Projects per year
Our principal scientific interest is in cells of the innate immune system and their contribution to the pathogenesis and treatment of disease, specifically related to cancer and immunotherapy. In the past years our group has focused on the role of phagocytes, such as macrophages and neutrophilic granulocytes, during monoclonal antibody therapy in cancer. We have, amongst other things, been exploring the basic mechanisms by which innate immune cells destroy antibody-opsonized cancer cells, which has most recently led us to identify the cytotoxic effector mechanism employed by neutrophils in this context (Matlung et al. (2018) Cell Reports 23:3946). Furthermore, we have been trying to identify the relevant immune checkpoints that control antibody-dependent cellular cytotoxicity (ADCC) by innate immune cells. As such we have found that interactions between CD47 expressed on cancer cells and SIRPα expressed on phagocytes, including neutrophils and macrophages, plays a very important role in limiting ADCC exerted by these cells (Zhao et al. (2011) PNAS 108:18342; Barclay and van den Berg (2014) Annu Rev Immunol. 32:25; Matlung et al. (2017)Immunol Rev. 276:145) . We are currently, in collaboration with Synthon Biopharmaceuticals, developing antagonists of the CD47-SIRPα interaction that we aim to combine with a variety of available cancer antibody therapeutics.
Together with the pediatric immunologists prof. dr. Taco W. Kuijpers our joined research group has also been active in the diagnosis and identification of rare primary immunodeficiency (PID) syndromes As such we have identified a number of novel primary immunodeficiency syndromes in our laboratory, including e.g. Leukocyte adhesion deficiency syndrome type 3 (LAD3) (Kuijpers et al. (2009) Blood. 113:4740) and ARPC1B-deficiency (Kuijpers et al. (2017) J Allergy Clin Immunol. 140:273).
Finally, we have been exploring the interactions of innate immune cells and red blood cells and platelets in other blood cell disorders, specifically in the context of blood transfusion research. As such we have been investigating genetic risk determinants of alloimmunization of transfused Sickle cell disease patients (Meinderts et al (2017) Blood 130:2121).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
PhD, Microenvironments in Lymphoid Tissues
1 Sept 1988 → 31 Dec 1992
Award Date: 16 Dec 1992
Master, MSc-cum laude
1 Sept 1982 → 31 Aug 1988
Award Date: 31 Aug 1988
Head Department of Blood Cell Research, Sanquin Research
1 Jun 2009 → …
Head Phagocyte Laboratory, Sanquin Research
1 Feb 2007 → …
- QR180 Immunology
- immune checkpoint
- innate immune cells
- NK cells
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- hematological and solid cancer
- monoclonal antibody therapy
Collaborations and top research areas from the last five years
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- 1 Active
van den Berg, T., Achetib, N., Bruggeman, C., Meinderts, S., Nagelkerke, S., van Rees, D., Scheenstra, M., Treffers, L., Hiemstra, I., Pourfarzad, F., de Boer, M., Geissler, J., van Houdt, M., van Leeuwen, K., Schornagel, K., Tool, A. T. J. & Verkuijlen, P.
1/01/2008 → …
Kuijpers, T. W., Tool, A. T. J., van der Bijl, I., de Boer, M., van Houdt, M., de Cuyper, I. M., Roos, D., van Alphen, F., van Leeuwen, K., Cambridge, E. L., Arends, M. J., Dougan, G., Clare, S., Ramirez-Solis, R., Pals, S. T., Adams, D. J., Meijer, A. B. & van den Berg, T. K., Jul 2017, In: Journal of allergy and clinical immunology. 140, 1, p. 273-277.e10
Research output: Contribution to journal › Article › Academic › peer-review85 Citations (Scopus)
6 Citations (Scopus)
Szilagyi, K., Gazendam, R. P., van Hamme, J. L., Tool, A. T. J., van Houdt, M., Vos, W. A. J. W., Verkuijlen, P., Janssen, H., Belot, A., Juillard, L., Förster-Waldl, E., Boztug, K., Kraal, G., de Winther, M. P. J., Kuijpers, T. W., van den Berg, T. K. & Forster-Waldl, E., 2015, In: Journal of allergy and clinical immunology. 136, 5, p. 1404-7.e1-10
Research output: Contribution to journal › Comment/Letter to the editor › Academic7 Citations (Scopus)
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic targetBarclay, A. N. & Van den Berg, T. K., 2014, In: Annual review of immunology. 32, p. 25-50 26 p.
Research output: Contribution to journal › Review article › Academic › peer-review508 Citations (Scopus)
CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destructionZhao, X. W., van Beek, E. M., Schornagel, K., van der Maaden, H., van Houdt, M., Otten, M. A., Finetti, P., van Egmond, M., Matozaki, T., Kraal, G., Birnbaum, D., van Elsas, A., Kuijpers, T. W., Bertucci, F. & van den Berg, T. K., 2011, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108, 45, p. 18342-18347
Research output: Contribution to journal › Article › Academic › peer-review240 Citations (Scopus)