Projects per year
Personal profile
Research interests
My research concerns lymphoproliferative malignancies, especially indolent lymphoma (including CLL) and Hodgkin's lymphoma. I am head of the national indolent lymphoma working group (HOVON) and act as a principal investigator for international trials and projects in indolent lymphoma and Hodgkin's lymphoma. In addition, I participate in clinical trials of the HOVON Lunenburg phase I / II consortium, the European Hematology assoociation EHA lymphoma group; and I am a member of the executive committee of the EORTC lymphoma group. Related to these projects I perform translational research into the interactions of lymphoma cells with the immune system; the research focuses mainly on how the immune system can best be used in the treatment of these diseases and the identification of biomarkers for response to immunotherapy.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 3 Active
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Kater A.P.: development of, circumvention of and novel strategies for (development of) chemorefractory CLL
van Attekum, M., Brocco, F., van Bruggen, A., Hofland, T., Leeksma, A., de Weerdt, I., Kater, A. P., Slinger, E., Tonino, S. & Wensveen, F.
1/06/2012 → …
Project: Research
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Eldering E.: Apoptosis regulation in immuno-hematology
Eldering, E., Kater, A. P., Slinger, E., Tonino, S., Wensveen, F., van der Windt, G., Derks, I., Terpstra, S., van Attekum, M., Brocco, F., Delgado, R., Hofland, T. & Leeksma, A.
1/01/2007 → …
Project: Research
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van Oers M.H.J.: Pathogenesis and Immunotherapy of B cell malignancies
Gerritsen, M., Gillissen, M., Kroeze, A., Schimmel, M., Sins, J. W. R., van Tuijn, C., Biemond, B. J., Kater, A. P., Kersten, M. J., Zeerleder, S., Hazenberg, M., Slinger, E. & Tonino, S.
1/01/2006 → …
Project: Research
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Functional Differences between EBV- and CMV-Specific CD8+ T cells Demonstrate Heterogeneity of T cell Dysfunction in CLL
Hofland, T., de Weerdt, I., Endstra, S., Jongejan, A., Platenkamp, L., Remmerswaal, E. B. M., Moerland, P. D., ten Berge, I. J. M., Levin, M-D., Kater, A. P. & Tonino, S. H., 2020, In: HemaSphere. 4, 2Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus) -
Human CXCR5+PD-1+ CD8 T cells in healthy individuals and patients with hematologic malignancies
Hofland, T., Martens, A. W. J., van Bruggen, J. A. C., de Boer, R., Schetters, S., Remmerswaal, E. B. M., Bemelman, F. J., Levin, M-D., Bins, A. D., Eldering, E., Kater, A. P. & Tonino, S. H., Mar 2021, In: European journal of immunology. 51, 3, p. 703-713 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access8 Citations (Scopus) -
Natural Killer Cell Hypo-responsiveness in Chronic Lymphocytic Leukemia can be Circumvented in Vitro by Adequate Activating Signaling
Hofland, T., Endstra, S., Gomes, C. K. P., de Boer, R., de Weerdt, I., Bobkov, V., Riedl, J. A., Heukers, R., Smit, M. J., Eldering, E., Levin, M-D., Kater, A. P. & Tonino, S. H., 1 Dec 2019, In: HemaSphere. 3, 6, p. e308 e308.Research output: Contribution to journal › Article › Academic › peer-review
Open Access15 Citations (Scopus) -
Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment
de Weerdt, I., Hofland, T., de Boer, R., Dobber, J. A., Dubois, J., van Nieuwenhuize, D., Mobasher, M., de Boer, F., Hoogendoorn, M., Velders, G. A., van der Klift, M., Remmerswaal, E. B. M., Bemelman, F. J., Niemann, C. U., Kersting, S., Levin, M-D., Eldering, E., Tonino, S. H. & Kater, A. P., 10 Sept 2019, In: Blood. 3, 17, p. 2642-2652 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access64 Citations (Scopus)