. L., Cruz-Bautista, I., Aguilar-Salinas, C. A., Tontonoz, P. & Pajukanta, P., 2011, In: Journal of clinical investigation. 121, 8, p. 3062-3071

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)
• 2010

  The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

  Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Sorrentino, V., Boyadjian, R., Rodenburg, K. C. W., Foley, E., Korhonen, L., Lindholm, D., Nimpf, J., van Berkel, T. J. C., Tontonoz, P. & Zelcer, N., 2010, In: Journal of Biological Chemistry. 285, 26, p. 19720-19726

  Research output: Contribution to journal › Article › Academic › peer-review
  113 Citations (Scopus)
• 2009

  Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR

  A-Gonzalez, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J., Ramirez, C., Díaz, M., Gallardo, G., de Galarreta, C. R., Salazar, J., Lopez, F., Edwards, P., Parks, J., Andujar, M., Tontonoz, P. & Castrillo, A., 2009, In: Immunity. 31, 2, p. 245-258

  Research output: Contribution to journal › Article › Academic › peer-review
  532 Citations (Scopus)