Projects per year
Personal profile
Research interests
Rogier Sanders specialises in designing novel antiviral vaccines and antibodies. One of his major contributions was the development of stabilised HIV-1 envelope protein vaccines, which are now in clinical phase testing. In addition, this approach allowed for the first high-resolution structures of HIV-1 envelope protein trimers, which was hailed by Science as a scientific breakthrough in 2013 and fuelled structure-based HIV-1 vaccine design around the globe. Importantly, Rogier Sanders innovative proline-based stabilisation method was later used in the development of vaccines against RSV (respiratory syncytial virus), SARS-CoV, MERS-CoV, and recently SARS-CoV-2, the virus that causes COVID-19; indeed, Pfizer/BioNTech, Moderna, Novavax, and Janssen/Johnson & Johnson have all incorporated this method into their development of SARS-CoV-2 vaccines, and to date several hundreds of millions of people have received these vaccines, saving countless lives. His contribution to the rapid development of SARS-CoV-2 vaccines based on his seminal work with HIV-1 was acknowledged by Dr Anthony Fauci (Director of the National Institute of Allergy and Infectious Diseases and Chief Medical Advisor to the President of the United States) during a press conference at the White House in April 2021. Sanders provided a brief historical perspective in a mini-review.
Two additional applications of stabilised glycoprotein antigens are for sorting antigen-specific B cells and generating monoclonal antibodies. For example, an HIV-1 antibody co-discovered by Prof. Sanders is now in clinical testing for the prevention and treatment of HIV-1 infection. Moreover, Sanders co-discovered potently neutralizing SARS-CoV-2 antibodies. The general application is now used by countless labs around the world for a wide range of viruses.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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HIV vaccine research aimed at the induction of neutralizing antibodies
Brouwer, P., van Haaren, M., Del Moral Sanchez, I., Schorcht, A., de Taeye, S., Torrents de la Pena, A., Sanders, R., van Gils, M., Medina Ramirez, M., Bontjer, I., van Breemen, M. & Burger, J.
1/09/2010 → …
Project: Research
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Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
de Taeye, S. W., Ozorowski, G., Torrents de la Peña, A., Guttman, M., Julien, J-P., van den Kerkhof, T. L. G. M., Burger, J. A., Pritchard, L. K., Pugach, P., Yasmeen, A., Crampton, J., Hu, J., Bontjer, I., Torres, J. L., Arendt, H., DeStefano, J., Koff, W. C., Schuitemaker, H., Eggink, D., Berkhout, B., & 11 others , 2015, In: Cell. 163, 7, p. 1702-1715Research output: Contribution to journal › Article › Academic › peer-review
264 Citations (Scopus) -
HIV-1 neutralizing antibodies induced by native-like envelope trimers
Sanders, R. W., van Gils, M. J., Derking, R., Sok, D., Ketas, T. J., Burger, J. A., Ozorowski, G., Cupo, A., Simonich, C., Goo, L., Arendt, H., Kim, H. J., Lee, J. H., Pugach, P., Williams, M., Debnath, G., Moldt, B., van Breemen, M. J., Isik, G., Medina-Ramírez, M., & 17 others , 2015, In: Science. 349, 6244, p. aac4223-154Research output: Contribution to journal › Article › Academic › peer-review
409 Citations (Scopus) -
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability
van Gils, M. J., van den Kerkhof, T. L. G. M., Ozorowski, G., Cottrell, C. A., Sok, D., Pauthner, M., Pallesen, J., de Val, N., Yasmeen, A., de Taeye, S. W., Schorcht, A., Gumbs, S., Johanna, I., Saye-Francisco, K., Liang, C-H., Landais, E., Nie, X., Pritchard, L. K., Crispin, M., Kelsoe, G., & 7 others , 2016, In: Nature Microbiology. 2, 2, p. 16199Research output: Contribution to journal › Article › Academic › peer-review
114 Citations (Scopus) -
HIV: A stamp on the envelope
Sanders, R. W. & Moore, J. P., 2014, In: NATURE. 514, 7523, p. 437-438Research output: Contribution to journal › Editorial › Academic › peer-review
26 Citations (Scopus) -
A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection
Ronk, A. J., Lloyd, N. M., Zhang, M., Atyeo, C., Perrett, H. R., Mire, C. E., Hastie, K. M., Sanders, R. W., Brouwer, P. J. M., Saphire, E. O., Ward, A. B., Ksiazek, T. G., Alvarez Moreno, J. C., Thaker, H. M., Alter, G., Himansu, S., Carfi, A. & Bukreyev, A., 1 Dec 2023, In: Nature communications. 14, 1, 5603.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus)
Datasets
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BG505 SOSIP.v5.2 N241/N289 in complex with the polyclonal Fab pAbC-4 from animal Rh.33311 (Wk26 time point)
