Projects per year
My main focus of research is Acute Lung Disease and Injury in Children.
Within this theme I have special interest in acute, severe viral (respiratory syncytial virus, RSV) infections and the effects of (pediatric) intensive care unit treatments such as mechanical ventilation, hyperoxia and fluid therapy. Research studies include clinical studies, translational animal studies (mice, rats, lambs and calves) and laboratory in vitro studies using complex co-cultures with immune (eg, neutrophils) and airway epithelial cells. With this work, I have characterized pneumovirus animal models for severe RSV infections in the last years. Furthermore, I am unraveling the importance of neutrophil extracellular traps in the pathophysiology of airway mucus obstruction.
Within this theme I have successfully initiated and established collaboration with multiple (inter)national partners from the:
- National Institutes of Allergy and Infectious Diseases (NIAID, NIH), Bethesda, MD, USA
- Department of Pulmonary and Critical Care, University of Washington, Seattle, WA, USA
- Bioveterinary Research University of Wageningen, Lelystad, The Netherlands
- Department of Pediatric Infectious Diseases, Wilhelmina Children’s Hospital, Utrecht, The Netherlands
- Department of Pediatric Pulmonology, Children’s Hospital Richmond, VG, USA
- Department of Lung Development and Remodeling, Max Planck Institute, Bad Nauheim, Germany
Other established research lines include:
- Non-invasive ventilation face mask personalization by 3D scanning and printing techniques (in collaboration with Technical medicine from the TU Twente and Industrial Engineers from the TU Delft)
- Aerosols and SARS-CoV-2 transmission (in collaboration with Van der Waals-Zeeman Institute, Institute of Physics, University of Amsterdam)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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3D4children: 3Dbeademingsmaskers voor kinderen
1/05/2022 → 1/03/2025
van Woensel J.B.M.: Acute lung injury in children
Cortjens, B., Ingelse, S. A., van Meenen, D. M. P., van Woensel, J. & Bem, R. A.
1/01/2013 → …
Mucus Rheology ICU
Animal models of human respiratory syncytial virus diseaseBem, R. A., Domachowske, J. B. & Rosenberg, H. F., 2011, In: American journal of physiology. Lung cellular and molecular physiology. 301, 2, p. L148-L156
Research output: Contribution to journal › Review article › Academic › peer-review149 Citations (Scopus)
Life-threatening bronchiolitis in children: eight decades of critical careBem, R. A., Bont, L. J. & van Woensel, J. B. M., Feb 2020, In: lancet. Respiratory medicine. 8, 2, p. 142-144 3 p.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access11 Citations (Scopus)
Small droplet aerosols in poorly ventilated spaces and SARS-CoV-2 transmissionSomsen, G. A., van Rijn, C., Kooij, S., Bem, R. A. & Bonn, D., Jul 2020, In: The Lancet Respiratory Medicine. 8, 7, p. 658-659 2 p.
Research output: Contribution to journal › Comment/Letter to the editor › AcademicOpen Access243 Citations (Scopus)
Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus diseaseCortjens, B., de Boer, O. J., de Jong, R., Antonis, A. F., Sabogal Piñeros, Y. S., Lutter, R., van Woensel, J. B. & Bem, R. A., 2016, In: Journal of pathology. 238, 3, p. 401-411
Research output: Contribution to journal › Article › Academic › peer-review148 Citations (Scopus)
The Local and Systemic Exposure to Oxygen in Children with Severe Bronchiolitis on Invasive Mechanical Ventilation: A Retrospective Cohort StudyLilien, T. A., de Sonnaville, E. S. V., van Woensel, J. B. M. & Bem, R. A., 1 Feb 2023, In: Pediatric Critical Care Medicine. 24, 2, p. E115-E120
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access1 Citation (Scopus)