Projects per year
Personal profile
Research interests
The plasma membrane of hepatocytes harbors several drug extrusion pumps, such as MRP2 (ABCC2), ABCG2 and MDR1 (ABCB1) in the canalicular membrane and MRP3 (ABCC3) and MRP4 (ABCC4) in the basolateral membrane. These ATP-dependent transporters are expressed both in liver and in the intestine; therefore they determine to a large extent the pharmacokinetic behaviour of drugs. In mouse strains with disruptions of the various transporter genes (as well as combined gene disruptions) we determine the role of these transporters in pharmacokinetics of various classes of drugs. These issues will become increasingly important for drug development as well as the elucidation of drug-drug interactions.
specialisation
transport of drugs and compounds mediated by multidrug resistant associated proteins
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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van de Graaf K.F.J. (Stan): metabolite dynamics and liver-centered organ crosstalk
van de Graaf, S., Appelman, M., Chen, H., Donkers, J., Hubers, L., van Niekerk, J., Roscam Abbing, R., Slijepcevic, D., van de Wiel, S., Oude Elferink, R., de Waart, R., Paulusma, C., Duijst, S., Beuers, U., Bolt, I., Vogels, E., In het Panhuis, W., Kunst, R., Wu, D., Trampert, D. C., Kersten, R., Groenen, C. & Nguyen, T.
1/06/2016 → …
Project: Research
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Oude Elferink R.P.J.: Hepatic transport processes and Bioartificial Liver Support
Abdelrahman Abubakr Adam, A., Appelman, M., Bolier, A., Chang, J., Chen, H., van Dijk, R., Donkers, J., Folmer, D., Hohenester, S., Langedijk, J., van der Mark, V., Naik, J., van Niekerk, J., Roscam Abbing, R., Shi, X., Slijepcevic, D., van de Wiel, S., Oude Elferink, R., van de Graaf, S., Paulusma, C., de Waart, R., Hoekstra, R., Chamuleau, R., Duijst, S., Ho - Mok, K. S., Terlouw - Tolenaars, D. & de Jonge, H.
1/01/2006 → 1/03/2023
Project: Research
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Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs
Li, W., Iusuf, D., Sparidans, R. W., Wagenaar, E., Wang, Y., de Waart, D. R., Martins, M. L. F., van Hoppe, S., Lebre, M. C., van Tellingen, O., Beijnen, J. H. & Schinkel, A. H., 1 Apr 2023, In: Pharmacological Research. 190, 106724.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Differential and organ-specific functions of organic solute transporter α and β in experimental cholestasis
van de Wiel, S. M. W., Porteiro, B., Belt, S. C., Vogels, E. W. M., Bolt, I., Vermeulen, J. L. M., de Waart, D. R., Verheij, J., Muncan, V., Oude Elferink, R. P. J. & van de Graaf, S. F. J., 1 May 2022, In: JHEP Reports. 4, 5, p. 100463 100463.Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus) -
Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice
Kunst, R. F., de Waart, D. R., Wolters, F., Duijst, S., Vogels, E. W., Bolt, I., Verheij, J., Beuers, U., Oude Elferink, R. P. J. & van de Graaf, S. F. J., 1 Nov 2022, In: JHEP Reports. 4, 11, 100573.Research output: Contribution to journal › Article › Academic › peer-review
Open Access6 Citations (Scopus) -
Collagen release by human hepatic stellate cells requires vitamin C and is efficiently blocked by hydroxylase inhibition
Smith-Cortinez, N., Fagundes, R. R., Gomez, V., Kong, D., de Waart, D. R., Heegsma, J., Sydor, S., Olinga, P., de Meijer, V. E., Taylor, C. T., Bank, R., Paulusma, C. C. & Faber, K. N., Feb 2021, In: FASEB Journal. 35, 2, p. e21219 e21219.Research output: Contribution to journal › Article › Academic › peer-review
Open Access9 Citations (Scopus) -
Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients
Shi, X., Aronson, S. J., ten Bloemendaal, L., Duijst, S., Bakker, R. S., de Waart, D. R., Bortolussi, G., Collaud, F., Oude Elferink, R. P., Muro, A. F., Mingozzi, F., Ronzitti, G. & Bosma, P. J., 12 Mar 2021, In: Molecular therapy. Methods & clinical development. 20, p. 287-297 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus)