Projects per year
My research interest is focussed on improving outcomes and quality of life in patients with oesophageal adenocarcinoma, and to prevent patients from developing oesophageal adenocarcinoma. For this, I run the following research lines:
1. Improving management of patients with early oesophageal adenocarcinoma.
As interventional endoscopist I am constantly trying to find less invasive, more effective and safer methods to treat patients with early stages of oesophageal adenocarcinoma and precursor lesions. This ranges from studying new endoscopic techniques or devices, to evaluating new management strategies. By improving and expanding the endoscopic arsenal and by optimizing follow-up strategies in patients treated for oesophageal adenocarcinoma, I hope we can treat more patients endoscopically, and prevent unnessecary and more invasive therapy such as surgery.
2. Identification and validation of biomarkers, for risk stratification of patients with Barrett's oesophagus.
Barrett's oesophagus is the most important risk factor for oesophageal adenocarcinoma. Patients therefore undergo regular endoscopic surveillance with biopsies. However, this is not a cost-effective approach and endoscopies can be a great burden to patients. Using a large tissue bank with samples from patients surveyed for Barrett's oesophagus who did or did not progress to cancer, I try to find biomarkers that can be used to identify patients with increased risk for cancer who may benefit from prophylactic treatment. Patients with a very low risk of progressing to cancer may be reassured and may not require further surveillance.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Dept. of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands
Oct 2012 → Aug 2017
Award Date: 10 Aug 2017
PhD, University of Amsterdam, Amsterdam, Netherlands
1 Nov 2006 → 1 Nov 2010
Award Date: 10 Nov 2011
Master, Faculty of Medicine, University of Utrecht, Utrecht, the Netherlands
Award Date: 20 Sep 2006
- R Medicine (General)
- Barrett's oesophagus
- early neoplasia
- endoscopic resection
- endoscopic ablation
Dive into details
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- 1 Active
Bergman, J., Pouw, R., van Baar, A. C. G., Belghazi, K., Bureo Gonzalez, A., Duits, L. C., de Groof, J. J., Klaver, E., Kunzli, H. T., van Munster, S. N., Rosmolen, W. D., Scholvinck, D. W., Swager, A., van der Wel, M. J. & Stingl, C.
1/01/2006 → …
Simplified versus standard regimen for focal radiofrequency ablation of dysplastic Barrett's oesophagus: a multicentre randomised controlled trialPouw, R. E., Künzli, H. T., Bisschops, R., Sondermeijer, C. M., Koch, A. D., Didden, P., Gotink, A. W., Schoon, E. J., Curvers, W. L., Bergman, J. J. G. H. M. & Weusten, B. L. A. M., Aug 2018, In: The Lancet Gastroenterology and Hepatology. 3, 8, p. 566-574 9 p.
Research output: Contribution to Journal › Article › Academic › peer-review17 Citations (Scopus)
Long-term follow-up results of stepwise radical endoscopic resection for Barrett's esophagus with early neoplasiaBelghazi, K., van Vilsteren, F. G. I., Weusten, B. L. A. M., Meijer, S. L., Bergman, J. J. G. H. M. & Pouw, R. E., Jan 2018, In: Gastrointestinal endoscopy. 87, 1, p. 77-84 8 p.
Research output: Contribution to Journal › Article › Academic › peer-review16 Citations (Scopus)
A prospective multicenter study using a new multiband mucosectomy device for endoscopic resection of early neoplasia in Barrett's esophagusPouw, R. E., Beyna, T., Belghazi, K., Koch, A. D., Schoon, E. J., Haidry, R., Weusten, B. L., Bisschops, R., Shaheen, N. J., Wallace, M. B., Marcon, N., Heise-Ginsburg, R., Gotink, A. W., Wang, K. K., Leggett, C. L., Ortiz-Fernández-Sordo, J., Ragunath, K., DiPietro, M., Pech, O., Neuhaus, H., & 1 others, Oct 2018, In: Gastrointestinal endoscopy. 88, 4, p. 647-654 8 p.
Research output: Contribution to journal › Article › Academic › peer-review12 Citations (Scopus)
Risk factors for serious adverse events associated with multiband mucosectomy in Barrett's esophagus: an international multicenter analysis of 3827 endoscopic resection procedures: an international multicenter analysis of 3827 endoscopic resection proceduresBelghazi, K., Marcon, N., Teshima, C., Wang, K. K., Milano, R. V., Mostafavi, N., Wallace, M. B., Kandel, P., Mejía Pérez, L. K., Bourke, M. J., Bahin, F., Everson, M. A., Haidry, R., Ginsberg, G. G., Ma, G. K., Koch, A. D., Ragunath, K., Ortiz-Fernandez-Sordo, J., di Pietro, M., Seewald, S., & 5 others, Aug 2020, In: Gastrointestinal endoscopy. 92, 2, p. 259-268.e2
Research output: Contribution to Journal › Article › Academic › peer-reviewOpen Access6 Citations (Scopus)
The Amsterdam ReBus progressor cohort: identification of 165 Barrett's surveillance patients who progressed to early neoplasia and 723 nonprogressor patientsDuits, L. C., Klaver, E., Bureo Gonzalez, A., Boerwinkel, D. F., Ten Kate, F. J. W., Offerhaus, G. J. A., Meijer, S. L., Visser, M., Seldenrijk, C. A., Krishnadath, K. K., Schoon, E. J., Weusten, B. L. A. M., Mallant-Hent, R. C., Pouw, R. E. & Bergman, J. J. G. H. M., 13 Nov 2019, In: Diseases of the esophagus. 32, 9
Research output: Contribution to Journal › Article › Academic › peer-review3 Citations (Scopus)
- 2 Membership of guidelines
Roos Pouw (Member)1 Nov 2022
Activity: Membership › Membership of guidelines
Roos Pouw (Chair)29 Jun 2020
Activity: Membership › Membership of guidelines