Rick Jansen

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Rick Jansen

 https://orcid.org/0000-0002-3333-6737
20092023

Research activity per year

Search results

  • 2020

    Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies

    eQTLGen Consortium, BIOS consortium, Bartels, M., Wray, N. R., Middeldorp, C. M., Prokisch, H., Psaty, B. M., Raitakari, O. T., Ripatti, S., Rotzschke, O., Rüeger, S., Saha, A., Scholz, M., Schramm, K., Seppälä, I., Slagboom, P. E., Stehouwer, C. D. A., Stumvoll, M., Sullivan, P., ‘t Hoen, P. A. C., & 62 othersTeumer, A., Thiery, J., Tong, L., Tönjes, A., Van Iterson, M., Van Meurs, J., Veldink, J. H., Verlouw, J., Visscher, P. M., Völker, U., Võsa, U., Westra, H., Wijmenga, C., Yaghootkar, H., Yang, J., Zeng, B., Zhang, F., ‘t Hoen, P. A. C., Van Meurs, J., Isaacs, A., Pool, R., Hottenga, J. J., Van Greevenbroek, M. M., Stehouwer, C. D. A., Van Der Kallen, C. J. H., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., Van Heemst, D., Veldink, J. H., Van Den Berg, L. H., Van Duijn, C. M., Hofman, B. A., Isaacs, A., Uitterlinden, A. G., Van Meurs, J., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., Van Der Breggen, R., Van Rooij, J., Lakenberg, N., Van Iterson, M., Van Galen, M., Bot, J., Zhernakova, D. V., Hof, P. V. ., Nooren, I., Moed, M., Vermaat, M., Zhernakova, D. V., Luijk, R., Van Iterson, M., Van Galen, M., Kielbasa, S. M., Swertz, M. A., Van Zwet, E. W. & Hoen, P. ., 15 Sept 2020, In: Biological Psychiatry. 88, 6, p. 470-479 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    12 Citations (Scopus)
  • 2019

    A linear mixed-model approach to study multivariate gene-environment interactions

    BIOS consortium, 1 Jan 2019, In: Nature Genetics. 51, 1, p. 180-186 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    78 Citations (Scopus)

  • Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for Major Depressive Disorder and white matter microstructure in the UK Biobank

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, 1 Jan 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    17 Citations (Scopus)

  • Epigenome-wide association study of Attention-Deficit/Hyperactivity Disorder symptoms in adults

    BIOS consortium, 15 Oct 2019, In: Biological Psychiatry. 86, 8, p. 599-607 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    39 Citations (Scopus)

  • Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

    BIOS consortium, 14 Nov 2019, In: Genome Biology. 20, 1, p. 235 235.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    20 Citations (Scopus)

  • Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

    Social Science Genetic Association Consortium, 23and Me Research Team, eQTLGen Consortium & International Cannabis Consortium, 1 Feb 2019, In: Nature Genetics. 51, 2, p. 245-257 13 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    349 Citations (Scopus)

  • Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

    eQTLGen Consortium, 15 Jan 2019, In: eLife. 8, p. 1-40 40 p., e39856.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    138 Citations (Scopus)

  • Identification of common genetic risk variants for autism spectrum disorder

    Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, 1 Mar 2019, In: Nature Genetics. 51, 3, p. 431-444 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    1127 Citations (Scopus)

  • Involvement of inflammatory gene expression pathways in depressed patients with hyperphagia

    de Kluiver, H., Jansen, R., Milaneschi, Y. & Penninx, B. W. J. H., 1 Dec 2019, In: Translational Psychiatry. 9, 1, 193.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    15 Citations (Scopus)

  • Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

    eQTLGen Consortium & BIOS consortium, 1 Dec 2019, In: Nature communications. 10, 1, 3300.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    133 Citations (Scopus)

  • Methylome-wide association studies for Major Depressive Disorder in blood overlap with methylation results from brain and large-scale GWAS

