Projects per year
Personal profile
Research interests
My research focuses on identifying the (integrative) omics signature of depression (using DNA, methylation, gene expression, proteomics) and on finding better treatment for, and identification of, depression subtypes, mainly using data from NESDA (The Netherlands Study of Depression and Anxiety) and NTR (The Netherlands Twin Registry).
I am co PI of PERCIM (Personalized Care for Immuno-Metabolic Depression) (https://psychiatryamsterdam.nl/project/percim/) and was part of the BIOS (Biobank-based integrative omics study) consortium management (https://www.bbmri.nl/acquisition-use-analyze/bios). As NESDA, NTR and BIOS we are part of the large eQTL meta analysis: the eQTLGen Consortium (https://www.eqtlgen.org/).
I am teaching a course on human molecular genetics for the research master 'Genes in Behaviour and Health' (https://vuweb.vu.nl/nl/onderwijs/master/genes-in-behaviour-and-health).
For the publication I (co) authored see my google scholar page: https://scholar.google.nl/citations?user=cHJDM0YAAAAJ&hl=en.
And for the publications from the Consortia I participated in see:
BIOS: https://pubmed.ncbi.nlm.nih.gov/?term=BIOS+Consortium%5BCorporate+Author%5D&sort=date.
eQTLGen: https://pubmed.ncbi.nlm.nih.gov/?sort=date&term=eQTLGen+Consortium%5BCorporate+Author%5D.
See also our conditional eQTL catalog based on NESDA and NTR data:
And the Methylation and RNA-seq QTL catalogs from BIOS:
Email: ri.jansen at amsterdamumc.nl
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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PERCIM: Personalized Care for Depression: Bringing Immuno-Metabolic Depression from Bench to Bedside
Lamers, F., Jansen, R., Vreijling, S., Penninx, B., Beekman, A., Bot, M., Milaneschi, Y., Bremmer, M. & Rhebergen, D.
1/10/2019 → 31/10/2024
Project: Research
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Gene expression in major depressive disorder
Jansen, R., Penninx, B. W. J. H., Madar, V., Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A. T. F., van der Wee, N., Smit, J. H., Brooks, A. I., Tischfield, J., Posthuma, D., Schoevers, R., Grootheest, G., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., Zou, F., & 2 others, 2016, In: Molecular psychiatry. 21, p. 339-347 347 p.Research output: Contribution to journal › Article › Academic › peer-review
148 Citations (Scopus) -
Effects of dietary interventions on depressive symptom profiles: Results from the MooDFOOD depression prevention study
Vreijling, S. R., Penninx, B. W. J. H., Bot, M., Watkins, E., Owens, M., Kohls, E., Hegerl, U., Roca, M., Gili, M., Brouwer, I. A., Visser, M., Beekman, A. T. F., Jansen, R. & Lamers, F., 7 Nov 2022, In: Psychological Medicine. 52, 15, p. 3580-3589 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus) -
An integrative study of five biological clocks in somatic and mental health
Jansen, R., Han, L. K. M., Verhoeven, J. E., Aberg, K. A., van den Oord, E. C. G. J., Milaneschi, Y. & Penninx, B. W. J. H., Feb 2021, In: eLife. 10, p. 1-20 20 p., e59479.Research output: Contribution to journal › Article › Academic › peer-review
Open Access41 Citations (Scopus) -
Dissection of depression heterogeneity using proteomic clusters
van Haeringen, M., Milaneschi, Y., Lamers, F., Penninx, B. W. J. H. & Jansen, R., 18 May 2023, In: Psychological Medicine. 53, 7, p. 2904-2912 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access8 Citations (Scopus)
Datasets
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Additional file 7: of Blood lipids influence DNA methylation in circulating cells
Dekkers, K. (Contributor), Iterson, M. V. (Contributor), Slieker, R. (Contributor), Moed, M. (Contributor), Bonder, M. (Contributor), Galen, M. V. (Contributor), Mei, H. (Contributor), Zhernakova, D. (Contributor), Berg, L. V. D. (Contributor), Deelen, J. (Contributor), Dongen, J. V. (Contributor), Heemst, D. V. (Contributor), Hofman, A. (Contributor), Hottenga, J. (Contributor), Kallen, C. V. D. (Contributor), Schalkwijk, C. (Contributor), Stehouwer, C. (Contributor), Tigchelaar, E. (Contributor), Uitterlinden, A. (Contributor), Willemsen, G. (Contributor), Zhernakova, A. (Contributor), Franke, L. (Contributor), Hoen, P. (Contributor), Jansen, R. (Contributor), Meurs, J. V. (Contributor), Boomsma, D. (Contributor), Duijn, C. V. (Contributor), Greevenbroek, M. V. (Contributor), Veldink, J. (Contributor), Wijmenga, C. (Contributor), Zwet, E. V. (Contributor), Slagboom, P. (Contributor), Jukema, J. (Contributor) & Heijmans, B. (Contributor), Unknown Publisher, 27 Jun 2016
DOI: 10.6084/m9.figshare.c.3596987_d1.v1, https://springernature.figshare.com/articles/dataset/Additional_file_7_of_Blood_lipids_influence_DNA_methylation_in_circulating_cells/4320521/1
Dataset
