Projects per year
Personal profile
Research interests
Our research focuses on two research lines:
1. the impact of early life nutrition on gut maturation and later life gut health. Human intestine grows and matures rapidly between birth and 1 year of age. Early life nutrition is known to impact intestinal maturation and as such directly influence gut functioning during early life. Furthermore, adverse early life environment such as early life stress, antibiotic exposure, poor nutrition not only directly impact gut functioning, but also can lead to long term gut health impairments. In the current projects the impact of the early life nutrition on gut maturation, intestinal permeability is studied in human neonatal mouse models and human neonatal organoid cell cultures. By this approach we aim to 1) obtain mechanistic insight into the impact of early life nutrition on gut maturation/permeability and gut health during later life and 2) identify biomarkers for healthy gut maturation and gut health in general.
2. understanding the mechanisms of gut regeneration and how these are recapitulated during development of colorectal cancer. Making use of various epithelial damage models, transgenic mice and organoid cultures, current research focuses on Arginine biosynthesis pathway deregulation in cancer and epithelial regeneration.
specialisation
Intestinal epithelial homeostasis and disease, organoids, gut development, nutrition
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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van den Brink G.R.: Intestinal mucosal homeostasis and it's deregulation in inflammatory bowel disease and during oncogenesis
van den Brink, G., Hakvoort, T., Dijkstra - Muncan, V., Baan, B., Tjabringa, S., Westera, L., Wildenberg, M., Meisner, S., Vermeulen, J., Vogels, E., de Bruyn, J., van der Heijden, M., Houttuijn Bloemendaal, F., Levin, A., van Lidth de Jeude, J., Martins Garcia, T., van der Meer, J., Meijer, B., Navis, M., Prins, M., Smit, W., Spaan, C., Stevens, T., Westendorp, F., Karpus, O. & Verhaar, A.
1/10/2010 → …
Project: Research
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A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine
Roodsant, T., Navis, M., Aknouch, I., Renes, I. B., van Elburg, R. M., Pajkrt, D., Wolthers, K. C., Schultsz, C., van der Ark, K. C. H., Sridhar, A. & Muncan, V., 9 Jun 2020, In: Frontiers in cellular and infection microbiology. 10, 272.Research output: Contribution to journal › Article › Academic › peer-review
Open Access60 Citations (Scopus) -
A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration
Montenegro-Miranda, P. S., van der Meer, J. H. M., Jones, C., Meisner, S., Vermeulen, J. L. M., Koster, J., Wildenberg, M. E., Heijmans, J., Boudreau, F., Ribeiro, A., van den Brink, G. R. & Muncan, V., 1 Jan 2020, In: Cellular and Molecular Gastroenterology and Hepatology. 10, 2, p. 209-223 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access18 Citations (Scopus) -
ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair
Meijer, B. J., Giugliano, F. P., Baan, B., van der Meer, J. H. M., Meisner, S., van Roest, M., Koelink, P. J., de Boer, R. J., Jones, N., Breitwieser, W., van der Wel, N. N., Wildenberg, M. E., van den Brink, G. R., Heijmans, J. & Muncan, V., 1 Jan 2020, In: Cellular and Molecular Gastroenterology and Hepatology. 10, 1, p. 23-42 20 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access9 Citations (Scopus) -
Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity
Smit, W. L., Spaan, C. N., de Boer, R. J., Ramesh, P., Garcia, T. N. M., Meijer, B. J., Vermeulen, J. L. M., Lezzerini, M., MacInnes, A. W., Koster, J., Medema, J. P., van den Brink, G. R., Muncan, V. & Heijmans, J., 13 Oct 2020, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117, 41, p. 25560-25570 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access42 Citations (Scopus)
Datasets
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Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade
Cloherty, A. (Creator), Rader, A. (Creator), Patel, K. S. (Creator), Pérez-Vargas, J. (Creator), Thompson, C. A. H. (Creator), Ennis, S. (Creator), Niikura, M. (Creator), Wildenberg, M. (Creator), Dijkstra - Muncan, V. (Creator), Schreurs, R. (Creator), Jean, F. (Creator) & Ribeiro, C. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.22323729, https://tandf.figshare.com/articles/dataset/Berbamine_suppresses_intestinal_SARS-CoV-2_infection_via_a_BNIP3-dependent_autophagy_blockade/22323729
Dataset
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Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade
Cloherty, A. (Creator), Rader, A. (Creator), Patel, K. S. (Creator), Pérez-Vargas, J. (Creator), Thompson, C. A. H. (Creator), Ennis, S. (Creator), Niikura, M. (Creator), Wildenberg, M. (Creator), Dijkstra - Muncan, V. (Creator), Schreurs, R. (Creator), Jean, F. (Creator) & Ribeiro, C. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.22323729.v2, https://tandf.figshare.com/articles/dataset/Berbamine_suppresses_intestinal_SARS-CoV-2_infection_via_a_BNIP3-dependent_autophagy_blockade/22323729/2
Dataset