Peter Hordijk

Research output

Research output per year 1990 2003 2004 2006 2007 2008 2009 2010 2012 2013 2016 2017 2018 2019 2020 2021 2023

• 141 Article
• 15 Review article
• 4 Comment/Letter to the editor
• 4 Short survey
• 8 More
  • 3 Meeting Abstract
  • 2 Editorial
  • 1 Inaugural speech
  • 1 Chapter
  • 1 Erratum/Corrigendum

Research output per year

Research output per year

Search results

• 2023

  Differential role for rapid proteostasis in Rho GTPase-mediated control of quiescent endothelial integrity

  Podieh, F., Wensveen, R., Overboom, M. C., Abbas, L., Majolée, J. & Hordijk, P. L., 1 Apr 2023, In: Journal of Biological Chemistry. 299, 4, 104593.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Extravasation of biodegradable microspheres in the rat brain

  van der Wijk, A-E., Georgakopoulou, T., Steendam, R., Zuidema, J., Hordijk, P. L., Bakker, E. N. T. P. & van Bavel, E., 1 Dec 2023, In: Drug Delivery. 30, 1, p. 2194579 1 p., 2194579.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• The effect of circulating iron on barrier integrity of primary human endothelial cells

  Madsen, M. C., Podieh, F., Overboom, M. C., Thijs, A., den Heijer, M. & Hordijk, P. L., 1 Dec 2023, In: Scientific reports. 13, 1, 16857.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension

  Manz, X. D., Szulcek, R., Pan, X., Symersky, P., Dickhoff, C., Majolée, J., Kremer, V., Michielon, E., Jordanova, E. S., Radonic, T., Bijnsdorp, I. V., Piersma, S. R., Pham, T. V., Jimenez, C. R., Noordegraaf, A. V., de Man, F. S., Boon, R. A., Voorberg, J., Hordijk, P. L., Aman, J., & 1 othersBogaard, H. J., 1 Apr 2022, In: American journal of respiratory and critical care medicine. 205, 7, p. 808-818 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  22 Citations (Scopus)
• 2021

  Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation

  Amado-Azevedo, J., van Stalborch, A-M. D., Valent, E. T., Nawaz, K., van Bezu, J., Eringa, E. C., Hoevenaars, F. P. M., de Cuyper, I. M., Hordijk, P. L., van Hinsbergh, V. W. M., van Nieuw Amerongen, G. P., Aman, J. & Margadant, C., Aug 2021, In: Angiogenesis. 24, 3, p. 677-693 17 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  16 Citations (Scopus)

• Electrostatic forces mediate the specificity of RHO GTPase-GDI interactions

  Mosaddeghzadeh, N., Kazemein Jasemi, N. S., Majolée, J., Zhang, S-C., Hordijk, P. L., Dvorsky, R. & Ahmadian, M. R., 1 Nov 2021, In: International journal of molecular sciences. 22, 22, 12493.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells

  Reinhard, N. R., Van Der Niet, S., Chertkova, A., Postma, M., Hordijk, P. L., Gadella, T. W. J., Goedhart, J. & Gadella Jr, T. W. J., 2021, In: Small GTPases. 12, 3, p. 226-240 15 p., DOI: 10.1080/21541248.2019.1658509.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Patient-Specific 3-Dimensional Model of Smooth Muscle Cell and Extracellular Matrix Dysfunction for the Study of Aortic Aneurysms

  Bogunovic, N., Meekel, J. P., Majolée, J., Hekhuis, M., Pyszkowski, J., Jockenhövel, S., Kruse, M., Riesebos, E., Micha, D., Blankensteijn, J. D., Hordijk, P. L., Ghazanfari, S. & Yeung, K. K., Aug 2021, In: Journal of endovascular therapy. 28, 4, p. 604-613 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass

  Dekker, N. A. M., van Leeuwen, A. L. I., van Meurs, M., Moser, J., Pankras, J. E., van der Wel, N. N., Niessen, H. W., Vervloet, M. G., Vonk, A. B. A., Hordijk, P. L., Boer, C. & van den Brom, C. E., 1 Dec 2021, In: Intensive Care Medicine Experimental. 9, 1, p. 30 30.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading

  Majolée, J., Podieh, F., Hordijk, P. L. & Kovačević, I., 1 Jul 2021, In: PLOS ONE. 16, 7 July, e0254386.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  12 Citations (Scopus)
• 2020

  Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity

  Botros, L., Pronk, M. C. A., Juschten, J., Liddle, J., Morsing, S. K. H., van Buul, J. D., Bates, R. H., Tuinman, P. R., van Bezu, J. S. M., Huveneers, S., Bogaard, H. J., van Hinsbergh, V. W. M., Hordijk, P. L. & Aman, J., 14 May 2020, In: Journal of Cell Science. 133, 9, jcs240077.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• In vitro endothelial hyperpermeability occurs early following traumatic hemorrhagic shock

  van Leeuwen, A. L. I., Naumann, D. N., Dekker, N. A. M., Hordijk, P. L., Hutchings, S. D., Boer, C. & van den Brom, C. E., 2020, In: Clinical Hemorheology and Microcirculation. 75, 2, p. 121-133 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

  van der Wijk, A. E., Georgakopoulou, T., Majolée, J., van Bezu, J. S. M., van der Stoel, M. M., van het Hof, B. J., de Vries, H. E., Huveneers, S., Hordijk, P. L., Bakker, E. N. T. P. & van Bavel, E., 1 Dec 2020, In: Acta Neuropathologica Communications. 8, 1, 195.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Most exposed: the endothelium in chronic kidney disease

  Vila Cuenca, M., Hordijk, P. L. & Vervloet, M. G., 1 Sept 2020, In: Nephrology, dialysis, transplantation. 35, 9, p. 1478-1487 10 p., gfz055.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  29 Citations (Scopus)

• The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

  Tan, J. M. E., van der Stoel, M. M., van den Berg, M., van Loon, N. M., Moeton, M., Scholl, E., van der Wel, N. N., Kovačević, I., Hordijk, P. L., Loregger, A., Huveneers, S. & Zelcer, N., 4 Aug 2020, In: Cell reports. 32, 5, 107944.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  14 Citations (Scopus)
• 2019

  CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity

  Majolée, J., Pronk, M. C. A., Jim, K. K., van Bezu, J. S. M., van der Sar, A. M., Hordijk, P. L. & Kovačević, I., 1 Dec 2019, In: Scientific reports. 9, 1, 8131.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  15 Citations (Scopus)

• DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes

  Noll, B., Benz, D., Frey, Y., Meyer, F., Lauinger, M., Eisler, S. A., Schmid, S., Hordijk, P. L. & Olayioye, M. A., 2019, In: Journal of Cell Science. 132, 11, jcs223172.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts

  van der Wijk, A-E., Lachkar, N., de Vos, J., Grootemaat, A. E., van der Wel, N. N., Hordijk, P. L., Bakker, E. N. T. P. & vanBavel, E., 1 Jan 2019, In: Stroke. 50, 6, p. 1590-1594

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB

  Pronk, M. C. A., Majolée, J., Loregger, A., van Bezu, J. S. M., Zelcer, N., Hordijk, P. L. & Kovačević, I., 1 Mar 2019, In: Molecular biology of the cell. 30, 5, p. 607-621 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  12 Citations (Scopus)

• Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology

  Bogunovic, N., Meekel, J. P., Micha, D., Blankensteijn, J. D., Hordijk, P. L. & Yeung, K. K., 1 Dec 2019, In: Scientific reports. 9, 1, 6837.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  42 Citations (Scopus)

• Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels

  Dekker, N. A. M., van Leeuwen, A. L. I., van Strien, W. W. J., Majolée, J., Szulcek, R., Vonk, A. B. A., Hordijk, P. L., Boer, C. & van den Brom, C. E., 11 Apr 2019, In: Critical Care. 23, 1, 117.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  22 Citations (Scopus)

• Stabilization of cell-cell junctions by active Vitamin D ameliorates uraemia-induced loss of human endothelial barrier function

  Cuenca, M. V., van Bezu, J., Beelen, R. H. J., Vervloet, M. G. & Hordijk, P. L., 1 Feb 2019, In: Nephrology, dialysis, transplantation. 34, 2, p. 252-264 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  26 Citations (Scopus)
• 2018

  A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability

  Amado-Azevedo, J., de Menezes, R. X., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 2018, In: PLoS ONE. 13, 7, e0201231.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study

  Bokslag, A., Franssen, C., Alma, L. J., Kovacevic, I., van Kesteren, F., Teunissen, P. W., Kamp, O., Ganzevoort, W., Hordijk, P. L., de Groot, C. J. M. & Paulus, W. J., 2018, In: PLOS ONE. 13, 6, e0198908.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  33 Citations (Scopus)

• Endothelial dysfunction as a long-term effect of late onset hypertensive pregnancy disorders: High BMI is key

