Research output per year
Research output per year
Personal profile
Research interests
The unifying theme of my research program is the regulation of effector/memory T cell formation in human and mice. The goals are to (1) identify functionally distinct T-cell subsets, (2) study the regulation of their specificity, expansion and effector functions, and (3) define their roles in normal and pathological immune reactions, e.g. (persistent) virus infections, allo-reactivity and immunodeficiency. Detailed knowledge on the regulation and manipulation of T cell immunity is necessary to improve the design of vaccines for infectious and malignant disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Allo-reactive tissue-resident T cells causing damage: An inside job
van Lier, R. A. W. & Hombrink, P., 4 Apr 2022, In: Journal of Experimental Medicine. 219, 4, e20220121.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Hobit and Blimp-1 instruct the differentiation of iNKT cells into resident-phenotype lymphocytes after lineage commitment
Kragten, N. A. M., Taggenbrock, R. L. RE., Parga Vidal, L., van Lier, R. A. W., Stark, R. & van Gisbergen, K. P. JM., Mar 2022, In: European journal of immunology. 52, 3, p. 389-403 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Hobit and Blimp-1 regulate TRM abundance after LCMV infection by suppressing tissue exit pathways of TRMprecursors
Parga-Vidal, L., Taggenbrock, R. L. R. E., Beumer-Chuwonpad, A., Aglmous, H., Kragten, N. A. M., Behr, F. M., Bovens, A. A., van Lier, R. A. W., Stark, R. & van Gisbergen, K. P. J. M., Jul 2022, In: European journal of immunology. 52, 7, p. 1095-1111 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus) -
Single-Cell Transcriptomics Reveals Discrete Steps in Regulatory T Cell Development in the Human Thymus
Morgana, F., Opstelten, R., Slot, M. C., Scott, A. M., van Lier, R. A. W., Blom, B., Mahfouz, A. & Amsen, D., 15 Jan 2022, In: Journal of immunology (Baltimore, Md.. 208, 2, p. 384-395 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus) -
Two sides of the same coin: Protective versus pathogenic CD4+ resident memory T cells
Oja, A. E., van Lier, R. A. W. & Hombrink, P., 8 Apr 2022, In: Science immunology. 7, 70, p. eabf9393 abf9393.Research output: Contribution to journal › Article › Academic › peer-review
11 Citations (Scopus)