Sander van Hooff

Research output

Research output per year 2008 2021 2024

• 26 Article
• 1 Review article

Research output per year

Research output per year

Search results

• 2024

  Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

  Wienke, J., Visser, L. L., Kholosy, W. M., Keller, K. M., Barisa, M., Poon, E., Munnings-Tomes, S., Himsworth, C., Calton, E., Rodriguez, A., Bernardi, R., van den Ham, F., van Hooff, S. R., Matser, Y. A. H., Tas, M. L., Langenberg, K. P. S., Lijnzaad, P., Borst, A. L., Zappa, E., Bergsma, F. J., & 28 othersStrijker, J. G. M., Verhoeven, B. M., Mei, S., Kramdi, A., Restuadi, R., Sanchez-Bernabeu, A., Cornel, A. M., Holstege, F. C. P., Gray, J. C., Tytgat, G. A. M., Scheijde-Vermeulen, M. A., Wijnen, M. H. W. A., Dierselhuis, M. P., Straathof, K., Behjati, S., Wu, W., Heck, A. J. R., Koster, J., Nierkens, S., Janoueix-Lerosey, I., de Krijger, R. R., Baryawno, N., Chesler, L., Anderson, J., Caron, H. N., Margaritis, T., van Noesel, M. M. & Molenaar, J. J., 12 Feb 2024, In: Cancer cell. 42, 2, p. 283-300.e8

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2023

  Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes

  Cobos, F. A., Panah, M. J. N., Epps, J., Long, X., Man, T-K., Chiu, H-S., Chomsky, E., Kiner, E., Krueger, M. J., di Bernardo, D., Voloch, L., Molenaar, J., van Hooff, S. R., Westermann, F., Jansky, S., Redell, M. L., Mestdagh, P. & Sumazin, P., 1 Dec 2023, In: Genome Biology. 24, 1, 177.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The potential of PARP as a therapeutic target across pediatric solid malignancies

  Keller, K. M., Koetsier, J., Schild, L., Amo-Addae, V., Eising, S., van den Handel, K., Ober, K., Koopmans, B., Essing, A., van den Boogaard, M. L., Langenberg, K. P. S., Jäger, N., Kool, M., Pfister, S., Dolman, M. E. M., Molenaar, J. J. & van Hooff, S. R., 1 Dec 2023, In: BMC Cancer. 23, 1, 310.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Two opposing gene expression patterns within ATRX aberrant neuroblastoma

  van Gerven, M. R., Schild, L., van Arkel, J., Koopmans, B., Broeils, L. A., Meijs, L. A. M., van Oosterhout, R., van Noesel, M. M., Koster, J., van Hooff, S. R., Molenaar, J. J. & van den Boogaard, M. L., Aug 2023, In: PLOS ONE. 18, 8 AUGUST, p. e0289084 e0289084.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2022

  Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

  Keller, K. M., Eleveld, T. F., Schild, L., van den Handel, K., van den Boogaard, M., Amo-Addae, V., Eising, S., Ober, K., Koopmans, B., Looijenga, L., Tytgat, G. A. M., Ylstra, B., Molenaar, J. J., Dolman, M. E. M. & van Hooff, S. R., 27 Sept 2022, In: Frontiers in Oncology. 12, 929123.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’

