Projects per year
Personal profile
Research interests
Throughout my career, I pursued a clear line of research that focused on understanding why people make unfortunate decisions and display harmful behaviours, and importantly, why don’t they stop?! My Ph.D. elucidated specific neurobiological characteristics of pathological gambling and its similarities and differences with alcohol dependence. Directly after obtaining my Ph.D. I received an ECNP Research Grant, enabling me to focus on the neural correlates of risky decision-making at the University of Cambridge. With my NWO Rubicon fellowship grant, I focused on elucidating the role of dopamine in pathological gambling using PET scans at the Donders Institute.
Since dysfunctional decision-making and dopamine functioning underlie more psychiatric disorders than pathological gambling alone, I am intrigued to find the common denominator across psychiatric disorders. Therefore, I expanded my research to also include game addiction, obsessive-compulsive disorder, and obesity, for which I collaborated with different international research groups. To better understand food-related motivational processes I currently collaborate on a translational study using optogenetics in mice.
With a personal ABC-talent grant in 2014, I moved to the AMC to study the neural fundaments of confidence estimation in compulsive behaviour and be co-promotor of two Ph.D. students investigating habitual behaviour and the effect of non-invasive brain stimulation in addiction. In the coming years, I will use a variety of neuroimaging techniques (fMRI/PET), brain-activity modulators (rTMS/pharmaca) and approaches (network/DSM/transdiagnostic) to psychiatry with the aim to contribute to the understanding of the neural fundamentals of psychiatric disorders, especially of disorders in which people display faulty decision-making.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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What makes them Tick? Characteristics of youth that gamble, the prevalence and possible gateways to (harmful) gambling
1/02/2024 → 1/02/2026
Project: Research
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Goudriaan A.E.: Neurobiological mechanisms of action and treatment effects in addictive disorders
Goudriaan, A., van Holst, R., Schluter, R., Schulte, M., van Timmeren, T., de Waal, M., Bakelaar, S., Beraha Menahem, E., Boog, M. & Lommerse, N.
1/12/2011 → …
Project: Research
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DOPACON: The role of dopamine in confidence and gambling disorder
1/01/2021 → 8/02/2024
Project: Research
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Developing a network theory of addiction and depression in an urban population
van Holst, R., Huth, K. & Luigjes, J.
1/04/2020 → 31/03/2024
Project: Research
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Attention, confidence and risky decisions in gambling disorder
1/01/2020 → 31/05/2023
Project: Research
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Are There Differences in Disruptions of Reward Processing Between Substance Use Disorder and Gambling Disorder?
van Holst, R. J., van Timmeren, T. & Goudriaan, A. E., Jul 2017, In: JAMA Psychiatry. 74, 7, p. 759-760 2 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
2 Citations (Scopus) -
Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation
Sescousse, G., Ligneul, R., van Holst, R. J., Janssen, L. K., de Boer, F., Janssen, M., Berry, A. S., Jagust, W. J. & Cools, R., 2018, In: European Journal of Neuroscience. 47, 9, p. 1081-1086Research output: Contribution to journal › Article › Academic › peer-review
Open Access50 Citations (Scopus) -
Two sides of the same coin: Monetary incentives concurrently improve and bias confidence judgments
Lebreton, M., Langdon, S., Slieker, M. J., Nooitgedacht, J. S., Goudriaan, A. E., Denys, D., van Holst, R. J. & Luigjes, J., 2018, In: Science advances. 4, 5, eaaq066.Research output: Contribution to journal › Article › Academic › peer-review
Open Access33 Citations (Scopus) -
Compulsivity-related neurocognitive performance deficits in gambling disorder: A systematic review and meta-analysis
van Timmeren, T., Daams, J. G., van Holst, R. J. & Goudriaan, A. E., Jan 2018, In: Neuroscience and Biobehavioral Reviews. 84, p. 204-217 14 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access81 Citations (Scopus) -
Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction
van Holst, R. J., Sescousse, G., Janssen, L. K., Janssen, M., Berry, A. S., Jagust, W. J. & Cools, R., 2018, In: Biological Psychiatry. 83, 12, p. 1036-1043Research output: Contribution to journal › Article › Academic › peer-review
47 Citations (Scopus)
Datasets
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Codes and Data - Lebreton et al. Science Advances 2018
Lebreton, M. (Creator), Langdon, S. (Creator), Slieker, M. J. (Creator), Nooitgedacht, J. S. (Creator), Goudriaan, A. (Contributor), Denys, D. (Creator), van Holst, R. (Contributor) & Luigjes, J. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.6126776.v3, https://figshare.com/articles/dataset/Codes_and_Data/6126776/3
Dataset
Prizes
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Doorbraakronde: Preventie van Kansspelverslaving
van Holst, Ruth (Recipient), Oct 2023
Prize: Other prizes and awards › Academic
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Main organizer of the Current Advances in Gambling Research conference 2024
Ruth van Holst (Participant)
19 Jun 2024 → 21 Jun 2024Activity: Participating in or organising an event › Participation in conference › Academic
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Metacognition and compulsive behaviour
Ruth van Holst (Speaker)
6 Mar 2024Activity: Lecture / Presentation › Invited talk › Academic
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Een kijkje in de hersenen: wat we weten over gokverslaving
Ruth van Holst (Speaker)
7 Sept 2023Activity: Lecture / Presentation › Invited talk › Professional
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University of Amsterdam (External organisation)
Ruth van Holst (Chair)
Mar 2023Activity: Membership › Membership of committee › Academic
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PLOS Mental Health (Journal)
Ruth van Holst (Member of editorial board)
Oct 2023Activity: Peer review and Editorial work › Editorial activity
Press/Media
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BOOS: Hoe de goklobby jouw leven kan verwoesten
7/12/2023
1 Media contribution
Press/Media: Press / Media
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