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Personal profile

Research interests

My research focuses on identifying the (integrative) omics signature of depression (using DNA, methylation, gene expression, proteomics) and on finding better treatment for, and identification of, depression subtypes, mainly using data from NESDA (The Netherlands Study of Depression and Anxiety) and NTR (The Netherlands Twin Registry).

I am co PI of PERCIM (Personalized Care for Immuno-Metabolic Depression) (https://psychiatryamsterdam.nl/project/percim/) and was part of the BIOS (Biobank-based integrative omics study) consortium management (https://www.bbmri.nl/acquisition-use-analyze/bios). As NESDA, NTR and BIOS we are part of the large eQTL meta analysis: the eQTLGen Consortium (https://www.eqtlgen.org/).

I am teaching a course on human molecular genetics for the research master 'Genes in Behaviour and Health' (https://vuweb.vu.nl/nl/onderwijs/master/genes-in-behaviour-and-health).

For the publication I (co) authored see my google scholar page: https://scholar.google.nl/citations?user=cHJDM0YAAAAJ&hl=en.

And for the publications from the Consortia I participated in see:

BIOS: https://pubmed.ncbi.nlm.nih.gov/?term=BIOS+Consortium%5BCorporate+Author%5D&sort=date.

eQTLGen: https://pubmed.ncbi.nlm.nih.gov/?sort=date&term=eQTLGen+Consortium%5BCorporate+Author%5D.

 
 
See also our conditional eQTL catalog based on NESDA and NTR data:
 
And the Methylation and RNA-seq QTL catalogs from BIOS:
 
Email: ri.jansen at amsterdamumc.nl

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Network

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • Gene expression in major depressive disorder

    Jansen, R., Penninx, B. W. J. H., Madar, V., Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A. T. F., van der Wee, N., Smit, J. H., Brooks, A. I., Tischfield, J., Posthuma, D., Schoevers, R., Grootheest, G., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., Zou, F., & 2 othersSun, W. & Sullivan, P. F., 2016, In: Molecular psychiatry. 21, p. 339-347 347 p.

    Research output: Contribution to JournalArticleAcademicpeer-review

    127 Citations (Scopus)
  • Conditional eQTL analysis reveals allelic heterogeneity of gene expression

    Jansen, R., Hottenga, J-J., Nivard, M. G., Abdellaoui, A., Laport, B., de Geus, E. J., Wright, F. A., Penninx, B. W. J. H. & Boomsma, D. I., 15 Apr 2017, In: Human Molecular Genetics. 26, 8, p. 1444-1451 8 p., ddx043.

    Research output: Contribution to JournalArticleAcademicpeer-review

    76 Citations (Scopus)
  • Genome-wide analysis identifies 12 loci influencing human reproductive behavior

    Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., Shen, X., Wilson, J. F., Chasman, D. I., Nolte, I. M., Tragante, V., van der Laan, S. W., Perry, J. R. B., Kong, A., Ahluwalia, T. S., Albrecht, E., Yerges-Armstrong, L., Atzmon, G., Auro, K., Ayers, K., & 232 othersBakshi, A., Ben-Avraham, D., Berger, K., Bergman, A., Bertram, L., Bielak, L. F., Bjornsdottir, G., Bonder, M. J., Broer, L., Bui, M., Barbieri, C., Cavadino, A., Chavarro, J. E., Turman, C., Concas, M. P., Cordell, H. J., Davies, G., Eibich, P., Eriksson, N., Esko, T., Eriksson, J., Falahi, F., Felix, J. F., Fontana, M. A., Franke, L., Gandin, I., Gaskins, A. J., Gieger, C., Gunderson, E. P., Guo, X., Hayward, C., He, C., Hofer, E., Huang, H., Joshi, P. K., Kanoni, S., Karlsson, R., Kiechl, S., Kifley, A., Kluttig, A., Kraft, P., Lagou, V., Lecoeur, C., Lahti, J., Li-Gao, R., Lind, P. A., Liu, T., Makalic, E., Mamasoula, C., Matteson, L., Mbarek, H., McArdle, P. F., McMahon, G., Meddens, S. F. W., Mihailov, E., Miller, M., Missmer, S. A., Monnereau, C., van der Most, P. J., Myhre, R., Nalls, M. A., Nutile, T., Kalafati, I. P., Porcu, E., Prokopenko, I., Rajan, K. B., Rich-Edwards, J., Rietveld, C. A., Robino, A., Rose, L. M., Rueedi, R., Ryan, K-A., Saba, Y., Schmidt, D., Smith, J. A., Stolk, L., Streeten, E., Toenjes, A., Thorleifsson, G., Ulivi, S., Wedenoja, J., Wellmann, J., Willeit, P., Yao, J., Yengo, L., Zhao, J. H., Zhao, W., Zhernakova, D. V., Amin, N., Andrews, H., Balkau, B., Barzilai, N., Bergmann, S., Biino, G., Bisgaard, H., Bonnelykke, K., Boomsma, D. I., Buring, J. E., Campbell, H., Cappellani, S., Ciullo, M., Cox, S. R., Cucca, F., Toniolo, D., Davey-Smith, G., Deary, I. J., Dedoussis, G., Deloukas, P., van Duijn, C. M., de Geus, E. J. C., Eriksson, J. G., Evans, D. A., Faul, J. D., Sala, C. F., Froguel, P., Gasparini, P., Girotto, G., Grabe, H-J., Greiser, K. H., Groenen, P. J. F., de Haan, H. G., Haerting, J., Harris, T. B., Heath, A. C., Heikkila, K., Hofman, A., Homuth, G., Holliday, E. G., Hopper, J., Hypponen, E., Jacobsson, B., Jaddoe', V. W. V., Johannesson, M., Kahonen, M., Kajantie, E., Kardia, S. L. R., Keavney, B., Kolcic, I., Koponen, P., Kovacs, P., Kronenberg, F., Kutalik, Z., La Bianca, M., Lachance, G., Iacono, W. G., Lai, S., Lehtimaki, T., Liewald, D. C., Lindgren, C. M., Liu, Y., Luben, R., Lucht, M., Luoto, R., Magnus, P., Magnusson, P. K. E., Martin, N. G., McGue, M., McQuillan, R., Medland, S. E., Meisinger, C., Mellstrom, D., Metspalu, A., Traglia, M., Milani, L., Mitchell, P., Montgomery, G. W., Mook-Kanamori, D., de Mutsert, R., Nohr, E. A., Ohlsson, C., Olsen, P., Ong, K. K., Paternoster, L., Pattie, A., Penninx, B. W. J. H., Perola, M., Peyser, P. A., Pirastu, M., Polasek, O., Power, C., Kaprio, J., Raffel, L. J., Raikkonen, K., Raitakari, O., Ridker, P. M., Ring, S. M., Roll, K., Rudan, I., Ruggiero, D., Rujescu, D., Salomaa, V., Schlessinger, D., Schmidt, H., Schmidt, R., Schupf, N., Smit, J., Sorice, R., Spector, T. D., Starr, J. M., Stockl, D., Strauch, K., Stumvoll, M., Swertz, M. A., Thorsteinsdottir, U., Thurik, A. R., Timpson, N. J., Tung, J. Y., Uitterlinden, A. G., Vaccargiu, S., Viikari, J., Vitart, V., Voelzke, H., Vollenweider, P., Vuckovic, D., Waage, J., Wagner, G. G., Wang, J. J., Wareham, N. J., Weir, D. R., Willemsen, G., Willeit, J., Wright, A. F., Zondervan, K. T., Stefansson, K., Krueger, R. F., Lee, J. J., Benjamin, D. J., Cesarini, D., Koellinger, P. D., den Hoed, M., Snieder, H. & Mills, M. C., Dec 2016, In: Nature Genetics. 48, 12, p. 1462-1472

    Research output: Contribution to JournalArticleAcademicpeer-review

    143 Citations (Scopus)
  • Identification of context-dependent expression quantitative trait loci in whole blood

    Zhernakova, D. V., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., van Dongen, J., & 28 othersHottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Zhernakova, A., Li, Y., Tigchelaar, E. F., de Klein, N., Beekman, M., Deelen, J., van Heemst, D., van den Berg, L. H., Hofman, A., Uitterlinden, A. G., Van Greevenbroek, M. J., Veldink, J. H., Boomsma, D. I., van Duijn, C. M., Wijmenga, C., Slagboom, P. E., Swertz, M. A., Isaacs, A., van Meurs, J. B. J., Jansen, R., Heijmans, B. T., ’t Hoen, P. A. C., Franke, L. & Hoen't, P. A. C., Jan 2017, In: Nature Genetics. 49, 1, p. 139-145 7 p.

    Research output: Contribution to JournalArticleAcademicpeer-review

    209 Citations (Scopus)
  • Integrative approaches for large-scale transcriptome-wide association studies

    Gusev, A., Ko, A., Shi, H., Bhatia, G., Chung, W., Penninx, B. W. J. H., Jansen, R., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., Sullivan, P. F., Nikkola, E., Alvarez, M., Civelek, M., Lusis, A. J., Lehtimaki, T., Raitoharju, E., Kahonen, M., Seppala, I., Raitakari, O. T., & 8 othersKuusisto, J., Laakso, M., Price, A. L., Pajukanta, P., Pasaniuc, B., Lehtimäki, T., Kähönen, M. & Seppälä, I., Mar 2016, In: Nature Genetics. 48, 3, p. 245-252

    Research output: Contribution to JournalArticleAcademicpeer-review

    809 Citations (Scopus)