    Aberg, K., Dean, B., Shabalin, A., Zhao, M., Chan, R., Hattab, M., van Grootheest, G., Han, L., Aghajani, M., Milaneschi, Y., Jansen, R., Xie, L., Clark, S., Penninx, B. & van den Oord, E., 2019, In: European neuropsychopharmacology. 29, p. S807-S808

    Research output: Contribution to journal › Meeting Abstract › Academic

  • Multivariate genome-wide analyses of the well-being spectrum

    BIOS consortium & Social Science Genetic Association Consortium, 1 Mar 2019, In: Nature Genetics. 51, 3, p. 445-451 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    161 Citations (Scopus)

  • RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting

    GoNL Consortium, 24 Jun 2019, In: Biology. 17, 1, p. 50

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    18 Citations (Scopus)

  • Skewed X-inactivation is common in the general female population

    BIOS consortium, 1 Mar 2019, In: European journal of human genetics. 27, 3, p. 455-465 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    88 Citations (Scopus)
  • 2018

    Accelerated biological aging in major depressive disorder: capturing aging patterns in DNA methylation with machine learning methods

    Han, L., Aghajani, M., Clark, S., Hattab, M., Shabalin, A., Zhao, M., Kumar, G., Chan, R., Xie, L., Jansen, R., Milaneschi, Y., Aberg, K., Van den Oord, E. & Penninx, B., Mar 2018, In: European neuropsychopharmacology. 28, p. S85-S86

    Research output: Contribution to journal › Meeting Abstract › Academic

    42 Citations (Scopus)

  • A characterization of post-zygotic mutations identified in monozygotic twins

    Ouwens, K. G., Jansen, R., Tolhuis, B., Slagboom, P. E., Penninx, B. W. J. H. & Boomsma, D. I., 1 Oct 2018, In: Human mutation. 39, 10, p. 1393-1401 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    8 Citations (Scopus)

  • Analysis of shared heritability in common disorders of the brain

    The Brainstorm Consortium, 22 Jun 2018, In: Science. 360, 6395, p. 1-15 15 p., 8757.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    1251 Citations (Scopus)

  • A SNP panel for identification of DNA and RNA specimens

    BIOS consortium, 25 Jan 2018, In: BMC Genomics. 19, 1, p. 90 90.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    30 Citations (Scopus)

  • Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

    BIOS consortium, 14 Sept 2018, In: Nature communications. 9, 1, p. 1-9 9 p., 3738.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    17 Citations (Scopus)

  • Characterizing the Relation Between Expression QTLs and Complex Traits: Exploring the Role of Tissue Specificity

    UK Brain Expression Consortium & Consortium, UK. B. E., 1 Sept 2018, In: Behavior genetics. 48, 5, p. 374-385 12 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    8 Citations (Scopus)

  • DNA methylation signatures of educational attainment

    BIOS consortium, 23 Mar 2018, In: NPJ Science of Learning. 3, 1, p. 1-14 14 p., 7.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    41 Citations (Scopus)

  • Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 15 Jul 2018, In: Biological Psychiatry. 84, 2, p. 138-147 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    73 Citations (Scopus)

  • Epigenetic aging in major depressive disorder

    Han, L. K. M., Aghajani, M., Clark, S. L., Chan, R. F., Hattab, M. W., Shabalin, A. A., Zhao, M., Kumar, G., Xie, L. Y., Jansen, R., Milaneschi, Y., Dean, B., Aberg, K. A., Van Den Oord, E. J. C. G. & Penninx, B. W. J. H., 1 Aug 2018, In: American Journal of Psychiatry. 175, 8, p. 774-782 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    148 Citations (Scopus)

  • Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x)

    the Million Veteran Program, 1 Oct 2018, In: Nature Genetics. 50, 12, 1 p.

