Projects per year
Phil Barnett joined the group in 2003 as a protein biochemist. He has a wide background of expertise in biochemistry from molecular genetics to the structural characterization of proteins. During his PhD period he focused on both the biochemical and molecular characterization of a HOCl producing enzyme secreted by a fungus–protein purification, enzyme kinetics, cloning and crystal structure of first vnadium containing chloroperoxidase.
Shortly thereafter he started work as a postdoc at the AMC working on the purification, crystallization and mutational/functional analysis of the yeast peroxisomal import proteins Pex5, Pex13 and Pex14. Protein modelling and sequence analysis became a personal and even resulted in a couple of extra publications during this period.
After this period he joined a small starting spin-off company, Chromagenics, of the UvA as senior scientist/post-doc. The group was interested in identifying and isolating chromatin boundary elements and putting them to use in mammalian protein expression systems. He left this position in 2003 to start work at the Department of Anatomy and Embryology.
For better, more up-to-date than WOS, view of published articles and book chapters please check out scholar.google.nl/citations
Current research focusses on the application of genome wide techniques (eg. ChIP-seq, RNAseq, 4C, bioinformatics) aimed at unravelling the regulation of cardiac transcriptome. Application of these techniques to investigate and provide functional information and basis to GWAS (genome wide association study) data. Central hypothesis is driven by the idea that GWAS can be used as a (rough) positional indicator for regulatory sequences. Genetic variation between individuals leads to trait differences, which may be disadvantageous, particularly when accompanied by disease. Understanding these connections (molecularly) may lead to new insights and approaches to patient care.
This postion allows me to exploit my knowledge of both protein biochemistry and higher order gene regulation, whilst at the same time working in a clinically translational environment.
PhD, The Vanadium Chloroperoxidase: Primary structure to function, University of Amsterdam
1 Feb 1993 → 1 Feb 1997
Award Date: 10 Oct 1997
Examiner Ph.D, University of Bristol
Examiner Masters Biomedical Sciences, University of Amsterdam: Faculty of Science (FNWI)
Jul 2017 → …
Collaborations and top research areas from the last five years
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Christoffels V.M.: Transcriptional mechanism controlling of heart pacemaker and conduction system formation
Christoffels, V., Barnett, P., Postma, A., Jensen, B., de Gier - de Vries, C., Wakker, V., van den Boogaard, M., van Duijvenboden, K., van Eif, V., Gunthel, M., Hooijkaas, I., Man, J., Mattiotti, A., Mohan, R., van Ouwerkerk, A., Prakash, S., Scholman, K., Schreuders, C. & van Weerd, H.
1/01/2007 → …
Christoffels, V. M. & Barnett, P., 1 Jan 2023, In: Nature cardiovascular research. 2, 1, p. 10-12 3 p.
Research output: Contribution to journal › Comment/Letter to the editor › Academic
KORA-Study Group, 21 Jan 2022, In: Circulation Research. 130, 2, p. 166-180 15 p.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access9 Citations (Scopus)
Patient-specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunctionvan Ouwerkerk, A. F., Bosada, F. M., van Duijvenboden, K., Houweling, A. C., Scholman, K. T., Wakker, V., Allaart, C. P., Uhm, J-S., Mathijssen, I. B., Baartscheer, T., Postma, A. V., Barnett, P., Verkerk, A. O., Boukens, B. J. & Christoffels, V. M., 22 Feb 2022, In: Circulation. 145, 8, p. 606-619 14 p.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access5 Citations (Scopus)
Epigenetic state changes underlie metabolic switch in mouse post-infarction border zone cardiomyocytesGünthel, M., Duijvenboden, K. V., de Bakker, D. E. M., Hooijkaas, I. B., Bakkers, J., Barnett, P. & Christoffels, V. M., 1 Nov 2021, In: Journal of cardiovascular development and disease. 8, 11, 134.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access3 Citations (Scopus)
Neuregulin-1 enhances cell-cycle activity, delays cardiac fibrosis, and improves cardiac performance in rat pups with right ventricular pressure loadBossers, G. P. L., Günthel, M., van der Feen, D. E., Hagdorn, Q. A. J., Koop, A-M. C., van Duijvenboden, K., Barnett, P., Borgdorff, M. A. J., Christoffels, V. M., Silljé, H. H. W., Berger, R. M. F. & Bartelds, B., 2021, (E-pub ahead of print) In: Journal of Thoracic and Cardiovascular Surgery.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access4 Citations (Scopus)