Research output per year
Research output per year
Personal profile
Research interests
My lab studies human genome aiming to dissect molecular mechanisms of susceptibility to infections and translate these findings into novel therapies. We have two programmes that focus on (1) primary immunodeficiencies and (2) mechanisms of host-pathogen interaction in tuberculosis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
Cuchet-Lourenço, D., Eletto, D., Wu, C., Plagnol, V., Papapietro, O., Curtis, J., Ceron-Gutierrez, L., Bacon, C. M., Hackett, S., Alsaleem, B., Maes, M., Gaspar, M., Alisaac, A., Goss, E., AlIdrissi, E., Siegmund, D., Wajant, H., Kumararatne, D., AlZahrani, M. S., Arkwright, P. D., & 3 others, 24 Aug 2018, In: Science. 361, 6404, p. 810-813 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access137 Citations (Scopus) -
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage
Angulo, I., Vadas, O., Garçon, F., Banham-Hall, E., Plagnol, V., Leahy, T. R., Baxendale, H., Coulter, T., Curtis, J., Wu, C., Blake-Palmer, K., Perisic, O., Smyth, D., Maes, M., Fiddler, C., Juss, J., Cilliers, D., Markelj, G., Chandra, A., Farmer, G., & 24 others, 15 Nov 2013, In: Science. 342, 6160, p. 866-71 6 p.Research output: Contribution to journal › Article › Academic › peer-review
432 Citations (Scopus) -
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration
Curtis, J., Luo, Y., Zenner, H. L., Cuchet-Lourenço, D., Wu, C., Lo, K., Maes, M., Alisaac, A., Stebbings, E., Liu, J. Z., Kopanitsa, L., Ignatyeva, O., Balabanova, Y., Nikolayevskyy, V., Baessmann, I., Thye, T., Meyer, C. G., Nürnberg, P., Horstmann, R. D., Drobniewski, F., & 3 others, May 2015, In: Nature Genetics. 47, 5, p. 523-527 5 p.Research output: Contribution to journal › Article › Academic › peer-review
111 Citations (Scopus) -
Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection
Eletto, D., Burns, S. O., Angulo, I., Plagnol, V., Gilmour, K. C., Henriquez, F., Curtis, J., Gaspar, M., Nowak, K., Daza-Cajigal, V., Kumararatne, D., Doffinger, R., Thrasher, A. J. & Nejentsev, S., 23 Dec 2016, In: Nature communications. 7, p. 13992Research output: Contribution to journal › Article › Academic › peer-review
76 Citations (Scopus) -
Immunodeficiency and disseminated mycobacterial infection associated with homozygous nonsense mutation of IKKβ
Burns, S. O., Plagnol, V., Gutierrez, B. M., Al Zahrani, D., Curtis, J., Gaspar, M., Hassan, A., Jones, A. M., Malone, M., Rampling, D., McLatchie, A., Doffinger, R., Gilmour, K. C., Henriquez, F., Thrasher, A. J., Gaspar, H. B. & Nejentsev, S., Jul 2014, In: Journal of allergy and clinical immunology. 134, 1, p. 215-8 4 p.Research output: Contribution to journal › Article › Academic › peer-review
32 Citations (Scopus)