Projects per year
Personal profile
Research interests
Rogier Sanders specialises in designing novel antiviral vaccines and antibodies. One of his major contributions was the development of stabilised HIV-1 envelope protein vaccines, which are now in clinical phase testing. In addition, this approach allowed for the first high-resolution structures of HIV-1 envelope protein trimers, which was hailed by Science as a scientific breakthrough in 2013 and fuelled structure-based HIV-1 vaccine design around the globe. Importantly, Rogier Sanders innovative proline-based stabilisation method was later used in the development of vaccines against RSV (respiratory syncytial virus), SARS-CoV, MERS-CoV, and recently SARS-CoV-2, the virus that causes COVID-19; indeed, Pfizer/BioNTech, Moderna, Novavax, and Janssen/Johnson & Johnson have all incorporated this method into their development of SARS-CoV-2 vaccines, and to date several hundreds of millions of people have received these vaccines, saving countless lives. His contribution to the rapid development of SARS-CoV-2 vaccines based on his seminal work with HIV-1 was acknowledged by Dr Anthony Fauci (Director of the National Institute of Allergy and Infectious Diseases and Chief Medical Advisor to the President of the United States) during a press conference at the White House in April 2021. Sanders provided a brief historical perspective in a mini-review.
Two additional applications of stabilised glycoprotein antigens are for sorting antigen-specific B cells and generating monoclonal antibodies. For example, an HIV-1 antibody co-discovered by Prof. Sanders is now in clinical testing for the prevention and treatment of HIV-1 infection. Moreover, Sanders co-discovered potently neutralizing SARS-CoV-2 antibodies. The general application is now used by countless labs around the world for a wide range of viruses.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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HIV vaccine research aimed at the induction of neutralizing antibodies
Brouwer, P., van Haaren, M., Del Moral Sanchez, I., Schorcht, A., de Taeye, S., Torrents de la Pena, A., Sanders, R., van Gils, M., Medina Ramirez, M., Bontjer, I., van Breemen, M. & Burger, J.
1/09/2010 → …
Project: Research
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Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
de Taeye, S. W., Ozorowski, G., Torrents de la Peña, A., Guttman, M., Julien, J-P., van den Kerkhof, T. L. G. M., Burger, J. A., Pritchard, L. K., Pugach, P., Yasmeen, A., Crampton, J., Hu, J., Bontjer, I., Torres, J. L., Arendt, H., DeStefano, J., Koff, W. C., Schuitemaker, H., Eggink, D., Berkhout, B., & 11 others , 2015, In: Cell. 163, 7, p. 1702-1715Research output: Contribution to journal › Article › Academic › peer-review
270 Citations (Scopus) -
HIV-1 neutralizing antibodies induced by native-like envelope trimers
Sanders, R. W., van Gils, M. J., Derking, R., Sok, D., Ketas, T. J., Burger, J. A., Ozorowski, G., Cupo, A., Simonich, C., Goo, L., Arendt, H., Kim, H. J., Lee, J. H., Pugach, P., Williams, M., Debnath, G., Moldt, B., van Breemen, M. J., Isik, G., Medina-Ramírez, M., & 17 others , 2015, In: Science. 349, 6244, p. aac4223-154Research output: Contribution to journal › Article › Academic › peer-review
412 Citations (Scopus) -
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability
van Gils, M. J., van den Kerkhof, T. L. G. M., Ozorowski, G., Cottrell, C. A., Sok, D., Pauthner, M., Pallesen, J., de Val, N., Yasmeen, A., de Taeye, S. W., Schorcht, A., Gumbs, S., Johanna, I., Saye-Francisco, K., Liang, C-H., Landais, E., Nie, X., Pritchard, L. K., Crispin, M., Kelsoe, G., & 7 others , 2016, In: Nature Microbiology. 2, 2, p. 16199Research output: Contribution to journal › Article › Academic › peer-review
114 Citations (Scopus) -
HIV: A stamp on the envelope
Sanders, R. W. & Moore, J. P., 2014, In: NATURE. 514, 7523, p. 437-438Research output: Contribution to journal › Editorial › Academic › peer-review
26 Citations (Scopus) -
A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice
Brinkkemper, M., Poniman, M., Siteur-van Rijnstra, E., Iddouch, W. A., Bijl, T. P. L., Guerra, D., Tejjani, K., Grobben, M., Bhoelan, F., Bemelman, D., Kempers, R., van Gils, M. J., Sliepen, K., Stegmann, T., van der Velden, Y. U. & Sanders, R. W., 17 May 2024, In: iScience. 27, 5, 109719.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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Crystal structure of the B41 SOSIP.664 Env trimer with PGT124 and 35O22 Fabs, in P63 space group
Kumar, S. (Contributor), Sarkar, A. (Contributor), Pugach, P. (Contributor), Sanders, R. (Contributor), Moore, J. P. (Contributor), Ward, A. B. (Contributor) & Wilson, I. A. (Contributor), Protein Data Bank (PDB), 27 Feb 2019
DOI: 10.2210/pdb6MDT, https://www.wwpdb.org/pdb?id=pdb_00006mdt
Dataset