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Additional file 10: of Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Slieker, R. (Contributor), Iterson, M. V. (Contributor), Luijk, R. (Contributor), Beekman, M. (Contributor), Zhernakova, D. (Contributor), Moed, M. (Contributor), Mei, H. (Contributor), Galen, M. V. (Contributor), Deelen, P. (Contributor), Bonder, M. (Contributor), Zhernakova, A. (Contributor), Uitterlinden, A. (Contributor), Tigchelaar, E. (Contributor), Stehouwer, C. (Contributor), Schalkwijk, C. (Contributor), Kallen, C. V. D. (Contributor), Hofman, A. (Contributor), Heemst, D. V. (Contributor), Geus, E. D. (Contributor), Dongen, J. V. (Contributor), Deelen, J. (Contributor), Berg, L. V. D. (Contributor), Meurs, J. V. (Contributor), Jansen, R. (Contributor), Hoen, P. (Contributor), Franke, L. (Contributor), Wijmenga, C. (Contributor), Veldink, J. (Contributor), Swertz, M. (Contributor), Greevenbroek, M. V. (Contributor), Duijn, C. V. (Contributor), Boomsma, D. (Contributor), Slagboom, P. (Contributor) & Heijmans, B. (Contributor), Unknown Publisher, 22 Sept 2016
DOI: 10.6084/m9.figshare.c.3602444_d10.v1, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_Age-related_accrual_of_methylomic_variability_is_linked_to_fundamental_ageing_mechanisms/4336805/1
Dataset
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Additional file 5: of Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Slieker, R. (Contributor), Iterson, M. V. (Contributor), Luijk, R. (Contributor), Beekman, M. (Contributor), Zhernakova, D. (Contributor), Moed, M. (Contributor), Mei, H. (Contributor), Galen, M. V. (Contributor), Deelen, P. (Contributor), Bonder, M. (Contributor), Zhernakova, A. (Contributor), Uitterlinden, A. (Contributor), Tigchelaar, E. (Contributor), Stehouwer, C. (Contributor), Schalkwijk, C. (Contributor), Kallen, C. V. D. (Contributor), Hofman, A. (Contributor), Heemst, D. V. (Contributor), Geus, E. D. (Contributor), Dongen, J. V. (Contributor), Deelen, J. (Contributor), Berg, L. V. D. (Contributor), Meurs, J. V. (Contributor), Jansen, R. (Contributor), Hoen, P. (Contributor), Franke, L. (Contributor), Wijmenga, C. (Contributor), Veldink, J. (Contributor), Swertz, M. (Contributor), Greevenbroek, M. V. (Contributor), Duijn, C. V. (Contributor), Boomsma, D. (Contributor), Slagboom, P. (Contributor) & Heijmans, B. (Contributor), Unknown Publisher, 22 Sept 2016
DOI: 10.6084/m9.figshare.c.3602444_d5.v1, https://springernature.figshare.com/articles/dataset/Additional_file_5_of_Age-related_accrual_of_methylomic_variability_is_linked_to_fundamental_ageing_mechanisms/4336721/1
Dataset
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Additional file 12: of Blood lipids influence DNA methylation in circulating cells
Dekkers, K. (Contributor), Iterson, M. V. (Contributor), Slieker, R. (Contributor), Moed, M. (Contributor), Bonder, M. (Contributor), Galen, M. V. (Contributor), Mei, H. (Contributor), Zhernakova, D. (Contributor), Berg, L. V. D. (Contributor), Deelen, J. (Contributor), Dongen, J. V. (Contributor), Heemst, D. V. (Contributor), Hofman, A. (Contributor), Hottenga, J. (Contributor), Kallen, C. V. D. (Contributor), Schalkwijk, C. (Contributor), Stehouwer, C. (Contributor), Tigchelaar, E. (Contributor), Uitterlinden, A. (Contributor), Willemsen, G. (Contributor), Zhernakova, A. (Contributor), Franke, L. (Contributor), Hoen, P. (Contributor), Jansen, R. (Contributor), Meurs, J. V. (Contributor), Boomsma, D. (Contributor), Duijn, C. V. (Contributor), Greevenbroek, M. V. (Contributor), Veldink, J. (Contributor), Wijmenga, C. (Contributor), Zwet, E. V. (Contributor), Slagboom, P. (Contributor), Jukema, J. (Contributor) & Heijmans, B. (Contributor), Unknown Publisher, 27 Jun 2016
DOI: 10.6084/m9.figshare.c.3596987_d7.v1, https://springernature.figshare.com/articles/dataset/Additional_file_12_of_Blood_lipids_influence_DNA_methylation_in_circulating_cells/4320629/1
Dataset
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Additional file 9 of Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference
Hop, P. J. (Contributor), Luijk, R. (Contributor), Daxinger, L. (Contributor), Iterson, M. V. (Contributor), Dekkers, K. F. (Contributor), Jansen, R. (Contributor), Meurs, J. B. J. V. (Contributor), Hoen, P. A. C. ’. (Contributor), Ikram, M. A. (Contributor), Greevenbroek, M. M. J. V. (Contributor), Boomsma, D. I. (Contributor), Slagboom, P. E. (Contributor), Veldink, J. H. (Contributor), Zwet, E. W. V. (Contributor) & Heijmans, B. T. (Contributor), Unknown Publisher, 1 Jan 2020
DOI: 10.6084/m9.figshare.12891519.v1, https://springernature.figshare.com/articles/dataset/Additional_file_9_of_Genome-wide_identification_of_genes_regulating_DNA_methylation_using_genetic_anchors_for_causal_inference/12891519/1
Dataset