    Research output: Contribution to journal › Erratum/Corrigendum › Academic › peer-review

    17 Citations (Scopus)

  • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

    the Million Veteran Program, Oct 2018, In: Nature Genetics. 50, 10, p. 1412-1431 20 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    749 Citations (Scopus)

  • Genome-wide analysis of DNA methylation in buccal cells: A study of monozygotic twins and mQTLs

    Van Dongen, J., Ehli, E. A., Jansen, R., Van Beijsterveldt, C. E. M., Willemsen, G., Hottenga, J. J., Kallsen, N. A., Peyton, S. A., Breeze, C. E., Kluft, C., Heijmans, B. T., Bartels, M., Davies, G. E. & Boomsma, D. I., 25 Sept 2018, In: Epigenetics and Chromatin. 11, 1, p. 1-14 14 p., 54.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    35 Citations (Scopus)

  • Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

    eQTLGen Consortium, 1 Dec 2018, In: Nature communications. 9, 1, 14 p., 2941.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    455 Citations (Scopus)

  • Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

    Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., & 196 othersCastelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M. G., Posthuma, D., Smit, J. H., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Escott-Price, V., Kiadeh, F. H. F., Finucane, H. K., Forstner, A. J., Frank, J., Gaspar, H. L. A., Gill, M., Giusti-Rodríguez, P., Goes, F. S., Gordon, S. D., Grove, J., Hall, L. S., Hannon, E., Hansen, C. S. H., Hansen, T. F., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Horn, C., Hougaard, D. M., Hu, M., Hyde, C. L., Ising, M., Jansen, R., Jin, F., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Krogh, J., Kutalik, Z., Lane, J. M., Li, Y., Li, Y., Lind, P. A., Liu, X., Lu, L., MacIntyre, D. J., MacKinnon, D. F., Maier, R. M., Maier, W., Marchini, J., McGrath, P., McGuffin, P., Medland, S. E., Mehta, D. I., Mihailov, E., Milani, L., Mill, J., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nyholt, D. R., O'Reilly, P. F., Oskarsson, H., Owen, M. J., Painter, J. N., Pedersen, C. B. C., Pedersen, M. G., Peterson, R. E., Pettersson, E., Peyrot, W. J., Pistis, G., Purcell, S. M., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Rivera, M., Saeed Mirza, S., Saxena, R., Schoevers, R., Schulte, E. C., Shen, L., Shi, J., Shyn, S. I., Sigurdsson, E., Sinnamon, G. B. C., Smith, D. J., Stefansson, H., Steinberg, S., Stockmeier, C. A., Streit, F., Strohmaier, J., Tansey, K. E., Teismann, H., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Tian, C., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A. G., Umbricht, D., van der Auwera, S., van Hemert, A. M., Viktorin, A., Visscher, P. M., Wang, Y., Webb, B. T., Weinsheimer, S. M., Wellmann, J. R., Witt, S. H., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Arolt, V., Baune, B. T., Berger, K., Cichon, S., Dannlowski, U., de Geus, E. C. J., Depaulo, J. R., Domenici, E., Domschke, K., Esko, T. N., Grabe, H. J., Hamilton, S. P., Hayward, C., Heath, A. C., Hinds, D. A., Kendler, K. S., Kloiber, S., Lewis, G., Li, Q. S., Lucae, S., Madden, P. F. A., Magnusson, P. K., Martin, N. G., McIntosh, A. M., Metspalu, A., Mors, O., Mortensen, P. B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M. M., O'Donovan, M. C., Paciga, S. A., Pedersen, N. L., Perlis, R. H., Porteous, D. J., Potash, J. B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M. M., Werge, T., Winslow, A. R., Lewis, C. M., Levinson, D. F., Breen, G., Børglum, A. D. & Sullivan, P. F., 1 May 2018, In: Nature Genetics. 50, 5, p. 668-681 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    1650 Citations (Scopus)

  • Genome-wide identification of directed gene networks using large-scale population genomics data

