Projects per year
Personal profile
Research interests
Population pharmacokinetic-pharmacodynamic modeling of antimicrobial drugs to answer the main research question "which individual dose will optimize drug exposure in blood and the site of infection to obtain favorable clinical outcome (cure of infection) with a low likelihood of side effects and risk for acquiring drug resistance".
Collaboration with the Molecular Biology and Microbial Food Safety research group of the Swammerdam Institute for Life Sciences of the University of Amsterdam (Prof. dr. Benno ter Kuile, PhD)
Collaboaration with the departement of Intensive Care Medicine (Prof. dr. J. Wauters) and the departement of Hospital Pharmacy (Prof. dr. I. Spriet) of the University Hospitals Leuven, Belgium
Clinical pharmacological research of clotting factors (prothrombin complex concentrate in patients with an acquired deficiency and factor VIII in heamophilia A patients) to answer the main research question "which dosing strategy will optimize clinical outcome (stop or prevent bleeding) with a low likelihood of side effects (thrombosis)".
Collaboration with the department of Haematology of the University Medical Center Groningen (Prof. dr. K. Meijer and dr. N. Khorsand) and collaboration with the department of Haematology of the Erasmus MC Rotterdam (Dr. M. Kruip)
specialisation
specialisation
Pharmacokinetics/Pharmacodynamics, Pharmacometrics, Antibiotics, Haemophilia, Clinical Pharmacology
Keywords
- RS Pharmacy and materia medica
- RM Therapeutics. Pharmacology
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Mathôt R.A.A.: Population pharmacokinetic-pharmacodynamic research
Achterbergh, R., Berends, S., ten Berg - Lammers, L., Bijleveld, Y., Hodiamont, C., Preijers, T., Wind, C., Mathot, R., Fijnvandraat, K., de Haan, T., Kemper, M., Klümpen, H., van Hest, R., Kuks, P., Zwaan, C. M., Franken, L., Hazendonk, C., Masman, A., van Moort, I., Sassen, S., Schutte, L. M., Cnossen, M., van Gelder, T., Kruip, M. J. H. A., Leebeek, F. W. G. & Tibboel, D.
1/12/2012 → …
Project: Research
Research output
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Peri-operative desmopressin combined with pharmacokinetic-guided factor VIII concentrate in non-severe haemophilia A patients
Romano, L. G. R., Schütte, L. M., van Hest, R. M., Meijer, K., Laros-van Gorkom, B. A. P., Nieuwenhuizen, L., Eikenboom, J., Heubel-Moenen, F. C. J. I., Uitslager, N., Coppens, M., Fijnvandraat, K., Driessens, M. H. E., Polinder, S., Cnossen, M. H., Leebeek, F. W. G., Mathôt, R. A. A. & Kruip, M. J. H. A., Mar 2024, In: Haemophilia. 30, 2, p. 355-366 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Population pharmacokinetics of vancomycin in term neonates with perinatal asphyxia treated with therapeutic hypothermia
PharmaCool Study Group, 7 Mar 2024, (E-pub ahead of print) In: British journal of clinical pharmacology.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
An Unusual Case of Low Vancomycin Exposure Despite Extremely High Vancomycin Doses Accompanied by Renal Toxicity: A Grand Round
van Schip, A. M., van Diemen, J. J. K., van Hest, R. M. & Harris, V. C., 1 Apr 2023, In: Therapeutic drug monitoring. 45, 2, p. 136-139 4 p.Research output: Contribution to journal › Article › Academic › peer-review
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On the potential for discontinuing atovaquone-proguanil (AP) ad-hoc post-exposure and other abbreviated AP-regimens: Pharmacology, pharmacokinetics and perspectives
Schnyder, J. L., de Jong, H. K., Bache, E. B., van Hest, R. M., Schlagenhauf, P., Borrmann, S., Hanscheid, T. & Grobusch, M. P., 1 Mar 2023, In: Travel medicine and infectious disease. 52, p. 102520 102520.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Pharmacokinetic/Pharmacodynamic Target Attainment of Ceftazidime in Adult Patients on General Wards with Different Degrees of Renal Function: A Prospective Observational Bicenter Cohort Study
Zieck, S. E., de Vroom, S. L., Mulder, F. P., van Twillert, G., Mathôt, R. A. A., Geerlings, S. E. & van Hest, R. M., 1 Mar 2023, In: Antibiotics. 12, 3, 469.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Activities
- 2 Editorial activity
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Journal of Antimicrobial Chemotherapy (Journal)
Reinier van Hest (Reviewer)
1 Jan 2019 → 1 Jan 2046Activity: Peer review and Editorial work › Editorial activity
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Therapeutic Drug Monitoring (Journal)
Reinier van Hest (Member of editorial board)
1 Jan 2015 → 1 Jan 2046Activity: Peer review and Editorial work › Editorial activity