  Langenberg, K. P. S., Meister, M. T., Bakhuizen, J. J., Boer, J. M., van Eijkelenburg, N. K. A., Hulleman, E., Ilan, U., Looze, E. J., Dierselhuis, M. P., van der Lugt, J., Breunis, W., Schild, L. G., Ober, K., van Hooff, S. R., Scheijde-Vermeulen, M. A., Hiemcke-Jiwa, L. S., Flucke, U. E., Kranendonk, M. E. G., Wesseling, P., Sonneveld, E., & 34 othersPunt, S., Boltjes, A., van Dijk, F., Verwiel, E. T. P., Volckmann, R., Hehir-Kwa, J. Y., Kester, L. A., Koudijs, M. M. J., Waanders, E., Holstege, F. C. P., Vormoor, H. J., Hoving, E. W., van Noesel, M. M., Pieters, R., Kool, M., Stumpf, M., Blattner-Johnson, M., Balasubramanian, G. P., van Tilburg, C. M., Jones, B. C., Jones, D. T. W., Witt, O., Pfister, S. M., Jongmans, M. C. J., Kuiper, R. P., de Krijger, R. R., Wijnen, M. H. W., den Boer, M. L., Zwaan, C. M., Kemmeren, P., Koster, J., Tops, B. B. J., Goemans, B. F. & Molenaar, J. J., 1 Nov 2022, In: European Journal of Cancer. 175, p. 311-325 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  13 Citations (Scopus)

• Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for paediatric solid malignancies

  Keller, K. M., Krausert, S., Gopisetty, A., Luedtke, D., Koster, J., Schubert, N. A., Rodríguez, A., van Hooff, S. R., Stichel, D., Dolman, M. E. M., Vassal, G., Pfister, S. M., Caron, H. N., Stancato, L. F., Molenaar, J. J., Jäger, N. & Kool, M., 1 Feb 2022, In: European Journal of Cancer. 162, p. 107-117 11 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  7 Citations (Scopus)
• 2021

  Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

  di Franco, S., Bianca, P., Sardina, D. S., Turdo, A., Gaggianesi, M., Veschi, V., Nicotra, A., Mangiapane, L. R., Lo Iacono, M., Pillitteri, I., van Hooff, S., Martorana, F., Motta, G., Gulotta, E., Lentini, V. L., Martorana, E., Fiori, M. E., Vieni, S., Bongiorno, M. R., Giannone, G., & 9 othersGiuffrida, D., Memeo, L., Colarossi, L., Mare, M., Vigneri, P., Todaro, M., de Maria, R., Medema, J. P. & Stassi, G., 1 Dec 2021, In: Nature communications. 12, 1, 5006.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  38 Citations (Scopus)

• AKT3 expression in mesenchymal colorectal cancer cells drives growth and is associated with epithelial-mesenchymal transition

  Buikhuisen, J. Y., Barila, P. M. G., Torang, A., Dekker, D., de Jong, J. H., Cameron, K., Vitale, S., Stassi, G., van Hooff, S. R., Castro, M. A. A., Vermeulen, L. & Medema, J. P., 2 Feb 2021, In: Cancers. 13, 4, p. 1-19 19 p., 801.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  16 Citations (Scopus)

• BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer

  Ramesh, P., Lannagan, T. R. M., Jackstadt, R., Atencia Taboada, L., Lansu, N., Wirapati, P., van Hooff, S. R., Dekker, D., Pritchard, J., Kirov, A. B., van Neerven, S. M., Tejpar, S., Kops, G. J. P. L., Sansom, O. J. & Medema, J. P., Dec 2021, In: Cell death and differentiation. 28, 12, p. 3282-3296 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  25 Citations (Scopus)

• Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

  S:CORT consortium, 1 Dec 2021, In: Nature communications. 12, 1, 3464.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  28 Citations (Scopus)

• Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

  Calandrini, C., van Hooff, S. R., Paassen, I., Ayyildiz, D., Derakhshan, S., Dolman, M. E. M., Langenberg, K. P. S., van de Ven, M., de Heus, C., Liv, N., Kool, M., de Krijger, R. R., Tytgat, G. A. M., van den Heuvel-Eibrink, M. M., Molenaar, J. J. & Drost, J., 24 Aug 2021, In: Cell reports. 36, 8, 109568.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  17 Citations (Scopus)

• Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

  Kildisiute, G., Kholosy, W. M., Young, M. D., Roberts, K., Elmentaite, R., van Hooff, S. R., Pacyna, C. N., Khabirova, E., Piapi, A., Thevanesan, C., Bugallo-Blanco, E., Burke, C., Mamanova, L., Keller, K. M., Langenberg-Ververgaert, K. P. S., Lijnzaad, P., Margaritis, T., Holstege, F. C. P., Tas, M. L., Wijnen, M. H. W. A., & 19 othersvan Noesel, M. M., del Valle, I., Barone, G., van der Linden, R., Duncan, C., Anderson, J., Achermann, J. C., Haniffa, M., Teichmann, S. A., Rampling, D., Sebire, N. J., He, X., de Krijger, R. R., Barker, R. A., Meyer, K. B., Bayraktar, O., Straathof, K., Molenaar, J. J. & Behjati, S., 5 Feb 2021, In: Science advances. 7, 6, eabd3311.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  61 Citations (Scopus)

• αβ-T Cells Engineered to Express γδ-T Cell Receptors Can Kill Neuroblastoma Organoids Independent of MHC-I Expression

  Strijker, J. G. M., Pscheid, R., Drent, E., van der Hoek, J. J. F., Koopmans, B., Ober, K., van Hooff, S. R., Kholosy, W. M., Cornel, A. M., Coomans, C., Bisso, A., van Loenen, M. M., Molenaar, J. J. & Wienke, J., 1 Sept 2021, In: Journal of personalized medicine. 11, 9, 923.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)
• 2020

  Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems

  Dijk, F., Veenstra, V. L., Soer, E. C., Dings, M. P. G., Zhao, L., Halfwerk, J. B., Hooijer, G. K., Damhofer, H., Marzano, M., Steins, A., Waasdorp, C., Busch, O. R., Besselink, M. G., Tol, J. A., Welling, L., van Rijssen, L. B., Klompmaker, S., Wilmink, H. W., van Laarhoven, H. W., Medema, J. P., & 7 othersVermeulen, L., van Hooff, S. R., Koster, J., Verheij, J., van de Vijver, M. J., Wang, X. & Bijlsma, M. F., 1 Dec 2020, In: Scientific reports. 10, 1, p. 337 337.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  42 Citations (Scopus)
• 2019

  Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models

  Prasetyanti, P. R., van Hooff, S. R., van Herwaarden, T., de Vries, N., Kalloe, K., Rodermond, H., van Leersum, R., de Jong, J. H., Franitza, M., Nürnberg, P., Todaro, M., Stassi, G. & Medema, J. P., 2019, In: International journal of cancer. Journal international du cancer. 144, 2, p. 366-371

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  31 Citations (Scopus)

• Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

  Jackstadt, R., van Hooff, S. R., Leach, J. D., Cortes-Lavaud, X., Lohuis, J. O., Ridgway, R. A., Wouters, V. M., Roper, J., Kendall, T. J., Roxburgh, C. S., Horgan, P. G., Nixon, C., Nourse, C., Gunzer, M., Clark, W., Hedley, A., Yilmaz, O. H., Rashid, M., Bailey, P., Biankin, A. V., & 6 othersCampbell, A. D., Adams, D. J., Barry, S. T., Steele, C. W., Medema, J. P. & Sansom, O. J., 2019, In: Cancer cell. 36, 3, p. 319-336.e7

  Research output: Contribution to journal › Article › Academic › peer-review
  242 Citations (Scopus)
• 2018

  Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

  Linnekamp, J. F., van Hooff, S. R., Prasetyanti, P. R., Kandimalla, R., Buikhuisen, J. Y., Fessler, E., Ramesh, P., Lee, K. A. S. T., Bochove, G. G. W., de Jong, J. H., Cameron, K., van Leersum, R., Rodermond, H. M., Franitza, M., Nürnberg, P., Mangiapane, L. R., Wang, X., Clevers, H., Vermeulen, L., Stassi, G., & 1 othersMedema, J. P., 2018, In: Cell death and differentiation. 25, p. 616-633

  Research output: Contribution to journal › Article › Academic › peer-review
  120 Citations (Scopus)
• 2017

  Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer

  Kandimalla, R., Linnekamp, J. F., van Hooff, S., Castells, A., Llor, X., Andreu, M., Jover, R., Goel, A. & Medema, J. P., 2017, In: Oncogenesis. 6, 4, p. e308

