Research output per year
Research output per year
Personal profile
Research interests
Interested in the interplay between the immune system and viruses, with a focus on B cells and antibodies in relation to HIV-1, SARS-CoV-2 (COVID-19) and influenza.
- It's time for an HIV-1 vaccine - germline targeting as a strategy to induce broadly neutralizing antibodies
- Identifying potent neutralizing antibodies that can prevent severe COVID-19
- Mechanistic understanding of B cells, antibodies and usage of B cell receptors in viral infections
specialisation
B cells, HIV-1, COVID-19, antibodies, protein design, vaccine design
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Guided by glycoproteins: Insights from antibody responses enable viral vaccine design
Caniels, T. G., 2024, 329 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal
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Broad SARS-CoV-2 neutralization by monoclonal and bispecific antibodies derived from a Gamma-infected individual
Guerra, D., Beaumont, T., Radić, L., Kerster, G., van der Straten, K., Yuan, M., Torres, J. L., Lee, W-H., Liu, H., Poniman, M., Bontjer, I., Burger, J. A., Claireaux, M., Caniels, T. G., Snitselaar, J. L., Bijl, T. P. L., Kruijer, S., Ozorowski, G., Gideonse, D., Sliepen, K., & 6 others, 20 Oct 2023, In: iScience. 26, 10, 108009.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
Caniels, T. G., Medina-Ramírez, M., Zhang, J., Sarkar, A., Kumar, S., LaBranche, A., Derking, R., Allen, J. D., Snitselaar, J. L., Capella-Pujol, J., Sánchez, I. D. M., Yasmeen, A., Diaz, M., Aldon, Y., Bijl, T. P. L., Venkatayogi, S., Martin Beem, J. S., Newman, A., Jiang, C., Lee, W-H., & 18 others, 18 Apr 2023, In: Cell Reports Medicine. 4, 4, 101003.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus) -
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Amsterdam UMC Covid-19 Biobank & Hollmann, M. W., 1 Nov 2023, In: Life Science Alliance. 6, 11, e202302106.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated α2-8-Linked Sialic Acids
Tomris, I., Unione, L., Nguyen, L., Zaree, P., Bouwman, K. M., Liu, L., Li, Z., Fok, J. A., Ríos Carrasco, M., van der Woude, R., Kimpel, A. L. M., Linthorst, M. W., Kilavuzoglu, S. E., Verpalen, E. C. J. M., Caniels, T. G., Sanders, R. W., Heesters, B. A., Pieters, R. J., Jiménez-Barbero, J., Klassen, J. S., & 2 others, 19 May 2023, In: ACS Chemical Biology. 18, 5, p. 1180-1191 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus)
Datasets
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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-04
Wu, N. C. (Contributor), Yuan, M. (Contributor), Liu, H. (Contributor), Lee, C. D. (Contributor), Zhu, X. (Contributor), Bangaru, S. (Contributor), Torres, J. L. (Contributor), Caniels, T. (Contributor), Brouwer, P. J. M. (Contributor), van Gils, M. (Contributor), Sanders, R. (Contributor), Ward, A. B. (Contributor) & Wilson, I. A. (Contributor), Protein Data Bank (PDB), 26 Aug 2020
DOI: 10.2210/pdb7JMO, https://www.wwpdb.org/pdb?id=pdb_00007jmo
Dataset
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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-39
Wu, N. C. (Contributor), Yuan, M. (Contributor), Liu, H. (Contributor), Lee, C. D. (Contributor), Zhu, X. (Contributor), Bangaru, S. (Contributor), Torres, J. L. (Contributor), Caniels, T. (Contributor), Brouwer, P. J. M. (Contributor), van Gils, M. (Contributor), Sanders, R. (Contributor), Ward, A. B. (Contributor) & Wilson, I. A. (Contributor), Protein Data Bank (PDB), 26 Aug 2020
DOI: 10.2210/pdb7JMP, https://www.wwpdb.org/pdb?id=pdb_00007jmp
Dataset
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Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs
Caniels, T. (Contributor), Medina Ramirez, M. (Contributor), Zhang, J. (Contributor), Sarkar, A. (Contributor), Kumar, S. (Contributor), LaBranche, A. (Contributor), Derking, R. (Contributor), Allen, J. D. (Contributor), Snitselaar, J. L. (Contributor), Capella-Pujol, J. (Contributor), Sánchez, I. D. M. (Contributor), Yasmeen, A. (Contributor), Diaz, M. (Contributor), Aldon, Y. (Contributor), Bijl, T. P. L. (Contributor), Venkatayogi, S. (Contributor), Martin Beem, J. S. (Contributor), Newman, A. (Contributor), Jiang, C. (Contributor), Lee, W. (Contributor), Pater, M. (Contributor), Burger, J. (Contributor), van Breemen, M. (Contributor), de Taeye, S. (Contributor), Rantalainen, K. (Contributor), LaBranche, C. (Contributor), Saunders, K. O. (Contributor), Montefiori, D. (Contributor), Ozorowski, G. (Contributor), Ward, A. B. (Contributor), Crispin, M. (Contributor), Moore, J. P. (Contributor), Klasse, P. J. (Contributor), Haynes, B. F. (Contributor), Wilson, I. A. (Contributor), Wiehe, K. (Contributor), Verkoczy, L. (Contributor) & Sanders, R. (Contributor), Protein Data Bank (PDB), 21 Jun 2023
DOI: 10.2210/pdb8E1P, https://www.wwpdb.org/pdb?id=pdb_00008e1p
Dataset