Projects per year
Personal profile
Research interests
- Developmental biology
- Heart development
- Transcriptional regulation
- Epigenetics
- Congenital heart defects
- Conduction system
- Sinoatrial node
- Arrhythmias
- Transgenic mice
- Lineage analysis
specialisation
developmental biology, molecular biology, heart development
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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Christoffels V.M.: Transcriptional mechanism controlling of heart pacemaker and conduction system formation
Christoffels, V., Barnett, P., Postma, A., Jensen, B., de Gier - de Vries, C., Wakker, V., van den Boogaard, M., van Duijvenboden, K., van Eif, V., Gunthel, M., Hooijkaas, I., Man, J., Mattiotti, A., Mohan, R., van Ouwerkerk, A., Prakash, S., Scholman, K., Schreuders, C. & van Weerd, H.
1/01/2007 → …
Project: Research
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EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures
van Duijvenboden, K., de Boer, B. A., Capon, N., Ruijter, J. M. & Christoffels, V. M., 2016, In: Nucleic Acids Research. 44, 5, p. e42Research output: Contribution to journal › Article › Academic › peer-review
31 Citations (Scopus) -
GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development
Stefanovic, S., Barnett, P., van Duijvenboden, K., Weber, D., Gessler, M. & Christoffels, V. M., 2014, In: Nature communications. 5, p. 3680Research output: Contribution to journal › Article › Academic › peer-review
74 Citations (Scopus) -
A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system
van Weerd, J. H., Badi, I., van den Boogaard, M., Stefanovic, S., van de Werken, H. J. G., Gomez-Velazquez, M., Badia-Careaga, C., Manzanares, M., de Laat, W., Barnett, P. & Christoffels, V. M., 2014, In: Circulation Research. 115, 4, p. 432-441Research output: Contribution to journal › Article › Academic › peer-review
38 Citations (Scopus) -
Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice
Aanhaanen, W. T. J., Boukens, B. J. D., Sizarov, A., Wakker, V., de Gier- de Vries, C., van Ginneken, A. C., Moorman, A. F. M., Coronel, R. & Christoffels, V. M., 2011, In: The journal of clinical investigation. 121, 2, p. 534-544Research output: Contribution to journal › Article › Academic › peer-review
Open Access80 Citations (Scopus) -
Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer
van den Boogaard, M., Wong, L. Y. E., Tessadori, F., Bakker, M. L., Dreizehnter, L. K., Wakker, V., Bezzina, C. R., 't Hoen, P. A. C., Bakkers, J., Barnett, P. & Christoffels, V. M., 2012, In: Journal of clinical investigation. 122, 7, p. 2519-2530Research output: Contribution to journal › Article › Academic › peer-review
154 Citations (Scopus)
Datasets
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sj-xlsx-2-tej-10.1177_20417314221127908 – Supplemental material for Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
Li, J. (Creator), Wiesinger, A. (Creator), Fokkert, L. (Creator), Boukens, B. (Creator), Verkerk, A. (Creator), Christoffels, V. (Creator), Boink, G. (Creator) & Devalla, H. (Creator), SAGE Journals, 2022
DOI: 10.25384/sage.21360651.v1, https://sage.figshare.com/articles/dataset/sj-xlsx-2-tej-10_1177_20417314221127908_Supplemental_material_for_Molecular_and_electrophysiological_evaluation_of_human_cardiomyocyte_subtypes_to_facilitate_generation_of_composite_cardiac_models/21360651/1
Dataset
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sj-xlsx-2-tej-10.1177_20417314221127908 – Supplemental material for Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
Li, J. (Creator), Wiesinger, A. (Creator), Fokkert, L. (Creator), Boukens, B. (Creator), Verkerk, A. (Creator), Christoffels, V. (Creator), Boink, G. (Creator) & Devalla, H. (Creator), SAGE Journals, 2022
DOI: 10.25384/sage.21360651, https://sage.figshare.com/articles/dataset/sj-xlsx-2-tej-10_1177_20417314221127908_Supplemental_material_for_Molecular_and_electrophysiological_evaluation_of_human_cardiomyocyte_subtypes_to_facilitate_generation_of_composite_cardiac_models/21360651
Dataset
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sj-xlsx-3-tej-10.1177_20417314221127908 – Supplemental material for Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
Li, J. (Creator), Wiesinger, A. (Creator), Fokkert, L. (Creator), Boukens, B. (Creator), Verkerk, A. (Creator), Christoffels, V. (Creator), Boink, G. (Creator) & Devalla, H. (Creator), SAGE Journals, 2022
DOI: 10.25384/sage.21360654.v1, https://sage.figshare.com/articles/dataset/sj-xlsx-3-tej-10_1177_20417314221127908_Supplemental_material_for_Molecular_and_electrophysiological_evaluation_of_human_cardiomyocyte_subtypes_to_facilitate_generation_of_composite_cardiac_models/21360654/1
Dataset
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Additional file 2 of Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung
Lüdtke, T. H. (Creator), Wojahn, I. (Creator), Kleppa, M. (Contributor), Schierstaedt, J. (Creator), Christoffels, V. (Creator), Künzler, P. (Creator) & Kispert, A. (Creator), Figshare, 2021
DOI: 10.6084/m9.figshare.14235009.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Combined_genomic_and_proteomic_approaches_reveal_DNA_binding_sites_and_interaction_partners_of_TBX2_in_the_developing_lung/14235009/1
Dataset
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sj-xlsx-4-tej-10.1177_20417314221127908 – Supplemental material for Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
Li, J. (Creator), Wiesinger, A. (Creator), Fokkert, L. (Creator), Boukens, B. (Creator), Verkerk, A. (Creator), Christoffels, V. (Creator), Boink, G. (Creator) & Devalla, H. (Creator), SAGE Journals, 2022
DOI: 10.25384/sage.21360657, https://sage.figshare.com/articles/dataset/sj-xlsx-4-tej-10_1177_20417314221127908_Supplemental_material_for_Molecular_and_electrophysiological_evaluation_of_human_cardiomyocyte_subtypes_to_facilitate_generation_of_composite_cardiac_models/21360657
Dataset