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Van der Sluis’ research focusses on the question how human genetic research, heritability estimates, and genetic association signals are affected by choices concerning the operationalization (i.e., conceptualization, measurement and modelling) of the phenotypes involved. Topics that feature prominently in her research are: uni- versus multidimensionality, resolution of phenotypic instruments, the use of sum-scores versus item/symptom-level scores, genetic heterogeneity of complex phenotypes, and the genetic similarity and distinctness of phenotypically distinguished traits. Her work integrates psychological and psychometric topics with genetic and neuroscience research. The focus of van der Sluis’ research is on psychological and psychiatric traits. Van der Sluis is a VENI and VIDI laureate, and her current research is funded through co-application on a Top grant and a Gravitation grant.