Projects per year
Personal profile
specialisation
Research interests
Situated at the Clinical Genetics department of the Amsterdam Medical Center (NL), Dr Henneman (PI) is leading a research group studying epigenetics of complex and non-complex diseases in order to detect novel associated genetic and epigenetic loci. Moreover, Dr. Henneman is closely involved in follow-up translational studies of novel detected loci. Three major topics are in particular Dr. Henneman’s interest: (1) Early developmental environmental factors and their epigenetic contribution to complex diseases e.g. food allergy, Type II diabetes mellitus and stress disorders like post-traumatic stress disorder (PTSD). (2) Epigenetics in intervention and translational studies focusing on e.g. PTSD and Crohn’s disease. (3) Clinical diagnostic applications of epigenetic signatures in rare syndromes. In relation to the latter, Dr. Henneman is affiliated to the dept. of clinical genetics, genome diagnostics, where he is closely involved in the implementation and application of DNA-methylation signatures of rare syndromes under the flag of EpiSign, an international collaboration with Canadian (London Health Sciences Centre, Canada, Episign, Dr. Bekim Sadokovic) and USA partners. In total Dr. Henneman’ s research group involves 9 PhD students, 2 bioinformaticians and 1 Post doc researcher. In 2017 his first PhD student defended her thesis on complex traits and epigenetic analyses within a large cohort of Ghanaian migrants (promotor Prof. dr. Charles Agyemang). In 2018 Dr. Henneman received substantial funding (in collaboration with Prof. dr, G.R.A.M. D’Haens) from the Helmsley charity foundation (USA) to study therapeutic response of anti-inflammatory therapy in patients suffering from Crohn’s disease in order to develop a personalized treatment protocol. Within this project, Dr. Henneman’ s group also applied single cell technology in this cohort in order to study the context and origin of the detected differential DNA-methylation profiles (unpublished).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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Mannens M.M.A.M.: Clinical Molecular Genetics with emphasis on cardiogenetics and growth malformations
Ensink, J., Krzyzewska, I., Li Yim, A., Mannens, M., Alders, M., Bikker, H., Henneman, P., van Koningsbruggen, S., Lekanne Dit Deprez, R., Lombardi, P., Mook, O., Motazacker, M. & Redeker, B.
1/02/2007 → …
Project: Research
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EPIC-CD
Li Yim, A., Hageman, I., Joustra, V., Satsangi, J., Henneman, P., de Jonge, W. & D' Haens, G.
1/01/2019 → 1/01/2023
Project: Research
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EPIMAC: The next generation epigenetic medicine for inflammation
Li Yim, A., Chen, H., Ghiboub, M., Luque Martin, R., Loring, S., Elfiky, A., Henneman, P., de Jonge, W., de Winther, M. & Prinjha, R. K.
1/01/2015 → 30/06/2019
Project: Research
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Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite-instable colorectal cancers
van Toledo, D. E. FW. M., Bleijenberg, A. G. C., Venema, A., de Wit, M. J., van Eeden, S., Meijer, G. A., Carvalho, B., Dekker, E., Henneman, P., IJspeert, J. E. G. & van Noesel, C. J. M., 1 Mar 2024, In: journal of pathology. Clinical research. 10, 2, e348.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Diagnostic utility and reporting recommendations for clinical DNA methylation episignature testing in genetically undiagnosed rare diseases
Kerkhof, J., Rastin, C., Levy, M. A., Relator, R., McConkey, H., Demain, L., Dominguez-Garrido, E., Kaat, L. D., Houge, S. D., DuPont, B. R., Fee, T., Fletcher, R. S., Gokhale, D., Haukanes, B. I., Henneman, P., Hilton, S., Hilton, B. A., Jenkinson, S., Lee, J. A., Louie, R. J., & 15 others , 1 May 2024, In: Genetics in medicine. 26, 5, 101075.Research output: Contribution to journal › Article › Academic › peer-review
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DNA methylation episignature, extension of the clinical features, and comparative epigenomic profiling of Hao-Fountain syndrome caused by variants in USP7
van der Laan, L., Karimi, K., Rooney, K., Lauffer, P., McConkey, H., Caro, P., Relator, R., Levy, M. A., Bhai, P., Mignot, C., Keren, B., Briuglia, S., Sobering, A. K., Li, D., Vissers, L. E. L. M., Dingemans, A. J. M., Valenzuela, I., Verberne, E. A., Misra-Isrie, M., Zwijnenburg, P. J. G., & 8 others , 1 Mar 2024, In: Genetics in medicine. 26, 3, 101050.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
DNA methylation episignature and comparative epigenomic profiling of HNRNPU-related neurodevelopmental disorder