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Crystal structure of human Fab CAP256-VRC26.04, a potent V1V2-directed HIV-1 neutralizing antibody
Doria-Rose, N. A. (Contributor), Schramm, C. A. (Contributor), Gorman, J. (Contributor), Moore, P. L. (Contributor), Bhiman, J. N. (Contributor), DeKosky, B. J. (Contributor), Ernandes, M. J. (Contributor), Georgiev, I. S. (Contributor), Kim, H. J. (Contributor), Pancera, M. (Contributor), Staupe, R. P. (Contributor), Altae-Tran, H. R. (Contributor), Bailer, R. T. (Contributor), Crooks, E. T. (Contributor), Cupo, A. (Contributor), Druz, A. (Contributor), Garrett, N. J. (Contributor), Hoi, K. H. (Contributor), Kong, R. (Contributor), Louder, M. K. (Contributor), Longo, N. S. (Contributor), McKee, K. (Contributor), Nonyane, M. (Contributor), O'Dell, S. (Contributor), Roark, R. S. (Contributor), Rudicell, R. S. (Contributor), Schmidt, S. D. (Contributor), Sheward, D. J. (Contributor), Soto, C. (Contributor), Wibmer, C. K. (Contributor), Yang, Y. (Contributor), Zhang, Z. (Contributor), Mullikin, J. C. (Contributor), Binley, J. M. (Contributor), Sanders, R. (Contributor), Wilson, I. A. (Contributor), Moore, J. P. (Contributor), Ward, A. B. (Contributor), Georgiou, G. (Contributor), Williamson, C. (Contributor), Karim, S. S. A. (Contributor), Morris, L. (Contributor), Kwong, P. D. (Contributor), Shapiro, L. (Contributor) & Mascola, J. R. (Contributor), Protein Data Bank (PDB), 26 Feb 2014
DOI: 10.2210/pdb4ORG, https://www.wwpdb.org/pdb?id=pdb_00004org
Dataset
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STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3
Saunders, K. O. (Contributor), Nicely, N. I. (Contributor), Wiehe, K. (Contributor), Bonsignori, M. (Contributor), Meyerhoff, R. R. (Contributor), Parks, R. (Contributor), Walkowicz, W. E. (Contributor), Aussedat, B. (Contributor), Wu, N. R. (Contributor), Cai, F. (Contributor), Vohra, Y. (Contributor), Park, P. K. (Contributor), Eaton, A. (Contributor), Go, E. P. (Contributor), Sutherland, L. L. (Contributor), Scearce, R. M. (Contributor), Barouch, D. H. (Contributor), Zhang, R. (Contributor), Von Holle, T. (Contributor), Overman, R. G. (Contributor), Anasti, K. (Contributor), Sanders, R. (Contributor), Moody, M. A. (Contributor), Kepler, T. B. (Contributor), Korber, B. (Contributor), Desaire, H. (Contributor), Santra, S. (Contributor), Letvin, N. L. (Contributor), Nabel, G. J. (Contributor), Montefiori, D. C. (Contributor), Tomaras, G. D. (Contributor), Liao, H. (Contributor), Alam, S. M. (Contributor), Danishefsky, S. J. (Contributor) & Haynes, B. F. (Contributor), Protein Data Bank (PDB), 1 Mar 2017
DOI: 10.2210/pdb5IIE, https://www.wwpdb.org/pdb?id=pdb_00005iie
Dataset
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AMC016 SOSIP.v4.2 in complex with PGV04 Fab
Schorcht, A. (Contributor), Cottrell, C. A. (Contributor), Pugach, P. (Contributor), Ringe, R. P. (Contributor), Han, A. X. (Contributor), Allen, J. D. (Contributor), van den Kerkhof, T. L. G. M. (Contributor), Seabright, G. E. (Contributor), Schermer, E. E. (Contributor), Ketas, T. J. (Contributor), Burger, J. (Contributor), van Schooten, J. (Contributor), LaBranche, C. C. (Contributor), Ozorowski, G. (Contributor), de Val, N. (Contributor), Bader, D. L. V. (Contributor), Schuitemaker, H. (Contributor), Russell, C. A. (Contributor), Montefiori, D. C. (Contributor), van Gils, M. (Contributor), Crispin, M. (Contributor), Klasse, P. J. (Contributor), Ward, A. B. (Contributor), Moore, J. P. (Contributor) & Sanders, R. (Contributor), Protein Data Bank (PDB), 15 Sept 2021
DOI: 10.2210/pdb7RSO, https://www.wwpdb.org/pdb?id=pdb_00007rso
Dataset
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ACS122 Fab
van Schooten, J. (Contributor), Schorcht, A. (Contributor), Farokhi, E. (Contributor), Umotoy, J. (Contributor), Gao, H. (Contributor), van den Kerkhof, T. L. G. M. (Contributor), Dorning, J. (Contributor), Rijkhold Meesters, T. G. (Contributor), van der Woude, P. (Contributor), Burger, J. (Contributor), Bijl, T. (Contributor), Ghalaiyini, R. (Contributor), de la Peña, A. T. (Contributor), Turner, H. L. (Contributor), Labranche, C. C. (Contributor), Stanfield, R. L. (Contributor), Sok, D. (Contributor), Schuitemaker, H. (Contributor), Montefiori, D. C. (Contributor), Burton, D. R. (Contributor), Ozorowski, G. (Contributor), Seaman, M. S. (Contributor), Wilson, I. A. (Contributor), Sanders, R. (Contributor), Ward, A. B. (Contributor) & van Gils, M. (Contributor), Protein Data Bank (PDB), 2 Nov 2022
DOI: 10.2210/pdb7U5G, https://www.wwpdb.org/pdb?id=pdb_00007u5g
Dataset
Press/Media
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Omnikon presenteert de rekening voor een zelfzuchtige vaccinatie koers
29/11/2021
1 Media contribution
Press/Media: Press / Media
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Nieuwe variant lijkt besmettelijker en minder gevoelig voor vaccins
27/11/2021
1 Media contribution
Press/Media: Press / Media
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