  Research output: Contribution to journal › Article › Academic › peer-review
  26 Citations (Scopus)

• Neoadjuvant chemotherapy affects molecular classification of colorectal tumors

  Trumpi, K., Ubink, I., Trinh, A., Djafarihamedani, M., Jongen, J. M., Govaert, K. M., Elias, S. G., van Hooff, S. R., Medema, J. P., Lacle, M. M., Vermeulen, L., Borel Rinkes, I. H. M. & Kranenburg, O., 2017, In: Oncogenesis. 6, 7, p. e357

  Research output: Contribution to journal › Article › Academic › peer-review
• 2016

  A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype

  Fessler, E., Jansen, M., de Sousa E Melo, F., Zhao, L., Prasetyanti, P. R., Rodermond, H., Kandimalla, R., Linnekamp, J. F., Franitza, M., van Hooff, S. R., de Jong, J. H., Oppeneer, S. C., van Noesel, C. J. M., Dekker, E., Stassi, G., Wang, X., Medema, J. P. & Vermeulen, L., 2016, In: Oncogene. 35, 46, p. 6026-6037

  Research output: Contribution to journal › Article › Academic › peer-review
  46 Citations (Scopus)

• An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF

  Koot, Y. E. M., van Hooff, S. R., Boomsma, C. M., van Leenen, D., Groot Koerkamp, M. J. A., Goddijn, M., Eijkemans, M. J. C., Fauser, B. C. J. M., Holstege, F. C. P. & Macklon, N. S., 2016, In: Scientific reports. 6, p. 19411

  Research output: Contribution to journal › Article › Academic › peer-review
  134 Citations (Scopus)

• TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

  Fessler, E., Drost, J., van Hooff, S. R., Linnekamp, J. F., Wang, X., Jansen, M., de Sousa E Melo, F., Prasetyanti, P. R., IJspeert, J. E., Franitza, M., Nürnberg, P., van Noesel, C. J., Dekker, E., Vermeulen, L., Clevers, H. & Medema, J. P., 2016, In: EMBO molecular medicine. 8, 7, p. 745-760

  Research output: Contribution to journal › Article › Academic › peer-review
  112 Citations (Scopus)
• 2015

  ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs)

  Prasetyanti, P. R., Capone, E., Barcaroli, D., D'Agostino, D., Volpe, S., Benfante, A., van Hooff, S., Iacobelli, V., Rossi, C., Iacobelli, S., Medema, J. P., de Laurenzi, V. & Sala, G., 2015, In: Oncotarget. 6, 19, p. 16902-16911

  Research output: Contribution to journal › Article › Academic › peer-review
  32 Citations (Scopus)
• 2013

  PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells

  Steller, E. J. A., Raats, D. A., Koster, J., Rutten, B., Govaert, K. M., Emmink, B. L., Snoeren, N., van Hooff, S. R., Holstege, F. C. P., Maas, C., Borel Rinkes, I. H. M. & Kranenburg, O., 2013, In: Neoplasia (New York, N.Y.). 15, 2, p. 204-217

  Research output: Contribution to journal › Article › Academic › peer-review
  80 Citations (Scopus)
• 2009

  The construction of genome-based transcriptional units

  van Hooff, S. R., Koster, J., Hulsen, T., van Schaik, B. D. C., Roos, M., van Batenburg, M. F., Versteeg, R. & van Kampen, A. H. C., 2009, In: Omics. 13, 2, p. 105-114

  Research output: Contribution to journal › Article › Academic › peer-review
• 2008

  Organization and integration of biomedical knowledge with concept maps for key peroxisomal pathways

  Willemsen, A. M., Jansen, G. A., Komen, J. C., van Hooff, S., Waterham, H. R., Brites, P. M. T., Wanders, R. J. A. & van Kampen, A. H. C., 2008, In: Bioinformatics. 24, 16, p. i21-i27

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)