    BIOS (Biobank-based Integrative Omics Study) Consortium, 6 Aug 2018, In: Nature communications. 9, 1, p. 1-10 10 p., 3097.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    11 Citations (Scopus)

  • Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

    Generation Scotland, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Hottenga, J. J., Mbarek, H., Nivard, M. G., Willemsen, G. & Boomsma, D. I., 1 Dec 2018, In: PLOS ONE. 13, 12, p. 1-29 29 p., e0209160.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    11 Citations (Scopus)

  • Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

    eQTLGen Consortium, Jansen, R., Nauck, M., Perola, M., Pervjakova, N., Pierce, B., Powell, J., Prokisch, H., Psaty, B., Raitakari, O., Ring, S., Ripatti, S., Rotzschke, O., Ruëger, S., Saha, A., Scholz, M., Schramm, K., Seppälä, I., Stumvoll, M., Sullivan, P., & 17 othersTeumer, A., Thiery, J., Tong, L., Tönjes, A., Van Meurs, J., Verlouw, J., Völker, U., Võsa, U., Yaghootkar, H., Zeng, B., Marioni, R. E., Montgomery, G. W., Deary, I. J., Wray, N. R., Visscher, P. M., McRae, A. F. & Yang, J., 1 Dec 2018, In: Nature communications. 9, 1, 2282.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    199 Citations (Scopus)

  • Telomere Length, Epigenetic Aging and Depression in the Netherlands Study of Depression and Anxiety (NESDA)

    Han, L., Verhoeven, J., Aghajani, M., Clark, S., Hattab, M., Shabalin, A., Zhao, M., Kumar, G., Chan, R., Xie, L. Y., Milaneschi, Y., Jansen, R., Aberg, K., van den Oord, E. & Penninx, B., 1 May 2018, In: Biological Psychiatry. 83, 9, p. S17-S17

    Research output: Contribution to journal › Meeting Abstract › Academic

  • 2017

    2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio

    Lin, B. D., Carnero-Montoro, E., Bell, J. T., Boomsma, D. I., de Geus, E. J., Jansen, R., Kluft, C., Mangino, M., Penninx, B., Spector, T. D., Willemsen, G. & Hottenga, J-J., Nov 2017, In: Journal of Human Genetics. 62, 11, p. 979-988 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    14 Citations (Scopus)

  • Conditional eQTL analysis reveals allelic heterogeneity of gene expression

    Jansen, R., Hottenga, J. J., Nivard, M. G., Abdellaoui, A., Laport, B., de Geus, E. J., Wright, F. A., Penninx, B. W. J. H. & Boomsma, D. I., 15 Apr 2017, In: Human Molecular Genetics. 26, 8, p. 1444-1451 8 p., ddx043.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    93 Citations (Scopus)

  • Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

    van Iterson, M., van Zwet, E. W., Heijmans, B. T., ’t Hoen, P. A. C., van Meurs, J. B. J., Jansen, R., Franke, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Eline Slagboom, P., Beekman, M., & 32 othersDeelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Isaacs, A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Galen, M., Bot, J., Zhernakova, D. V., van 't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Luijk, R., Bonder, M. J., van Dijk, F., Arindrarto, W., Kielbasa, S. M., Swertz, M. A., 't Hoen, P. B. & 't Hoen, P. A. C., 27 Jan 2017, In: Genome Biology. 18, 1, 19.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    193 Citations (Scopus)

  • Correcting for cell-type effects in DNA methylation studies: Reference-based method outperforms latent variable approaches in empirical studies

    Hattab, M. W., Shabalin, A. A., Clark, S. L., Zhao, M., Kumar, G., Chan, R. F., Xie, L. Y., Jansen, R., Han, L. K. M., Magnusson, P. K. E., van Grootheest, G., Hultman, C. M., Penninx, B. W. J. H., Aberg, K. A. & van den Oord, E. J. C. G., 30 Jan 2017, In: Genome Biology. 18, 1, 24.

