dr. Wiep Scheper

DR., (Principal Investigator)

    1992 …2024

    Research activity per year

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    Personal profile

    Research interests

    The neurodegeneration group studies the role of endoplasmic reticulum stress and proteostasis in neurodegenerative disorders, predominantly Alzheimer’s disease (AD). When a patient is diagnosed with AD, the neurodegenerative process is at an irreversibly advanced stage. For early diagnosis as well as for development of effective treatment or prevention it is pivotal to study early events. Our research is therefore focusing on early factors that drive the pathogenesis in sporadic AD, ultimately to identify a reversible phase in the disease process. Our previous work shows activation of the unfolded protein response (UPR) in neurons of AD patients and other tauopaties, very early in disease pathology. We aim to further determine the role of the ER stress response in the pathogenesis of AD with the ultimate goal to characterize early events in the disease process that may lead to the identification of new drug targets to prevent or delay AD pathogenesis. 


    Molecular cell biology of neurodegenerative diseases

    Ancillary activities

    No ancillary activities

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    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

    Education/Academic qualification

    PhD, Utrecht University


    • Q Science
    • Molecular and Cellular Biology, Translational Neuroscience
    • R Medicine
    • Neurodegenerative disease, Translational Neuroscience, Alzheimer's disease

    Collaborations and top research areas from the last five years

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