Walbert J. Bakker

PhD

20032022

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Personal profile

Research interests

Keratinocyte cancer is the most frequent cancer in the Netherlands and worldwide, and its incidence is rapidly increasing. One of the main research lines in the Laboratory of experimental Dermatology (LED) studies the relation between the immune system and skin cancer (both melanoma and keratinocyte cancer (non-melanoma skin cancer (BCC, SCC). Due to its high mutational load, skin cancer is a immunogenic cancer, which (in part of the patients) can be effectively treated with immunotherapy. Understanding how the immune system interacts with skin cancer is crucial for improving current cancer immunotherapies. Currently we focus on how the tumor microenvironment affects tumor immunity (for example, if and how hypoxia controls PD-L1 expression in melanoma).

Specialisation

Skin Cancer / Gene expression / Cancer Biology / Hypoxia / Immunology

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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