    Research output: Contribution to journal › Letter › Academic › peer-review

    20 Citations (Scopus)

  • C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis

    eQTLGen Consortium, 1 Sept 2017, In: PLoS computational biology. 13, 9, p. e1005766 e1005766.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    26 Citations (Scopus)

  • Differential gene expression patterns between smokers and non-smokers: cause or consequence?

    Vink, J. M., Jansen, R., Brooks, A., Willemsen, G., van Grootheest, G., de Geus, E., Smit, J. H., Penninx, B. W. & Boomsma, D. I., 1 Mar 2017, In: Addiction Biology. 22, 2, p. 550-560 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    50 Citations (Scopus)

  • Disease variants alter transcription factor levels and methylation of their binding sites

    the BIOS Consortium, 1 Jan 2017, In: Nature Genetics. 49, 1, p. 131-138 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    288 Citations (Scopus)

  • Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

    Australian Asthma Genetics Consortium Collaborators, 1 Apr 2017, In: Journal of allergy and clinical immunology. 139, 4, p. 1148-1157 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    56 Citations (Scopus)

  • Genetic effects influencing risk for major depressive disorder in China and Europe

    Edwards, C. A., McGuffin, P., McIntosh, A. M., Medland, S. E., Mehta, D., Montgomery, G. W., Mors, O., Müller-Myhsok, B., Nauck, M., Nyholt, D. R., Nöthen, M. M., Owen, M. J., Pergadia, M. L., Perlis, R. H., Porteous, D. J., Potash, J. B., Rice, J. P., Rietschel, M., Riley, B. P., Rivera, M., & 23 othersSchulze, T. G., Shi, J., Shyn, S. I., Smoller, J. W., Streit, F., Strohmaier, J., Teumer, A., Treutlein, J., van der Auwera, S. V., van Hemert, A. M., Völzke, H., Webb, B. T., Weissman, M. M., Wellmann, J., Willemsen, G., Witt, S. H., Levinson, D. F., Lewis, C. M., Wray, N. R., Flint, J., Sullivan, P. F., Kendler, K. S. & on behalf of the CONVERGE consortium and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 28 Mar 2017, In: Translational Psychiatry. 7, 3, p. e1074 e1074.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    51 Citations (Scopus)

  • Genetic loci associated with heart rate variability and their effects on cardiac disease risk

    Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., Von Der Heyde, B., Avery, C. L., Bis, J. C., Dierckx, B., Van Dongen, J., Gogarten, S. M., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S. J., Jaju, D., Kerr, K. F., Kluttig, A., Krijthe, B. P., & 144 othersKumar, J., Van Der Laan, S. W., Lyytikäinen, L. P., Maihofer, A. X., Minassian, A., Van Der Most, P. J., Müller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J. D., Thayer, J. F., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M. H., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D. G., De Bakker, P. I. W., Barcella, M., Bayoumi, R., Bieringa, R. J., Boomsma, D., Boucher, G., Britton, A. R., Christophersen, I. E., Dietrich, A., Ehret, G. B., Ellinor, P. T., Eskola, M., Felix, J. F., Floras, J. S., Franco, O. H., Friberg, P., Gademan, M. G. J., Geyer, M. A., Giedraitis, V., Hartman, C. A., Hemerich, D., Hofman, A., Hottenga, J. J., Huikuri, H., Hutri-Kähönen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A. M., Kors, J. A., Kumari, M., Kuznetsova, T., Laurie, C. C., Lefrandt, J. D., Li, Y., Li, Y., Liao, D., Limacher, M. C., Lin, H. J., Lindgren, C. M., Lubitz, S. A., Mahajan, A., McKnight, B., Meyer Zu Schwabedissen, H., Milaneschi, Y., Mononen, N., Morris, A. P., Nalls, M. A., Navis, G., Neijts, M., Nikus, K., North, K. E., O'Connor, D. T., Ormel, J., Perz, S., Peters, A., Psaty, B. M., Raitakari, O. T., Risbrough, V. B., Sinner, M. F., Siscovick, D., Smit, J. H., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Staessen, J. A., Stein, P. K., Stilp, A. M., Stolarz-Skrzypek, K., Strauch, K., Sundström, J., Swenne, C. A., Syvänen, A. C., Tardif, J. C., Taylor, K. D., Teumer, A., Thornton, T. A., Tinker, L. E., Uitterlinden, A. G., Van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K. C., Willemsen, G., Wong, Q., Zhang, Z. M., Zonderman, A. B., Cusi, D., Evans, M. K., Greiser, H. K., Van Der Harst, P., Hassan, M., Ingelsson, E., Järvelin, M. R., Kääb, S., Kähönen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimäki, T., Lind, L., Nievergelt, C. M., O'Donnell, C. J., Oldehinkel, A. J., Penninx, B., Reiner, A. P., Riese, H., Van Roon, A. M., Rioux, J. D., Rotter, J. I., Sofer, T., Stricker, B. H., Tiemeier, H., Vrijkotte, T. G. M., Asselbergs, F. W., Brundel, B. J. J. M., Heckbert, S. R., Whitsel, E. A., Den Hoed, M., Snieder, H. & De Geus, E. J. C., 14 Jun 2017, In: Nature Communications. 8, p. 15805 15805.

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  • Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

    The International Consortium of Blood Pressure (ICBP) 1000G Analyses, The CHD Exome+ Consortium, The ExomeBP Consortium, The T2D-GENES Consortium, The GoT2DGenes Consortium, The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, The International Genomics of Blood Pressure (iGEN -BP) Consortium, for The UK Biobank CardioMetabolic Consortium BP working group Louise, BIOS consortium, LifeLines Cohort Study, Understanding Society Scientific Group, Magi, R., Newton-Cheh, C., Lindgren, C. M., Levy, D., Kooner, J. S., Keavney, B., Tomaszewski, M., Samani, N. J., Howson, J. M. M., & 209 othersTobin, M. D., Munroe, P. B., Ehret, G. B., Wain, L. V., Barnes, M. R., Tzoulaki, J., Caulfield, M. J., Elliott, P., Vaez, A., Joehanes, R., van der Most, P. J., Erzurumluoglu, A. M., Rose, L. M., Verwoert, G. C., Hottenga, J-J., Strawbridge, R. J., Arking, D. E., Hwang, S-J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N., Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikainen, L-P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sober, S., Vuckovic, D., Luan, J., del Greco, F. M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Gandin, I., Harris, S. E., Zemonik, T., Lu, Y., Shah, N., de Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Batini, C., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brumat, M., Campbell, H., Cocca, M., Collins, F., Cordell, H. J., Damman, J. J., Davies, G., de Geus, E. J., de Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dorr, M., Ferreira, T., Franberg, M., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Jarvelin, M-R., Johansson, A., Johnson, A. D., Jousilahti, P., Jula, A., Kahonen, M., Kathiresan, S., Khaw, K-T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Palotie, A., Pare, G., Pattie, A., Pramstaller, P. P., Raitakari, O. T., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A-P., Schmidt, R., Scott, R., Seelen, M. A., Siscovick, D., Sorice, R., Stott, D. J., Sundstrom, J., Swertz, M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Volker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Theriault, S., Conen, D., John, A., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Palmer, C. N. A., Vergnaud, A-C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Lindgren, C. M., Vitart, V., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimaki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M. & Morris, A. P., 1 Mar 2017, In: Nature Genetics. 49, 3, p. 403-415 13 p.