Antanasijevic, A. (Contributor), Sewall, L. M. (Contributor), Cottrell, C. A. (Contributor), Carnathan, D. G. (Contributor), Jimenez, L. E. (Contributor), Ngo, J. T. (Contributor), Silverman, J. B. (Contributor), Groschel, B. (Contributor), Georgeson, E. (Contributor), Bhiman, J. (Contributor), Bastidas, R. (Contributor), LaBranche, C. (Contributor), Allen, J. D. (Contributor), Copps, J. (Contributor), Perrett, H. R. (Contributor), Rantalainen, K. (Contributor), Cannac, F. (Contributor), Yang, Y. R. (Contributor), de la Peña, A. T. (Contributor), Rocha, R. F. (Contributor), Berndsen, Z. T. (Contributor), Baker, D. (Contributor), King, N. P. (Contributor), Sanders, R. (Contributor), Moore, J. P. (Contributor), Crotty, S. (Contributor), Crispin, M. (Contributor), Montefiori, D. C. (Contributor), Burton, D. R. (Contributor), Schief, W. R. (Contributor), Silvestri, G. (Contributor) & Ward, A. B. (Contributor), Protein Data Bank (PDB), 4 Aug 2021
DOI: 10.2210/pdb7L8X, https://www.wwpdb.org/pdb?id=pdb_00007l8x
Dataset
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BG505 SOSIP MD39 in complex with the polyclonal Fab pAbC-3 from animal Rh.32034 (Wk26 time point)
Antanasijevic, A. (Contributor), Sewall, L. M. (Contributor), Cottrell, C. A. (Contributor), Carnathan, D. G. (Contributor), Jimenez, L. E. (Contributor), Ngo, J. T. (Contributor), Silverman, J. B. (Contributor), Groschel, B. (Contributor), Georgeson, E. (Contributor), Bhiman, J. (Contributor), Bastidas, R. (Contributor), LaBranche, C. (Contributor), Allen, J. D. (Contributor), Copps, J. (Contributor), Perrett, H. R. (Contributor), Rantalainen, K. (Contributor), Cannac, F. (Contributor), Yang, Y. R. (Contributor), de la Peña, A. T. (Contributor), Rocha, R. F. (Contributor), Berndsen, Z. T. (Contributor), Baker, D. (Contributor), King, N. P. (Contributor), Sanders, R. (Contributor), Moore, J. P. (Contributor), Crotty, S. (Contributor), Crispin, M. (Contributor), Montefiori, D. C. (Contributor), Burton, D. R. (Contributor), Schief, W. R. (Contributor), Silvestri, G. (Contributor) & Ward, A. B. (Contributor), Protein Data Bank (PDB), 4 Aug 2021
DOI: 10.2210/pdb7L88, https://www.wwpdb.org/pdb?id=pdb_00007l88
Dataset
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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-04
Wu, N. C. (Contributor), Yuan, M. (Contributor), Liu, H. (Contributor), Lee, C. D. (Contributor), Zhu, X. (Contributor), Bangaru, S. (Contributor), Torres, J. L. (Contributor), Caniels, T. (Contributor), Brouwer, P. J. M. (Contributor), van Gils, M. (Contributor), Sanders, R. (Contributor), Ward, A. B. (Contributor) & Wilson, I. A. (Contributor), Protein Data Bank (PDB), 26 Aug 2020
DOI: 10.2210/pdb7JMO, https://www.wwpdb.org/pdb?id=pdb_00007jmo
Dataset
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Crystal Structure of Fab 32H+109L, a putative precursor of the PGT121 family of potent HIV-1 antibodies
Garces, F. (Contributor), Lee, J. H. (Contributor), de Val, N. (Contributor), Torrents de la Pena, A. (Contributor), Kong, L. (Contributor), Puchades, C. (Contributor), Hua, Y. (Contributor), Stanfield, R. L. (Contributor), Burton, D. R. (Contributor), Moore, J. P. (Contributor), Sanders, R. (Contributor), Ward, A. B. (Contributor) & Wilson, I. A. (Contributor), Protein Data Bank (PDB), 23 Dec 2015
DOI: 10.2210/pdb5CEX, https://www.wwpdb.org/pdb?id=pdb_00005cex
Dataset
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BG505 SOSIP MD39 in complex with the polyclonal Fab pAbC-3 from animal Rh.33104 (Wk26 time point)
Antanasijevic, A. (Contributor), Sewall, L. M. (Contributor), Cottrell, C. A. (Contributor), Carnathan, D. G. (Contributor), Jimenez, L. E. (Contributor), Ngo, J. T. (Contributor), Silverman, J. B. (Contributor), Groschel, B. (Contributor), Georgeson, E. (Contributor), Bhiman, J. (Contributor), Bastidas, R. (Contributor), LaBranche, C. (Contributor), Allen, J. D. (Contributor), Copps, J. (Contributor), Perrett, H. R. (Contributor), Rantalainen, K. (Contributor), Cannac, F. (Contributor), Yang, Y. R. (Contributor), de la Peña, A. T. (Contributor), Rocha, R. F. (Contributor), Berndsen, Z. T. (Contributor), Baker, D. (Contributor), King, N. P. (Contributor), Sanders, R. (Contributor), Moore, J. P. (Contributor), Crotty, S. (Contributor), Crispin, M. (Contributor), Montefiori, D. C. (Contributor), Burton, D. R. (Contributor), Schief, W. R. (Contributor), Silvestri, G. (Contributor) & Ward, A. B. (Contributor), Protein Data Bank (PDB), 4 Aug 2021
DOI: 10.2210/pdb7L8C, https://www.wwpdb.org/pdb?id=pdb_00007l8c
Dataset
Press/Media
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Omnikon presenteert de rekening voor een zelfzuchtige vaccinatie koers
29/11/2021
1 Media contribution
Press/Media: Press / Media
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Nieuwe variant lijkt besmettelijker en minder gevoelig voor vaccins
27/11/2021
1 Media contribution
Press/Media: Press / Media
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