Rooney, K., van der Laan, L., Trajkova, S., Haghshenas, S., Relator, R., Lauffer, P., Vos, N., Levy, M. A., Brunetti-Pierri, N., Terrone, G., Mignot, C., Keren, B., de Villemeur, T. B., Volker-Touw, C. M. L., Verbeek, N., van der Smagt, J. J., Oegema, R., Brusco, A., Ferrero, G. B., Misra-Isrie, M., & 6 others , 1 Aug 2023, In: Genetics in medicine. 25, 8, 100871.Research output: Contribution to journal › Article › Academic › peer-review
3 Citations (Scopus) -
Epigenome-wide association study of plasma lipids in West Africans: the RODAM study
van der Linden, E. L., Meeks, K. A. C., Chilunga, F., Hayfron-Benjamin, C., Bahendeka, S., Klipstein-Grobusch, K., Venema, A., van den Born, B-J., Agyemang, C., Henneman, P. & Adeyemo, A., 1 Mar 2023, In: eBioMedicine. 89, 104469.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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Additional file 11: Table S4. of Peripheral blood methylation profiling of female Crohn’s disease patients
Li Yim, A. (Contributor), Duijvis, N. W. (Creator), Zhao, J. (Creator), de Jonge, W. (Contributor), D' Haens, G. (Creator), Mannens, M. (Creator), Mul, A. N. P. M. (Creator), te Velde, A. (Contributor), Henneman, P. (Creator), D' Haens, G. (Creator) & Mannens, M. (Creator), Figshare, 2016
DOI: 10.6084/m9.figshare.c.3620078_d2, https://springernature.figshare.com/articles/dataset/Additional_file_11_Table_S4_of_Peripheral_blood_methylation_profiling_of_female_Crohn_s_disease_patients/4391135
Dataset
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MOESM1 of A genome-wide DNA methylation signature for SETD1B-related syndrome
Krzyzewska, I. (Contributor), Maas, S. (Contributor), Henneman, P. (Contributor), Lip, K. V. D. (Contributor), Venema, A. (Contributor), Baranano, K. (Contributor), Chassevent, A. (Contributor), Aref-Eshghi, E. (Contributor), Fukuda, T. (Contributor), Ikeda, H. (Contributor), Jacquemont, M. (Contributor), Kim, H. (Contributor), Labalme, A. (Contributor), Lewis, S. M. E. (Contributor), Lesca, G. (Contributor), Madrigal, I. (Contributor), Mahida, S. (Contributor), Matsumoto, N. (Contributor), Rabionet, R. (Contributor), Rajcan-Separovic, E. (Contributor), Qiao, Y. (Contributor), Sadikovic, B. (Contributor), Saitsu, H. (Contributor), Sweetser, D. A. (Contributor), Alders, M. (Contributor) & Mannens, M. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10252070, https://springernature.figshare.com/articles/MOESM1_of_A_genome-wide_DNA_methylation_signature_for_SETD1B-related_syndrome/10252070
Dataset
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Supplementary table 7. Investigating DNA Methylation as the link between migration and the major non-communicable diseases. The RODAM study
Chilunga, F. (Creator), Henneman, P. (Creator), Venema, A. (Creator), Meeks, K. A. (Creator), Gonzalez, J. R. (Creator), Ruiz-Arenas, C. (Creator), Requena-Méndez, A. (Creator), Beune, E. (Creator), Spranger, J. (Creator), Smeeth, L. (Creator), Bahendeka, S. (Creator), Owusu-Dabo, E. (Creator), Klipstein-Grobusch, K. (Creator), Adeyemo, A. (Contributor), Mannens, M. (Creator) & Agyemang, C. (Creator), Future Science Group, 2021
DOI: 10.25402/epi.14473275, https://future-science-group.figshare.com/articles/dataset/Supplementary_table_7_Investigating_DNA_Methylation_as_the_link_between_migration_and_the_major_non-communicable_diseases_The_RODAM_study/14473275
Dataset
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Supplementary table 6. Investigating DNA Methylation as the link between migration and the major non-communicable diseases. The RODAM study
Chilunga, F. (Creator), Henneman, P. (Creator), Venema, A. (Creator), Meeks, K. A. (Creator), Gonzalez, J. R. (Creator), Ruiz-Arenas, C. (Creator), Requena-Méndez, A. (Creator), Beune, E. (Creator), Spranger, J. (Creator), Smeeth, L. (Creator), Bahendeka, S. (Creator), Owusu-Dabo, E. (Creator), Klipstein-Grobusch, K. (Creator), Adeyemo, A. (Contributor), Mannens, M. (Creator) & Agyemang, C. (Creator), Future Science Group, 2021
DOI: 10.25402/epi.14473272.v1, https://future-science-group.figshare.com/articles/dataset/Supplementary_table_6_Investigating_DNA_Methylation_as_the_link_between_migration_and_the_major_non-communicable_diseases_The_RODAM_study/14473272/1
Dataset
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Supplementary table 8. Investigating DNA methylation as the link between migration and the major non-communicable diseases. The RODAM study
Chilunga, F. (Creator), Henneman, P. (Creator), Venema, A. (Creator), Meeks, K. A. (Creator), Gonzalez, J. R. (Creator), Ruiz-Arenas, C. (Creator), Requena-Méndez, A. (Creator), Beune, E. (Creator), Spranger, J. (Creator), Smeeth, L. (Creator), Bahendeka, S. (Creator), Owusu-Dabo, E. (Creator), Klipstein-Grobusch, K. (Creator), Adeyemo, A. (Contributor), Mannens, M. (Creator) & Agyemang, C. (Creator), Future Science Group, 2021
DOI: 10.25402/epi.14473281.v1, https://future-science-group.figshare.com/articles/dataset/Supplementary_table_8_Investigating_DNA_methylation_as_the_link_between_migration_and_the_major_non-communicable_diseases_The_RODAM_study/14473281/1
Dataset