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  • Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

    Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T. M., Rosmalen, J. G., Verweij, N., Dullaart, R. P., Mahajan, A., Lindgren, C. M., Morris, A., Lind, L., Ingelsson, E., Anderson, L. N., Pennell, C. E., Lye, S. J., Matthews, S. G., & 176 othersEriksson, J., Mellstrom, D., Ohlsson, C., Price, J. F., Strachan, M. W., Reynolds, R. M., Tiemeier, H., Ripke, S., Mattheisen, M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. F., Bacanu, S-A., Bækvad-Hansen, M., Bennett, D. A., Berger, K., Bigdeli, T. B., Bybjerg-Grauholm, J., Byrne, E. M., Cai, N., Castelao, E., Clarke, T-K., Coleman, J. R., Consortium, C., Craddock, N., Dannlowski, U., Davies, G., Davies, G., de Geus, E. J. C., de Jager, P., Deary, I. J., Degenhardt, F., Dunn, E. C., Ehli, E. A., Eley, T. C., Escott-Price, V., Esko, T. N., Finucane, H. K., Gill, M., Gordon, S. D., Grove, J., Hall, L. S., Hansen, T. F., Søholm Hansen, C., Heath, A. C., Henders, A. K., Herms, S., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J-J., Hougaard, D., Huang, H., Ising, M., Jorgenson, E., Kloiber, S., Knowles, J. A., Kretzschmar, W. W., Krogh, J., Kutalik, Z., Lang, M., Lewis, G., Li, Y., MacIntyre, D. J., Madden, P. A., Marchine, J., Mbarek, H., McGuffin, P., Mehta, D., Metspalu, A., Middeldorp, C. M., Mihailov, E., Milani, L., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nordentoft, M., Nyholt, D. R., O'Donovan, M. C., O'Reilly, P. F., Oskarsson, H., Owen, M. J., Paciga, S. A., Pedersen, C. B. C., Pedersen, M. G., Pedersen, N. L., Pergadia, M. L., Peterson, R. E., Pettersson, E., Porteous, D. J., Potash, J. B., Quiroz, J. A., Rice, J. P., Riley, B. P., Rivera, M., Ruderfer, D. M., Saeed Mirza, S., Shen, L., Shi, J., Sigurdsson, E., Sinnamon, G. C., Smith, D. J., Stephansson, H., Steinberg, S., Strohmaier, J., Tansey, K. E., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Treutlein, J., Trzaskowski, M., Umbricht, D., van der Auwera, S., van Hemert, A. M., Viktorin, A., Völzke, H., Wang, Y., Webb, B. T., Weissman, M. M., Wellmann, J. R., Willemsen, G., Xi, H. S., Baune, B. T., Blackwood, D. H. R., Boomsma, D. I., Børglum, A. D., Buttenschøn, H. N., Cichon, S., Domenici, E., Flint, J., Grabe, H. J., Hamilton, S. P., Kendler, K. S., Li, Q. S., Lucae, S., Magnusson, P. K., McIntosh, A. M., Mors, O., Bo Mortensen, P., Müller-Myhsok, B., Perlis, R. H., Preisig, M., Schaefer, C., Smoller, J. W., Stephansson, K., Uher, R., Werge, T., Winslow, A. R., Breen, G., Levinson, D. F., Lewis, C. M., Wray, N. R., Sullivan, P. F., McGrath, J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N. A., Forstner, A. J., Schulze, T. G., Wüst, S., Nöthen, M. M., Baumgartner, M. R., Walker, B. R., Crawford, A. A., Colodro-Conde, L., Medland, S. E., Martin, N. G., Rietschel, M., (CORNET) Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), 1 Dec 2017, In: Scientific reports. 7, 1, 15351.

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    49 Citations (Scopus)

  • Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio

    Lin, B. D., Willemsen, G., Fedko, I. O., Jansen, R., Penninx, B. W. J. H., de Geus, E., Kluft, C., Hottenga, J. J. & Boomsma, D. I., 1 Apr 2017, In: Twin research and human genetics. 20, 2, p. 97-107 11 p.