  Alma, L. J., de Groot, C. J. M., de Menezes, R. X., Hermes, W., Hordijk, P. L., Kovačević, I. & Kovacevic, I., 2018, In: European journal of obstetrics, gynecology, and reproductive biology. 225, p. 62-69

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  12 Citations (Scopus)

• Inflammation-sensitive myosin-x functionally supports leukocyte extravasation by Cdc42-mediated ICAM-1-rich endothelial filopodia formation

  Kroon, J., Schaefer, A., van Rijssel, J., Hoogenboezem, M., van Alphen, F., Hordijk, P., Stroes, E. S. G., Strömblad, S., van Rheenen, J. & van Buul, J. D., 2018, In: Journal of Immunology. 200, 5, p. 1790-1801 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  25 Citations (Scopus)

• The covalently immobilized antimicrobial peptide LL37 acts as a VEGF mimic and stimulates endothelial cell proliferation

  Szulcek, R., Bollensdorff, C., Hordijk, P. & Gabriel, M., 2018, In: Biochemical and Biophysical Research Communications. 496, 3, p. 887-890

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

  Kovačević, I., Sakaue, T., Majoleé, J., Pronk, M. C., Maekawa, M., Geerts, D., Fernandez-Borja, M., Higashiyama, S. & Hordijk, P. L., 5 Mar 2018, In: Journal of cell biology. 217, 3, p. 1015-1032 18 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  38 Citations (Scopus)

• The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity

  Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 1 Feb 2018, In: Vascular Pharmacology. 101, p. 38-47 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  13 Citations (Scopus)

• Vitamin D attenuates endothelial dysfunction in uremic rats and maintains human endothelial stability

  Cuenca, M. V., Ferrantelli, E., Meinster, E., Pouw, S. M., Kovačević, I., de Menezes, R. X., Niessen, H. W., Beelen, R. H. J., Hordijk, P. L. & Vervloet, M. G., 1 Sept 2018, In: Journal of the American Heart Association. 7, 17, e008776.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  22 Citations (Scopus)
• 2017

  A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity

  Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., Menezes, R. X., Van Beusechem, V. W., Van Nieuw Amerongen, G. P., Van Hinsbergh, V. W. M. & Hordijk, P. L., 1 Dec 2017, In: Scientific reports. 7, 1, 10132.

  Research output: Contribution to journal › Article › Academic › peer-review
  19 Citations (Scopus)

• Endothelial CD2AP binds the receptor ICAM-1 to control mechanosignaling, leukocyte adhesion, and the route of leukocyte diapedesis in vitro

  Schaefer, A., Van Duijn, T. J., Majolee, J., Burridge, K. & Hordijk, P. L., 15 Jun 2017, In: Journal of Immunology. 198, 12, p. 4823-4836 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor

  Smeets, M. W. J., Bierings, R., Meems, H., Mul, F. P. J., Geerts, D., Vlaar, A. P. J., Voorberg, J. & Hordijk, P. L., 1 Mar 2017, In: PLoS ONE. 12, 3, p. e0173077 e0173077.

  Research output: Contribution to journal › Article › Academic › peer-review
  13 Citations (Scopus)

• RhoA, RhoB and RhoC differentially regulate endothelial barrier function

  Pronk, M. C. A., van Bezu, J. S. M., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 26 Sept 2017, In: Small GTPases. 10, 6, p. 1-19 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  38 Citations (Scopus)

• Stasis Promotes Erythrocyte Adhesion to von Willebrand Factor

  Smeets, M. W. J., Mourik, M. J., Niessen, H. W. M. & Hordijk, P. L., Sept 2017, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 9, p. 1618-1627 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  36 Citations (Scopus)

• The balance between Gα_i-Cdc42/Rac and Gα_12/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate

  Reinhard, N. R., Mastop, M., Yin, T., Wu, Y., Bosma, E. K., Gadella, T. W. J., Goedhart, J. & Hordijk, P. L., 7 Nov 2017, In: Molecular biology of the cell. 28, 23, p. 3371-3382 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  46 Citations (Scopus)
• 2016

  A New Generation of FRET Sensors for Robust Measurement of Gα_i1, Gα_i2 and Gα_i3 Activation Kinetics in Single Cells

  van Unen, J., Stumpf, A. D., Schmid, B., Reinhard, N. R., Hordijk, P. L., Hoffmann, C., Gadella (jr.), T. W. J., Goedhart, J. & Gadella, T. W. J., 22 Jan 2016, In: PLOS ONE. 11, 1, p. e0146789 14 p., e0146789.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  41 Citations (Scopus)

• Correction: Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

  Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., Van Nieuw Amerongen, G. P., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 15 Nov 2016, In: PLOS ONE. 11, 11, p. e0166809 e0157233.

