Projects per year
Personal profile
Research interests
Pathophysiology and treatment of severe liver failure.
Development of a bioartificial liver charged with human liver cells able to support severe liver patients either to transplantation or recovery of the diseased liver.
Study of the mechanisms of liver regeneration and the influence of the bioartificial liver on it.
Development of a prognostic index to predict the course of acute liver failure.
Search for specific breathprints of exhaled air by eNose in patients with liver disease.
specialisation
Hepatology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Chamuleau R.A.F.M.: Development of a bioartificial liver therapy in acute liver failure (FP7 Health 2012 Innovation-2)
Chamuleau, R., Hoekstra, R., van der Mark, V., Abdelrahman Abubakr Adam, A. & van Wenum, M.
1/05/2013 → …
Project: Research
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Hoekstra R.: Bioartificial Liver
Hoekstra, R., van der Mark, V., Chamuleau, R., Abdelrahman Abubakr Adam, A. & van Wenum, M.
1/05/2013 → …
Project: Research
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Oude Elferink R.P.J.: Hepatic transport processes and Bioartificial Liver Support
Abdelrahman Abubakr Adam, A., Appelman, M., Bolier, A., Chang, J., Chen, H., van Dijk, R., Donkers, J., Folmer, D., Hohenester, S., Langedijk, J., van der Mark, V., Naik, J., van Niekerk, J., Roscam Abbing, R., Shi, X., Slijepcevic, D., van de Wiel, S., Oude Elferink, R., van de Graaf, S., Paulusma, C., de Waart, R., Hoekstra, R., Chamuleau, R., Duijst, S., Ho - Mok, K. S., Terlouw - Tolenaars, D. & de Jonge, H.
1/01/2006 → 1/03/2023
Project: Research
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End-stage liver failure: filling the treatment gap at the intensive care unit
Chamuleau, R. A. F. M. & Hoekstra, R., 1 Jun 2020, In: Journal of Artificial Organs. 23, 2, p. 113-123 11 p.Research output: Contribution to journal › Review article › Academic › peer-review
2 Citations (Scopus) -
Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR
Adam, A. A. A., Jongejan, A., Moerland, P. D., van der Mark, V. A., Oude Elferink, R. P., Chamuleau, R. A. F. M. & Hoekstra, R., 1 Jun 2020, In: Cytotechnology. 72, 3, p. 377-395 19 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells
van der Mark, V. A., Adam, A. A. A., Chang, J-C., Oude Elferink, R. P., Chamuleau, R. A. F. M. & Hoekstra, R., 15 Jul 2020, In: Toxicology and Applied Pharmacology. 399, 115055.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Overexpression of carbamoyl-phosphate synthase 1 significantly improves ureagenesis of human liver HepaRG cells only when cultured under shaking conditions
Adam, A. A. A., van der Mark, V. A., Ruiter, J. P. N., Wanders, R. J. A., Oude Elferink, R. P. J., Chamuleau, R. A. F. M. & Hoekstra, R., 2019, In: Mitochondrion. 47, p. 298-308Research output: Contribution to journal › Article › Academic › peer-review
3 Citations (Scopus) -
AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration
Adam, A. A. A., van Wenum, M., van der Mark, V. A., Jongejan, A., Moerland, P. D., Houtkooper, R. H., Wanders, R. J. A., Oude Elferink, R. P., Chamuleau, R. A. F. M. & Hoekstra, R., 2018, In: Mitochondrion. 39, p. 30-42Research output: Contribution to journal › Article › Academic › peer-review
10 Citations (Scopus)