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  • Identification of context-dependent expression quantitative trait loci in whole blood

    Zhernakova, D. V., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., van Dongen, J., & 28 othersHottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Zhernakova, A., Li, Y., Tigchelaar, E. F., de Klein, N., Beekman, M., Deelen, J., van Heemst, D., van den Berg, L. H., Hofman, A., Uitterlinden, A. G., Van Greevenbroek, M. J., Veldink, J. H., Boomsma, D. I., van Duijn, C. M., Wijmenga, C., Slagboom, P. E., Swertz, M. A., Isaacs, A., van Meurs, J. B. J., Jansen, R., Heijmans, B. T., ’t Hoen, P. A. C., Franke, L. & Hoen't, P. A. C., 1 Jan 2017, In: Nature Genetics. 49, 1, p. 139-145 7 p.

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  • Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

    Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Erzurumluoglu, A. M., O'Reilly, P. F., Cabrera, C. P., Warren, H. R., Rose, L. M., Verwoert, G. C., Hottenga, J-J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S-J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N., & 224 othersTeumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L-P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, J., Del Greco M, F., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemunik, T., Lu, Y., Evangelou, E., Shah, N., de Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G. R., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Beilby, J., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F. S., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., de Geus, E. J., de Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Farrall, M., Ferreira, T., Frånberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Hui, J., Jarvelin, M-R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K-T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A-P., Schmidt, R. E., Scott, R. J., Seelen, M. A., Shields, D. C., Siscovick, D., Sorice, R., Stanton, A., Stott, D. J., Sundström, J., Swertz, M. A., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., Attia, J. R., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., van der Harst, P., Palmer, C. N. A., Vergnaud, A-C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A. L., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J., Ehret, G. B. & Del Greco, F. M., 1 Sept 2017, In: Hypertension. 70, 3, p. e4-e19 16 p.

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  • Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

    23andMe Research Team, Schulz, H., Karrasch, S., Gieger, C., Strauch, K., Melles, R. B., Hinds, D. A., Hübner, N., Weidinger, S., Magnusson, P. K. E., Jansen, R., Jorgenson, E., Lee, Y. A., Almqvist, C., Karlsson, R., Koppelman, G. H. & Paternoster, L., 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1752-1757 6 p.

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  • 2016

    Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

    Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., Mei, H., van Galen, M., Deelen, P., Bonder, M. J., Zhernakova, A., Uitterlinden, A. G., Tigchelaar, E. F., Stehouwer, C. D. A., Schalkwijk, C. G., van der Kallen, C. J. H., Hofman, A., van Heemst, D., de Geus, E. J., van Dongen, J., & 14 othersDeelen, J., van den Berg, L. H., van Meurs, J., Jansen, R., 't Hoen, P. A. C., Franke, L., Wijmenga, C., Veldink, J. H., Swertz, M. A., van Greevenbroek, M. M. J., van Duijn, C. M., Boomsma, D. I., Slagboom, P. E. & Heijmans, B. T., 22 Sept 2016, In: Genome Biology. 17, 191, p. 1-13

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  • Blood lipids influence DNA methylation in circulating cells

    Dekkers, K. F., van Iterson, M., Slieker, R. C., Moed, M. H., Bonder, M. J., van Galen, M., Mei, H., Zhernakova, D. V., van den Berg, L. H., Deelen, J., van Dongen, J., van Heemst, D., Hofman, A., Hottenga, J. J., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Tigchelaar, E. F., Uitterlinden, A. G., Willemsen, G., & 14 othersZhernakova, A., Franke, L., 't Hoen, P. A. C., Jansen, R., van Meurs, J., Boomsma, D. I., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., van Zwet, E. W., Slagboom, P. E., Jukema, J. W. & Heijmans, B. T., 27 Jun 2016, In: Genome Biology. 17, 138, p. 1-12

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