  Research output: Contribution to journal › Article › Academic › peer-review
  46 Citations (Scopus)

• Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

  Nelson, J. K., Cook, E. C. L., Loregger, A., Hoeksema, M. A., Scheij, S., Kovacevic, I., Hordijk, P. L., Ovaa, H. & Zelcer, N., 26 Feb 2016, In: Journal of Biological Chemistry. 291, 9, p. 4813-4825 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  17 Citations (Scopus)

• ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia

  Woodfin, A., Beyrau, M., Voisin, M-B., Ma, B., Whiteford, J. R., Hordijk, P. L., Hogg, N. & Nourshargh, S., 18 Feb 2016, In: Blood. 127, 7, p. 898-907

  Research output: Contribution to journal › Article › Academic › peer-review
  87 Citations (Scopus)

• Recent insights into endothelial control of leukocyte extravasation

  Hordijk, P. L., Apr 2016, In: Cellular and molecular life sciences. 73, 8, p. 1591-1608

  Research output: Contribution to journal › Article › Academic › peer-review
  24 Citations (Scopus)

• Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells

  Reinhard, N. R., van Helden, S. F., Anthony, E. C., Yin, T., Wu, Y. I., Goedhart, J., Gadella, T. W. J. & Hordijk, P. L., 5 May 2016, In: Scientific reports. 6, p. 25502 16 p., 25502.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  43 Citations (Scopus)

• The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

  Dorland, Y. L., Malinova, T. S., van Stalborch, A-M. D., Grieve, A. G., van Geemen, D., Jansen, N. S., de Kreuk, B-J., Nawaz, K., Kole, J., Geerts, D., Musters, R. J. P., de Rooij, J., Hordijk, P. L. & Huveneers, S., 15 Jul 2016, In: Nature communications. 7, p. 12210 12210.

  Research output: Contribution to journal › Article › Academic › peer-review
  36 Citations (Scopus)

• Traction force dynamics predict gap formation in activated endothelium

  Valent, E. T., van Nieuw Amerongen, G., van Hinsbergh, V. W. M. & Hordijk, P. L., 10 Sept 2016, In: Experimental cell research. 347, 1, p. 161-170

  Research output: Contribution to journal › Article › Academic › peer-review
  20 Citations (Scopus)
• 2015

  Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration

  Schaefer, A. & Hordijk, P. L., 1 Jan 2015, In: Journal of Cell Science. 128, 13, p. 2221-2230 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  77 Citations (Scopus)

• Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking

  Daniel, A. E., Timmerman, I., Kovacevic, I., Hordijk, P. L., Adriaanse, L., Paatero, I. & Belting, H-G., 1 Dec 2015, In: PLOS ONE. 10, 12, p. e0145684 e0145684.

  Research output: Contribution to journal › Article › Academic › peer-review
  18 Citations (Scopus)
• 2014

  Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration

  Schaefer, A., te Riet, J., Ritz, K., Hoogenboezem, M., Anthony, E. C., Mul, F. P. J., de Vries, C. J., Daemen, M. J., Figdor, C. G. & Hordijk, P. L., 1 Jan 2014, In: Journal of Cell Science. 127, Part 20, p. 4470-4482 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  83 Citations (Scopus)

• F-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries and veins

  van Geemen, D., Smeets, M. W. J., van Stalborch, A-M. D., Woerdeman, L. A. E., Daemen, M. J. A. P., Hordijk, P. L. & Huveneers, S., 1 Jan 2014, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 9, p. 2059-2067 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  43 Citations (Scopus)

• Toward understanding RhoGTPase specificity: structure, function and local activation: Structure, function and local activation

  Schaefer, A., Reinhard, N. R. & Hordijk, P. L., 12 Dec 2014, In: Small GTPases. 5, 2, p. 6-11

  Research output: Contribution to journal › Article › Academic › peer-review
  73 Citations (Scopus)
• 2013

  BIGH3 modulates adhesion and migration of hematopoietic stem and progenitor cells

  Klamer, S. E., Kuijk, C. G. M., Hordijk, P. L., von Lindern, M., van Hennik, P. B. & Voermans, C., 1 Sept 2013, In: Cell adhesion & migration. 7, 5, p. 434-449 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  25 Citations (Scopus)